I don't have time to hang around, but one of those unethical marketers (in my opinion) has again been brought to my attention.

If it seems the product you are considering is being marketed as a new kind of B12 that will get through when others won't, and the word "sublingual" is being thrown around as if it is the magic key, I suggest you get a different product.

TV advertising, high price, automatic shipping are not good signs in my opinion. Some of the better brands won't even use the word "sublingual" on their B12 products because B12 is a large molecule and because the large (1000 mcg or more at a time) dose has been known for many years to treat even severe malabsorption. And that dose of methylcobalamin is even better.

rose

wow Rose i remember,and I was fooled years ago Thank you..Sue

I know you R busy - but.............

I order and take the methyl sublingual from LEF

would you be saying these are of no real benefit as opposed to any other type I can buy that are not specifically sublingual?

Appreciate your comment

Clare (THANKS) Tassie

are really just swallowed.. There is no difference. Except you should do
your dose on an empty stomach...that way the B12 can be absorbed better.

I chew mine up and swallow.

So, Mrs D. you don't sit with that stupid pill under your tongue, waiting for it to disolve? Sometimes I get bored and chew it up too. And here I thought I was cheating. It's ok to do that huh?

don't think the sublinguals absorb much.

The whole technology for sublingual is very small. You notice there are
not many things available that way. Nicotine and nitroglycerin are the basic
only ones.

OTC products like we see for B12 don't have to provide bioavailability data
to sell them. Because B12 is a huge molecule, and the mouth surface is small,
I don't expect much gets in that way. I think most is dissolved in the saliva and swallowed. So just see that you take it on an empty stomach for best results.

I think the "sublingual" selling point is to make B12 seem more spiffy, increase patient believeability.

You know many decades ago there were buccal testosterone tablets for men.
They didn't work and were taken off the market.
We don't see other drugs that have minute doses used under the tongue.
Birth control pills for example.
Nitro is under the tongue for immediate angina treatment, but is very short acting and has side effects (it bypasses the liver that way). There are oral forms for longer duration. B12 doesn't need to bypass the liver, (this is called first pass--everything from the GI tract goes thru the liver first ) because the liver is where B12 is stored and converted. Studies have shown that oral swallow gives the same benefits. So I think the sublingual is just a marketing ploy to look "spiffy".

You might want to google sublingual medication. I was surprised at what came up. There are a good number of meds given in this way. For example:
http://www.nlm.nih.gov/medlineplus/d...r/a605002.html

And this one too:
http://bja.oxfordjournals.org/cgi/co...tract/55/8/761

Found this last one (above) interesting just from a clinical standpoint.

This one I didn't know about either. They give allergy meds this way too and it works better than taking them orally.

http://www.webmd.com/allergies/news/...-without-shots

One study I came across stated that giving meds this way even fairly large molecules are absorbed. They didn't give many examples and the article was quite technical really. And it focused on the buccal mucosa as the delivery system....
http://www.ualberta.ca/~csps/JPPS1(1...ccalreview.htm

I'd like to see more info specifically about B-12. I've been hearing about the sublingual form for quite sometime. Just wish I could remember *where* I heard it or saw it!

I *did* find an article that stated: ...no difference in efficacy between the two methods of vitamin complex delivery.

http://www.medscape.com/medline/abstract/17109579

A very interesting discussion! Thank you!