Hi Liqidz--are you sure about that? If you have any links to abstracts of articles I would be very interested.

Cheers
Paul

Here are the complete studies that they have ever done i think compiled into this pdf.
Just click on ''download PDF'' and you'll be able to see it.
If you do a key word search on oral within the pdf,you'll be able to see that it is effective

US2�19��4654�A1 - Treatments for diabetic symmetrical polyneuropathy
- Google Patents




Also i spoke to someone on reddit which stated that they were working on a topical drug for neuropathy which is going really well,didn't state which company or cream ,but pretty obvious :P

We are two scientists and we are walking into a bar AMA! : IAmA

Two very encouraging quotes from "We are two scientists and we are walking into a bar AMA! : IAmA" link above

"I'm currently working on a topical drug specifically targeting small fiber neuropathy. We are in phase II clinical trials and it's going really, really well. It's a topical drug that should really help with basically no side effects"

"We think our cure works regardless of the etiology behind the neuropathy, but there are some exceptions to this rule"

That's an interesting find!

Does anyone know of a legal source for purchasing medical grade pirenzepine to be compounded into a topical medication? So far, I have discovered it is not available in the u.s. and I think Mexico. You can get 25 mg tablets from Japan but not sure of the quality or purity. I do not want to break a law, just that at age 73, and considering reports of safety that I have nothing to lose. thanks and best to all

are there any avenues for "compassionate use" available during trials as I understand that this therapy will not apply to those whose nerves are destroyed meaning you must have some residual nerves available. for long haulers, or those who are becoming long haulers post diagnosis, by the time pirenzepine is available, it will be too late.

For anyone who might want them, I have a whole load of Oxytrol boxes, unopened if anyone in the San Francisco area wants to take them off my hands for free. I stopped the treatment over a year ago and went back on nortripyline.

Oxytrol contains pirenzipine.

Hi I am new to this forum and thread.
I have had peripheral neuropathy for a few years now and it has been getting steadily worst. I had it in my feet and I resisted medication as long as I could but it was getting dangerous driving so my doctor put me on lyrica.. I needed 150mg twice a day to control my symptoms but side effects were not good so I compromised with 125 mg twice a day with some PN symptoms but tolerable. However I then had a COVID vaccine first jab and my PN went crazy…and the PN started in my hands….nothing would stop the pain and it went on like this for 4 weeks…I thought this would be the end. Constantly reading everything on the net I came across the studies of pirenzepine and ED medication Cialis and people posted on reddit experience with both.
I am so over this PN affecting my life every moment of every day it can drive you crazy and if it does t then drugs like lyrica will.
I ordered pirenzepine online via what seemed a dodgy online site via a London bank account and the drugs shipped from Japan. I also ordered 50 x 20mg cialis from an online chemist.
The scientist in me wanted to just try each individually to see what worked but the impatient patient just wanted to fix this ASAP.
I started taking the pirenzepine orally 50mg twice a day . I also started taking cialis 20mg every second day.
After one week my PN symptoms started reducing and I cut my lyrica down to 100 mg twice a day… don’t get me wrong I still get pins and needles but they felt different … no burning or overwhelming sensations anymore.. I stopped the cialis for a day or two as I thought it may have been affecting my hearing but no it was al good.
I am now at the end of week two and I am now on 75 mg of lyrica twice a day. Still taking pirenzepine 50mg twice a day. I have jumped online and bought 4 more boxes.
My PN is not flaring anymore and seems to be slowly getting better . I can feel the accelerator pedal under my foot now so driving is much more comfortable. I figure it will take several months for my nerves to recover. I still have lots of pins and needles but no real pain anymore.
I will keep my progress posted for anyone interested. Sympathies to anyone and everyone suffering with neuropathic pain. I don’t recommend doing what i am doing just letting everyone know my experience.

Hi, I would be interested in this information also.

I have idiopathic small fiber neuropathy and am trying Oxytrol patches. I'm on day 5 and I've been feeling better lately, but my pain level can vary quite a bit. I will report back in a few weeks. Fortunately no major side effects so far.

Anyone think their Dr. can give them an Rx for the gel? I feel like that would be more targeted and stronger vs the patch. I'm hoping to persuade a neurologist to write me an Rx for the gel.