advertisement
Reply
 
Thread Tools Display Modes
Old 09-01-2018, 08:37 PM #31
janieg's Avatar
janieg janieg is offline
Member
 
Join Date: Jan 2014
Location: Maryland
Posts: 792
10 yr Member
janieg janieg is offline
Member
janieg's Avatar
 
Join Date: Jan 2014
Location: Maryland
Posts: 792
10 yr Member
Default

The CBD oil has an interesting side effect on me...nightmares. I never have them, and one both nights I tried it.

After some Googling, it appears others have had this issue too. I guess I'll try it during the daytime.
janieg is offline   Reply With QuoteReply With Quote

advertisement
Old 09-02-2018, 12:35 PM #32
DavidHC DavidHC is offline
Member
 
Join Date: Nov 2015
Posts: 732
8 yr Member
DavidHC DavidHC is offline
Member
 
Join Date: Nov 2015
Posts: 732
8 yr Member
Default

Interesting and unfortunate. I'm sorry to hear that. CBD had a number of contradictory effects and side effects, causing nightmares in some and ridding others of them as well as of night terrors. Yes, maybe a morning dose will avoid this side effect.
DavidHC is offline   Reply With QuoteReply With Quote
Old 09-21-2018, 06:27 AM #33
janieg's Avatar
janieg janieg is offline
Member
 
Join Date: Jan 2014
Location: Maryland
Posts: 792
10 yr Member
janieg janieg is offline
Member
janieg's Avatar
 
Join Date: Jan 2014
Location: Maryland
Posts: 792
10 yr Member
Default

I've tried it three more times at night since that's when I really need it, and no nightmares. I also think it helped my symptoms. Win-win.
janieg is offline   Reply With QuoteReply With Quote
Old 09-22-2018, 09:57 AM #34
DavidHC DavidHC is offline
Member
 
Join Date: Nov 2015
Posts: 732
8 yr Member
DavidHC DavidHC is offline
Member
 
Join Date: Nov 2015
Posts: 732
8 yr Member
Default

That's wonderful to hear! I'm always happy to hear that CBD is helping someone, especially a fellow neuropathy sufferer.
DavidHC is offline   Reply With QuoteReply With Quote
Old 09-23-2018, 12:25 AM #35
Streetlegal Streetlegal is offline
Junior Member
 
Join Date: Sep 2018
Posts: 68
5 yr Member
Streetlegal Streetlegal is offline
Junior Member
 
Join Date: Sep 2018
Posts: 68
5 yr Member
Default

Hello David,

I am something of a neophyte when it comes to cannabis, but I was passing a cannabis outlet in San Francisco today and got myself a packet of Plus Products CBD gummies (expensive it seems at $20 for 20 gummies).

They are as follows: 5 mg of CBD per gummy.

My question: does this seem like it might be a suitable product to trial? And how many mg per day might be considered "default" for someone with mild idiopathic PN?

PS I also purchased some THC gummies as an occasional recreational substitute for alcohol--is it a bad idea to mix the THC with the CBD gummies?

Much obliged to!!
Streetlegal is offline   Reply With QuoteReply With Quote
Old 09-23-2018, 01:06 PM #36
DavidHC DavidHC is offline
Member
 
Join Date: Nov 2015
Posts: 732
8 yr Member
DavidHC DavidHC is offline
Member
 
Join Date: Nov 2015
Posts: 732
8 yr Member
Default

Hi there,

Yes, that could work, and CBD and THC are meant to be taken together, so you would be just fine. In fact, if you take the THC and then don't like the effect, you can minimize it by taking more CBD as the latter works against THC and reduces the psychotropic effect of the cannabinoid. Too much CBD and you just won't feel the THC at all. A 1:1 ratio will still be pretty psychoactive.

And yes, that is pricey, but standard unfortunately. There are cheap ways to go if you need higher doses of CBD for medicine, in particular by purchasing CBD isolate and making your own edibles, tincture and balm.

I'm not sure how suitable it will be for a quality trial. Ingestion unfortunately significantly reduces the bioavailability and delays the onset. So it's pretty wasteful and difficult to measure the dosage needed. The use of tincture or smoking/vaping is easier to control and the effect is immediately noticeable. It also significantly increases the bioavailability so there is much less waste. However, there is some limited evidence that the effect of ingestion lasts longer and is more systematic, whatever that means. I would try various methods and see what works best for you. Only you'll know what's best for you and only after you've tried various methods of consumption. Ingestion works well for many people.

