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So much to consider

Looks like we will have to attack this on multiple levels.

John's PN is from his treatment back in 2002. Lots of drugs complicated with malnutrition. So at this point, I don't think he has an autoimmune PN issue.

We found out his testosterone is very low also so we hope that by improving that, it will help his cardio profile and possibly increase his red blood cell production.

There also seems to be a possible hypercoagulation issue with his blood. One doc says there is, another says there isn't. I think we need to get the test rerun. Anyway, cancer, infections, chronic illness can cause this apparently. (bad blood draw can increase test results also) According to our doc, when the fibrinogen builds up it prevents good circulation at the cellular level. So nutrients don't get to the cells and trash doesn't get moved out. So John has added in a systemic enzyme to breakdown and clear the fibrin out. This one has me a little nervous though because I'm a worrier at heart and his platelets are still low. But everything I've read about this says it does not impact platelet production or increase bleeding times. I found a transcript of a presentation on the use of systemic enzymes if anyone is interested.

We are taking all of this very slowly, much to the chagrin of the doc. He wants to do multiple things at once and we are pushing back big time. Our experience is that it's best to introduce one thing at time and let it settle in. I'm also a firm believer that if you fix one thing, it can then lead to healing in other areas.

Cathie.....this doc looking for a potential infectious agent that may be lingering and has talked about using Doxycyclin. He says an infection will elevate the CRP. I'm not sure John will go for this though. He'll try herbal remedies first since he's had so many problems with long term use of antibiotic. The last thing he wants is to take a hit on his bone marrow from drugs.

Thank you for all the replies....It really shows how complicated this stuff is and gives me lots to ponder.

Marlene

I hope you are still here Marlene:

I am searching on PubMed today for B6 data for a my thread on the Vitamin forum and ran across this C-reactive Protein paper:

Quote:

Circulation. 2001 Jun 12;103(23):2788-91.Click here to read Links
Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels.
Friso S, Jacques PF, Wilson PW, Rosenberg IH, Selhub J.

Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.

BACKGROUND: Lower vitamin B(6) concentrations are reported to confer an increased and independent risk for cardiovascular disease (CVD). The mechanism underlying this relationship, however, remains to be defined. Other diseases, such as rheumatoid arthritis, are associated with reduced vitamin B(6) levels. Despite a clear distinction in pathophysiology, inflammatory reaction may be the major link between these diseases. We hypothesized a relationship between pyridoxal 5'-phosphate (PLP), the active form of vitamin B(6), and the marker of inflammation C-reactive protein (CRP). We also evaluated whether total plasma homocysteine (tHcy), a well-defined risk factor for CVD and a major determinant of plasma PLP levels, had a possible role as a mediator of this hypothesized relationship. METHODS AND RESULTS: Data from 891 participants from the population-based Framingham Heart Study cohort were analyzed. Subjects were divided into 2 groups according to normal or elevated CRP values: group 1, CRP <6 mg/L; group 2, CRP >/=6 mg/L. Plasma PLP levels were substantially lower in group 2 than in group 1 (mean values in group 2, 36.5 nmol/L versus 55.8 nmol/L in group 1, P<0.001). In a multiple logistic regression model adjusted for tHcy, the association of PLP with CRP remained highly significant (P=0.003). CONCLUSIONS: Low plasma PLP is associated with higher CRP levels independently of tHcy. This observation may reflect a vitamin B(6) utilization in the presence of an underlying inflammatory process and represent a possible mechanism to explain the decreased vitamin B(6) levels in CVD.

PMID: 11401933 [PubMed - indexed for MEDLINE]

P5P can be purchased easily... NOW brand makes a good one.

I will have to look at John's supplements to see what kind and how much of the bio available Bs are in them. He's taking Thorne multi and I know they use bio available Bs in many of their mixes.

Part of John's problem is getting them all down at the recommended dosage. His Exjade puts his stomach on edge.

One question on the folate. Is the folate in uncooked food the bioavailable form? Or does folate from vegetables still need to be converted?

It's so interesting to see how the B vitamins are vital to many aspects of your health.

Thanks....M

I have heard from many places...

including the new lecture I went to 2 weeks ago, that folic acid in food
can be less available than in supplements.

It is very susceptible to loss in cooking, esp microwaving.

So it is better to take it as a supplement.. just to be sure.

My C-Reactive protein was actually normal this week. Of course, this may have something to do with higher levels of Prednisone, which I am trying to reduce as quickly as possible, but then I am back on the Doxy again...

My Internist really scared me though by saying he was worried I would have a heart attack or stroke when it was elevated. I think I understand though that elevations don't necessarily mean that it is in the arteries, but it can be from other things too. Having vasculitis always makes me think that it is vascular though...

MrsD: if you know about this, could you please explain it? If you don't have an infection, does that mean it is in the arteries?

Thanks,
Cathie

Your such a help and so we are blessed...Also Glen i had a room full of
Drs. say the the same thing to me this week exactly what you said.
I would like to know about that Yorkiemon.......Sue

I found this on Doxy while looking for natural ways to lower CRP.

http://www.natural-hrt.com/artman/pu...icle_133.shtml