Atticus this is the program that has worked for me for 5-6 years, Inosine is being added to the mix.
Name
Dose Per
Rationale / Comments
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Vit B12
1,000 - 6,000 mcg day
Boosts nerve function. Is required for and dramatically speeds nerve healing. Compensates for possible deficiency. Use sublingual methylcobalamin if available, or 1,000 mcg of cyanocobalamin if not. Take IN ADDITION TO the B-complex. Up to 36,000 mcg/day injected are prescribed in Japan for PN.
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B-complex
B-50 1/day
Needed for energy, nerve function, nerve healing. A B-50 formulation is about twice as strong as a regular B-complex. Two B-50s or one B-100 is at the upper safety limit. Take with breakfast so it help your body utilize your food all day.
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Folate or folic acid
Up to 1200 mcg. 1/day
An important component in nerve function, shown to be deficient in many cases of neuropathy. Helps fight depression and bipolar disorder. Check the folate level in your B-50, and supplement with enough to bring your folate intake to 800 - 1200 mcg/day. Men with neuropathy need more than women. If it doesn’t help within about six weeks, the amount in your B-50 should be sufficient.
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Vit C
250 mg./day. The latest research is that this is all we can use. Not needed if you eat a good diet since almost all fruit and veggies have vitamin C. Antioxidant, heals nerves.
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Vit E mixed tocopherals.
400 iu /day
Antioxidant, heals nerves. More than 400 iu of cheap sythesized l-alpha-tecopheral can cause heart problems. Formulations with plenty of gamma-tocopherals and are heart and nerve healthy. Is a blood thinner. Ask your doctor if you take prescription blood thinners.
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Acetyl-L-Carnatine
500 mg. 2/day
Heals nerves, reduces pain, improves memory, elevates mood and increases energy. Works with Alpha lipoic acid. 3,000 mg./day heals nerves and reduces pain over a year's use in several studies. That would be very costly, but worthwhile if you can afford it.
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Alpha Lipoic Acid
800 mg. day
Antioxident. 800 mg./day is prescribed in Europe for PN. Help all tissue repair and nerve function. The only antioxidant that gets into neurons because it is both fat and water soluble. Works with the Acetyl-L-Carnatine
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SAMe
400 - 1200 mg 1/day on an empty stomach
Methyl donor. Potent antioxidant. Help vitamins and enzyme systems work. Fights depression, aids sleep, anti-arthritic. Helps liver detoxification. Ask your doctor if you have bipolar disorder because it can increase manic phase symptoms. Expensive, so start with 1200 mg/day, then taper to 400 or 800 mg. after two weeks.
------------------
Calcium/Magnesium
500 mg. Magnesium 2/day
Nerve and muscle function, bone strength. Magnesium helps stop twitches, cramps, and fascilations, reduces pain, lowers blood pressure, and prevents heart disease. Take a formulation of easily absorbed acid salts or chelates. Potassium, calcium, and magnesium are all required for muscle and nerve function. Potassium is in most fruit and vegetables. Too much Ca/Mg can cause kidney stones. The proper ration is two parts of elemental calcium to one of magnesium. A caution: magnesium citrate is a potent laxative. If you start supplementing with magnesium and get the runs, try another formulation or cut down the amount.
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Fish Oil
1000 mg 2-3/day
Antioxidant. Promote joint health, circulatory system health. Anti-inflammatory, anti-arthritic. Omega 3 fatty acids. Specific for neuropathy. Lower blood pressure. Moisturizes skin and makes hair shiny. Is a blood thinner. Ask your doctor if you take prescription blood thinners.
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Flax seed
2 tbsp. day
Omega 3 fatty acids. Helps your digestion, blood circulation, general nerve and muscle function. Flax seed has lignins which provides cancer protection.
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Milk thistle
200 mg-70% 3/day
Stimulate and promote liver detoxification. Use only if needed: if the liver is sore or if you were exposed to toxins or drugs.
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PB-8 or other probiotic formula.
1 or 2/day
Probiotics-ensure good amount and healthy balance of intestinal bacteria. Healthy intestinal bacteria produce many nerve essential compounds. Live culture yogurt is a probiotic that has the same beneficial effect, if you can handle the small amount of milk sugar in it.
------------------
Coenzyme Q-10
50 mg, 2/day. Necessary for muscle and nerve function. Compensate for depletion caused by some drugs such as statins.
------------------
DHEA
50 mg. in morning on empty stomach
Promotes healing, energy, libido. Most people over 50 need to supplement with DHEA. Recommended by Life Extension Foundation for peripheral neuropathy.

