Under "Recent News" the Winsantor website announces an "Ask Me Anything" May 6.

I'm not a member of Reddit, but the AMA format is one in which experts answer questions from interested parties.

This could be an interesting opportunity.

Home - WinSanTor

(Look under "Recent News")

Link to Winsantor Twitter:

Twitter

Thanks, Streelegal. I just got an email saying that their AMA will be happening at 8:30am PST/11:30am EST on Monday, May 6, 2019.

Their website is very interesting. Peripheral Neuropathy and Our Drug - WinSanTor

WinSanTor says the've discovered compounds that prevent and reverse PN. Their lead drug is WST-057. "WST-057 is therefore a proprietary topical reformulation of an existing (off-patent) oral drug repurposed to be more conducive to treating patients with peripheral neuropathy."

It appears this drug is based on Pirenzepine, although they also mention a couple of other agents. Pirenzepine is not available in the US, otherwise I'd go doctor-shopping to get it.

Has anyone on this board in Canada, Europe, Japan, or elsewhere used Pirenzepine for treatment of their neuropathy?

Hi Nilram

Oral pirenzepine would have to be taken at unsafe levels to have any effect, apparently. It is not sufficiently bioavailable in oral form to reach the nerve cells, unfortunately, or at least not at safe levels.

However, fingers crossed Winsantor should have a research study coming out this summer reporting on the use of a topical form of pirenzepine or another closely related antimascurinic such as oxybutynin.

Paul

Anyone know how the AMA works on Reddit? I've seen some but never participated.

I'm assuming one has to post questions "live" and can't upload them beforehand . . .

Peripheral Neuropathy drug - AMA on Monday, May 6, 8:3 am PST : neuropathy

Here is the link to the AMA, May 6 2019 on Reddit:

We’re WinSanTor, a patient owned pharmaceutical company with a drug that aims to reverse peripheral neuropathy AMA! : IAmA

Lots of reasons to be cautiously optimistic, IMHO. I quote from Stanley Kim, CEO:

When you say "reversal" do you mean alleviating symptoms or actually reversing damage and healing nerves? Can it also stop progression of further damage?

Stan: The studies in humans included biopsies as well as funtional tests. It showed signficant improvement of both. Again, this was by our scientists to understand whether our class of drugs would work. One of those drugs worked very well (tested on humans). We are taking what we believe to be the safest of those drugs (from the class of drugs tested on animals) forward.

I'll put in another pitch here for folks to fill in the patient survey on their web page:

Home - WinSanTor

There is so little research being done on PN by big pharma that I think it behooves us all to support the company in its efforts to find a treatment and to keep neuropathy in the news. The fact is, after some big trial fails, and with a focus on more profile health issues, big pharma is not at all interested in backing PN research; this is a company set-up by specialists on the back of government grants. Let's show them our support! At the very least, they offer a glimmer of hope.

Paul