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#31 | |||
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Wisest Elder Ever
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This is a pretty good explanation of nociception:
http://en.wikipedia.org/wiki/Pain_and_nociception And this on dopamine. Dopamine is a pretty complex subject and involves alot of chemistry. http://en.wikipedia.org/wiki/Dopamine Every patient reaches a point in pain perception, that is unique to them, where intolerability occurs. The concept of chronic pain is very hot right now in professional circles. Many continuing education requirements for relicensure in most states for medical professionals, require at least one course in chronic pain management now. Acute nociceptive pain that is not treated properly is thought to be a trigger for chronic pain. However, using opiates for certain forms of pain prematurely, can increase the number of pain receptors centrally and lead to a vicious circle for the patient. I attended a chronic pain seminar last spring, and this factor was discussed at length. In the area of chronic headache, use of opiates actually CAUSES more headache. The tertiary clinic that sponsored this lecture along with the Univ. of Michigan takes all patients OFF narcotics when they enter their program. They have found that use of narcotic meds twice a week can induce chronic headache. I believe the continued research into the central pain pathways that become abberant in chronic headache, will lead to better management of neuropathic pain. Some of neuropathic pain is nociceptive. That is it can be blocked in the periphery with Lidocaine, menthol, for example. Shingles pain is the classic presentation, of nerves that become damaged in some way by the herpes zoster virus and keep firing when they are not supposed to. And some of neuropathic pain is central. So that the medications for this problem involve both methods of pain control. And as we all know, this is not an easy subject and varies from person to person. I personally wish that the research finds ways to heal us. Not just block the central problems. Medicine always seems to go toward the short fix first. When the long fix is discovered, PN then may approach a "cure".
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei ************************************ . Weezie looking at petunias 8.25.2017 **************************** These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
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#32 | |||
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Junior Member
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#33 | |||
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Wisest Elder Ever
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Are you talking about narcotics?
If so, then you should consider a Fibromyalgia diagnosis also. This disorder ramps up pain perception up to many times normal for these patients. Typically narcotic pain relievers do not work for these patients, because endogenous endorphins are very high and sitting on the receptors. Other methods of pain control are then used: This thread explains some of it: http://neurotalk.psychcentral.com/thread20030.html With fibromyalgia there is often a trigger in the body that sets off the pain cycle. It can be arthritis, PN, a car accident or trauma, even a vaccine. A person can have multiple diagnoses.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei ************************************ . Weezie looking at petunias 8.25.2017 **************************** These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
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#34 | |||
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Junior Member
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#35 | |||
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Magnate
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Painkillers is a wide net. What kind of medications caused this?
My next thought is, have you been tested for acute intermittent porphyria? |
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#36 | |||
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Junior Member
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~~ All opiods (< or opiates) not sure what you call them,but you get the drift.As for being tested for Acute Intermittent Porphyria I have never heard of it,so my answer would have to be no......Liz.
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#37 | ||
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Magnate
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Hi. I can relate about meds. I am not at the same point I was last year pain wise thank goodness. At one time last year I cried through vicodin every few hours. I have tried contless meds with little success actually better off them all together. This is why my docs have encouraged a scs or catheter, Right now for me that is to big but have you looked into something like that if it is right for you. I was also told cause some of my syptoms though have pn alo lead to fivro which meds don't help for.Mrd D at the Cleveland Clinic too they take all patients of those meds too and you have to learn to retrain your brain.That with those meds your brain becomes extra sensitive to pain. Maybe I am off. I was a little out of it in pain during the lecture.
Hang in there I do know the trapping fear of nothing helping the pain. I hope you do find what works for you |
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