Folks anyone with high uric acid and peripheral neuropathy?. I have high uric acid and prescribed 200mg allopurinol for that .. Currently the allopurinol is on hold to see if that is related to my PN.

I tested my Serum UA today and found it to be 7.8 mg/DL (should be 7.2 or below).


I found the link below which describes a possible link between Serum UA and PN

google "can high uric acid cause neuropathy?" and see the results as I cannot post links

The PubMed search "peripheral neuropathy uric acid" retrieves 106 papers. The main link seems to be with diabetic PN.

As far as I can see whether this is correlative or causative is unclear. See https://www.jns-journal.com/article/...18)30194-1/pdf.

Any such studies on uloric (febuxostat) and nerve pain? I was initially prescribed uloric for my gout but discontinued after 6 months partly because it caused some abdominal discomfort and partly because my insurance wont cover it. My doctor switched me over to allopurinol, which I had for a year before neuropathy symptoms surfaced. I am thinking of switching back to uloric .. Better pay from my own pocket than sufferer from this nasty neuropathy..

2 month update
 

Posting a 2 month update since my suspected PN symptoms started showing up : Symptoms seem to have lessened a bit , but not completely gone. I still get the odd pins and needles and tingling , burning sensations , mostly at night around bedtime , but it calms down after that and does not really affect sleep. My regimen, as you all know, is purely supplements based: R-ALA , Acetyl L- Carnitine , benfotoamine and a generic mens multivit. I also take levothyroxine for hypothyroidism and allopurinol for gout.

Is this normal progression for a PN ? a period of initial flareup followed by a reduction of symptoms? what path can we expect this to take in future? I have e neuro appt later this month. Not sure what to ask him . Should I ask for any bloodwork or any nerve conduction studies? Thanks a lot

Neuro visit update
 

Had my first neurologist visit yesterday. Did EMG which was normal.. Ordered bloodwork , which included B6, Copper, quantitavive immunoglobulins, and an MRI scan as well. But he was not convinced it was PN and advised a wait and watch approach. My impressions are most doctors/specialists are not really bothered unless the symptoms are serious/severe in nature. Also, not much feedback regarding supplements I am taking. Just " If they are helping, continue to take them".
That is where , forums like these are of immense help. Really frustrating when you are fighting something like PN and you don't know whom to approach.

Cause of Neuropathy is critical
 

The key to battling neuropathy is to find the cause of the neuropathy. If you are dealing with diabetic neuropathy, then you are in luck (sort of) as there are a number of things that you can do to fight it. Reducing blood glucose to normal levels, taking alpha lipoic acid, taking l-serine to help reduce the number of deoxysphingolipids in your blood stream and even losing weight can help with diabetes / pre-diabetes. There is also research in reversing diabetic neuropathy with selective M1R antagonists ( pirenzepine). By the way, if you are pre-diabetes, they have also found nerve damage with that as well. The system will not allow me to post links so if you are interested in the scientific research regarding diabetes and serine, pirenzepine, alpha lipoic acid just google it. You would als osee in google searches that prediabetes is linked to neuropathy.

I have my blood work results from my recent lab tests . Quantitative immunoglobulins, Vitamin B6, Vitamin E , protien electrophoresis and zinc were normal, copper was high ..

My previous blood tests including CBC, fasting glucose, B12 , thyroid etc were also normal.

Does anyone know the consequences of high serum copper? Does it have any relation to PN?

Copper toxicity can be neurologically problematic although a bit rare. Usually copper toxicity exhibits neurological issues like dystonia and tremor. These symptoms don't seem to be the symptoms that you are having.

Copper deficiency symptoms are more like the symptoms that you have but you have high copper levels not low.

Just out of curiousity, how high was your copper? Normally, our bodies dump extra copper pretty well so maybe the copper issues point to some other underlying issue that could be related to the neuropathy. Did your doctor have any opinions regarding your bloodwork or did you get an idiopathic diagnosis?

So far no diagnosis. Wating for an MRI in October. Copper was marginally high at 23.8 at umol/L (should be below 22).. My sugar (although "normal" as per the doctor) seems to be in the pre diabetic range (fasting 102 mg/dl and 160-170 mg/dl 2 hours post prandial) . That , alongwith my allopurinol medication for gout are my prime suspects at the moment

Here is what the report says about ALA,
"However, they have shown a moderate benefit in terms of pain reduction[132]. In a randomized double-blinded trial, ALA-treated patients reported a greater reduction in neuropathic pain when compared to placebo-treated subjects[122]. "