Dosage is also something you'll have to figure out on your own. I guess if I were you, I'd try one gummy a day for a couple of days and see how that goes. Then increase slowly. And if you want to see what each cannabinoid does for you, don't take both at once, at least initially.
DavidHC is offline   Reply With QuoteReply With Quote
Old 09-26-2018, 12:43 AM #37
Streetlegal Streetlegal is offline
Junior Member
 
Join Date: Sep 2018
Posts: 68
5 yr Member
Streetlegal Streetlegal is offline
Junior Member
 
Join Date: Sep 2018
Posts: 68
5 yr Member
Default

Hi David,

So far so good, with the CBD (three days). My situation is compounded by the fact that, aside from PN, I have a number of other chronic auto-immune conditions, the worst being colitis. I am having a bad colitis flare (in fact, it never really stops, and I always test for inflammation in my body) right now.

But perhaps the CBD might help with the colitis . . . I certainly don't think it can make it any worse.

Anyway, to my point. In your original post you mused how CBD might function as a vasodilator. Interestingly, besides CBD I am presently doing my own self-trial of daily sildenafil (yes, Viagra!). I have persuaded my doctor to give me a very low daily dose (10-20mg) as there has been anecdotal and lab evidence that it can significantly mitigate diabetic neuropathy. Of course, the fly in the ointment is that diabetic and idiopathic represent different mechanisms--the vasolidator component might be what works for diabetics who lack the proper blood supply to nerves (poorly written, but you get my drift).

Two weeks in, I can say that my neuropathy symptoms (mainly constant fasciculations and fluid paresthesias) are improved from the weeks before--though this condition varies like hell anyway.

Fingers crossed that either of the self-meds--perhaps both--produce results.

Cheers

PS a question--you probably say this, but do you think that CBD merely mitigates symptoms or does it having any impact at all on the actual condition?
Streetlegal is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
Joe Duffer (09-26-2018)
Old 09-27-2018, 12:59 PM #38
DavidHC DavidHC is offline
Member
 
Join Date: Nov 2015
Posts: 732
8 yr Member
DavidHC DavidHC is offline
Member
 
Join Date: Nov 2015
Posts: 732
8 yr Member
Default

Hi there,

Glad to hear it. I know a number of people who use CBD (and a few THC) for Colitis and it really does help them. I'm sure you'll be able tell soon enough. But on a basic level CBD is known to reduce inflammation, so that alone will be immensely beneficial to you.

That's fascinating about sildenafil. I think I had heard this but I'm not sure. But it seems like that and the CBD are working well on that front. My fasciculations have improved since taking CBD too. When they get bad, I take some CBD and it's gone within minutes. I hope it keeps working for you.

This is a complicated question to answer, primarily because quality human trials have yet to be conducted. The limited scientific evidence and a more sizable amount of anecdotal evidence seems to show that in higher doses it can lead to actual improvement in certain conditions. I would look at the article I posted initially from Leaf Science and read some personal experiences from people. Most people take very low doses and so only experience symptom relief. But given its therapeutic value, including lowering inflammation and being neuro-regenerative and not just neuroprotective, CBD (and actually THC and other cannabinoids) seem to have a genuine ability to effect real healing. There are some studies underway, and I hope the changing legal landscape more quality studies will be conducted.
DavidHC is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
dogwalker (09-28-2018)
Old 09-29-2018, 04:10 AM #39
kiwi33's Avatar
kiwi33 kiwi33 is offline
Grand Magnate
 
Join Date: Jan 2015
Location: Sydney, Australia.
Posts: 3,093
8 yr Member
kiwi33 kiwi33 is offline
Grand Magnate
kiwi33's Avatar
 
Join Date: Jan 2015
Location: Sydney, Australia.
Posts: 3,093
8 yr Member
Default

Quote:
Originally Posted by Streetlegal View Post
But perhaps the CBD might help with the colitis . . . I certainly don't think it can make it any worse.
There is some evidence that CBD can help with colitis.

A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of U... - PubMed - NCBI
__________________
Knowledge is power.
kiwi33 is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
DavidHC (09-29-2018)
Old 10-15-2018, 04:08 PM #40
stillHoping stillHoping is offline
Member
 
Join Date: May 2015
Posts: 154
8 yr Member
stillHoping stillHoping is offline
Member
 
Join Date: May 2015
Posts: 154
8 yr Member
Default

Hi David
I'm glad that you found a treatment that works for you
and thanks for the info about the CBD!
stillHoping is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
DavidHC (10-16-2018)
Reply

Tags
cbd, doses, i’m, i’ve, it’s

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Cannabinoid Hyperemesis Burntmarshmallow Alcoholism, Addiction and Recovery 4 09-13-2021 09:24 AM
Cannabinoid Agonist Significantly Increases ALS Life Span, Study Says BobbyB ALS 1 01-26-2007 08:13 AM
Insulin secretion and psychotropic drugs firemonkey Schizophrenia 0 12-01-2006 06:07 PM
Synthetic cannabinoid Nabilone significantly reduces spasticity-related pain wannabe Multiple Sclerosis 2 10-04-2006 07:28 PM


All times are GMT -5. The time now is 09:24 PM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.