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10-21-2018, 10:53 AM | #1 | ||
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Interesting and wonderful to hear. Now I'm curious: what have you done? It might be worth detailing some of it to help others on here, or perhaps you've already done that on another thread?
Also, on a side note, the salve from Fully Activated is excellent for more surface issues, including neuropathic itch and burning. It alleviates mine immediately. |
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10-23-2018, 09:44 AM | #2 | ||
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10-24-2018, 02:14 PM | #3 | ||
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I'm sorry you're suffering and conventional medicine hasn't been able to help so far. I'm in the same boat.
You raise a number of issues here. I'll try to address some of them and hope that helps. First off, you will need to experiment yourself, since no one else can tell you what is helping or harming you except you, to the extent that that's possible, to the extent that you feel it. Cannabis might be making things worse for you, but only you can tell, and after some experimentation with dosage, strains and methods of administration. Cannabis is very diverse and each strain has a variety of phytochemicals. Some strains are terrible for me, others work magic. Some make my symptoms worse because of the combination and/or ratios of cannabinoids and terpenes, others relieve them and give me great comfort. If you're using dry flower that's easy to know, but each oil or edible is also made from some specific flower with specific ratios and kinds of a variety of phytochemicals. You're using 1:20 THC to CBD, so you might need to change that ratio, or maybe try another oil from another plant with other terpenes than the one you're using. You might increase the THC, or you might even try CBD isolate since THC and other cannabinoids could be what is causing you problems. Regarding dosage, 5 mg is very low. In studies the doses administered are usually hundreds of mg for human adults. Sublingual is a good method of administration for bioavailability. Hopefully this answers some of your questions. |
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10-24-2018, 06:04 PM | #4 | ||
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10-25-2018, 01:34 PM | #5 | ||
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Thank you and I'm glad to hear it.
It's immensely difficult to live with this illness and all the many forms it takes. We need whatever we can get in the struggle. Vaping flower might be an option for you if you want to experiment more with different strains and such things. It might also be worth increasing you dose if you're willing. Studies show you need much higher doses than that for pain management and pretty much any benefits. But you will know best what you're willing to do. If you do vape, you won't need a vape pen, but a dry herb vaporizer, say like a Pax or even better an Arizer vaporizer like the Air or Solo. This will be easy to use for a newcomer. And it goes without saying that it's a reasonable alternative to opioids, a very reasonable one! |
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10-26-2018, 11:01 AM | #6 | ||
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Some information on a recent study of CBD and neuropathic pain:
Cannabis pain relief without the 'high' | EurekAlert! Science News The PubMed link: Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. - PubMed - NCBI |
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10-26-2018, 10:41 PM | #7 | ||
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Hi David!
I want to give you some early feedback regarding my first use of CBD. First, I am using the "Fully Activated" company's CBD "Full Spectrum" capsules. I am taking a total of 90 mg daily (I was told to take half my weight of 180 pounds for a total daily mg dosage). Here is an example on the website of the capsules I am taking: Full Spectrum Capsules – Activated Shipping After taking 90 mgs daily (60 mg at bedtime and 30 mg midday) for 72 hours (three days), I developed a faily severe headache centered in my forehead by the third day. I also did not notice any pain relief (and, if anything, my overall pain seemed to be worse in addition to the headache). Indeed, the headache was bad enough I skipped today's dosing completely. This was a disappointing start, and I would like to get what feedback you can offer (I will also call Nick on Monday). Many thanks! David |
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10-27-2018, 10:03 PM | #8 | ||
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Thank you for this thread, which has prompted me to experiment again with CBD.
I've tried a number of different CBD/Hemp oil products and have been mostly disappointed (as in no benefit seen despite hundreds of dollars spent). However, I'm trying again, with higher doses in mind. (GENETICS I suspect genetics may play a role in sensitivity to CBD; for example, the 23&me test has some cannabinoid receptors tested for polymorphisms; but I've never seen genetics mentioned in any discussions or studies of CBD use). DOSE As other posts mention, some suggest the dose of 5mg for every 10lb (or, 1/2 your weight in miligrams). CONCENTRATION However, dosing is not so simple, as different products have different "percentages" (of CBD, CBDa, other stuff...). For example, an Endoca oil looks appealing (organic, high 15%, etc.). (I can't post the link yet...) BUT, if I go for that 90mg daily dose, this $130 bottle will last me 16 days, costing about $8 per day (1500 mg / 90 mg/day = 16.67 days. $130 / 16.67 days = $7.79) Not COMPLAINING (I'd rather put this stuff in my mouth than Lyrica, etc.), but just pointing out an example of the costs involved here, and the complicating factor of concentration. Most of the CBD options out there are way over-priced. It's the Wild West with the cannabis industry, and greed and fraud are everywhere. It seems it may take a while to titrate up (at least for me--I guess I was trying with far too little before) and figure out a useful dose. (One more opinion: watch out for the miracle stories--"one drop and all my pain was GONE!"--they're likely B.S. and irrelevant to anyone else's experience.) |
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10-28-2018, 10:21 AM | #9 | ||
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Quote:
If you read my post just above yours, you can learn about my initial experience using the "Full-Spectrum" CBD oil offered by the company "Fully Activated". They seem to offer a good product, which "DAVIDHC" here on the forum agrees with (and he knows Nick, who owns the company and was a wealth of information when I called). Regarding dose, like you it was suggested using a dosage in milligrams that is one-half my body weight. As I weigh 180 pounds, I thus started with 90 milligrams of the CBD oil in capsule form daily. I started my test with CBD five days ago, and took a 60 mg capsule at bedtime and 30 mg capsule mid-day each day. Unfortunately, I did not notice any pain relief, but rather developed a pretty bad headache by the third day (dosing at 90 mg daily) that was uncomfortable enough to stop the CBD. I even seemed to have an enhancement of all of my body-wide pain, too! I then stopped the capsules two days ago, and within 24-hours (yesterday) my headache was much better. I am now waiting for feedback from "DAVIDHC" here on the forum, and will also call Nick at "Fully-Activated" on Monday for his feedback. David |
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10-28-2018, 12:53 PM | #10 | ||
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There's lots on here and unfortunately I don't have time to get into lots of details. But I'll make a few points and maybe they'll be helpful to you both.
For starters, I'm glad you're both experimenting. Cannabis is not a monolith and each strain is unique, this includes full spectrum products, each of which contains different ratios and kinds of cannabinoids and terpenes. If one doesn't work or doesn't give you the benefits you like, it doesn't mean they all won't work. Price is really an issue, and so too is greed. There are companies that have compassionate pricing and then there is isolate. CBD isolate can get pretty cheap, as low as $10-15 per gram if you purchase larger quantities. I use isolate for this reason. Dosage is complicated and everyone is different. There are some studies and everyone has an opinion. Ultimately you have to find what works for you. The dosage recommendations in the few studies out there are extremely high I find, partly because they focus on oral administration and that has reduced bioavailability, but I also can't speak to the quality of the CBD they're using. Scientific research into CBD is highly limited at this point but is increasing. David, to your particular experience, it's not abnormal to experience headaches. I would do two things, decrease my dose and see how that goes, maybe even starting at a much lower dose and slowly working up. And second, I would try CBD isolate. You can try other full spectrum products too, but try isolate for sure and see how that goes. I know quite a few people who don't do well with full spectrum but thrive on isolate. You see, what you're taking has many different phytochemicals in it so there's no way to tell what the problem is. If you want to know whether CBD itself works for you, you will need to try isolate. Like I have said, I can't tolerate full spectrum myself when it comes to hemp and even most strains of MJ, but I do great when it comes to CBD isolate. |
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