Hi David,

So far so good, with the CBD (three days). My situation is compounded by the fact that, aside from PN, I have a number of other chronic auto-immune conditions, the worst being colitis. I am having a bad colitis flare (in fact, it never really stops, and I always test for inflammation in my body) right now.

But perhaps the CBD might help with the colitis . . . I certainly don't think it can make it any worse.

Anyway, to my point. In your original post you mused how CBD might function as a vasodilator. Interestingly, besides CBD I am presently doing my own self-trial of daily sildenafil (yes, Viagra!). I have persuaded my doctor to give me a very low daily dose (10-20mg) as there has been anecdotal and lab evidence that it can significantly mitigate diabetic neuropathy. Of course, the fly in the ointment is that diabetic and idiopathic represent different mechanisms--the vasolidator component might be what works for diabetics who lack the proper blood supply to nerves (poorly written, but you get my drift).

Two weeks in, I can say that my neuropathy symptoms (mainly constant fasciculations and fluid paresthesias) are improved from the weeks before--though this condition varies like hell anyway.

Fingers crossed that either of the self-meds--perhaps both--produce results.

Cheers

PS a question--you probably say this, but do you think that CBD merely mitigates symptoms or does it having any impact at all on the actual condition?