This list is from Wings 42 in the sticky section back in 08 . Only one I don't take is SAME because it's expensive. This is in addition to 3600 of Gabapentin.

There is evidence that inosine can help in treatment of spinal cord injury.

Inosine – a Multifunctional Treatment for Complications of Neurologic Injury - FullText - Cellular Physiology and Biochemistry 218, Vol. 49, No. 6 - Karger Publishers

There is a general discussion of self-medication with inosine here.

Inosine: Uses, Side Effects, Interactions, Dosage, and Warning

Hey Ricky,

This is a great post by Wings 42 and he has 2 other "sister" posts too that are very useful.

Some thoughts...

B- Complex. I didn't know what B-50 and B-100 meant. Not sure we use that in UK. Then I looked at my own B Complex I managed to get pretty cheap through HealthMonthly because it was nearing its use by date. Its Swanson B-125 meaning it has 125mg of everything. (imported from USA) The tablets are huge and they stink. So for example each tablet contains 125mg of Thiamine. That's a whopping 10,417% of our daily needs. B vitamins are water soluble so we pass them out in our urine. We don't store B Vitamins and There's no way our body can absorb that much. Unless you like urine the colour of a Chernobyl puddle, its crazy to take them in one go. It's literally money down the drain. I cut my tablets up and have say a fifth of a tablet with each meal and with a drink before bed. This ensures a steady supply and saves money.

Flax seeds. Flax seeds are loaded with Omega 3. They take some getting used to and its essential to drink more water. In addition, the Omega 3 and other nutrients are far more bio available if the seeds are ground or milled. I Have a nutri bullet and grind my own Flax. It's not quite as good as shop bought, but does the job. Store them in an air tight container. I add mine to porridge oats.
But why stop at Flax seeds? Also add Chia seeds and ground hemp powder and home milled mixed seeds plus cacao powder. Cacao is a superfood and is so rich in magnesium and calcium that it renders a supplement unnecessary.

Probiotics. Its essential to develop a good microbiome,and have friendly gut flora. Its no good taking a probiotic unless you have a diet rich in fibre because the probiotics will die. Fortunately if you eat oats and flax, fruit and vegetables etc this promotes a healthy environment for probiotics.
You need a probiotic that can survive stomach acid, from memory my research led me to Bio Kult. (Amazon) For supermarket probiotics in UK the only one guaranteed to survive stomach acid is Yakult.
Once you have established a good microbiome you don't need probiotics but I take Yakult as insurance.

Wings 42 also had some good things to say in other (consecutive) posts. It might be worth reproducing them too. Great find Ricky.

Things have taken a strange shift. I started taking my blood pressure meds at night and now I only need all the supplements occasionally . 2-3 times a week instead of everyday. No idea why this works,

rickyc4: Whatever is working that is good. I take 2 BP meds , Atenolol in morning and Amolodipine evening and this routine works in my life. And most days 500mg Inosine for thigh burn, but do use Topicals to calm the burn/tingle issues.

I've been taking 1500 in the morning along with 900 gabapentin and really like the result. Adding compression socks is a plus too.
I take the inosine every other day, with the Wings 42 list of supplements on the alternate days.
I have concerns of Inosine creating kidney stones, which is listed as a possible side effect. I eliminated calcium from the supplements to help.
Just reporting what is working for me.