@Idiopathic: Just wanted to say that, while you may feel alone, you are not, and this forum is a great place — one of the few, certainly — that offers both sensible, well-considered information and a sense of real, respectful community.

Good luck.

mrsD, are you saying this because Idiopathic has so few choices in his schedule? Because I thought that you had said that B12 should be taken alone because the r-lipoic might have inactive ingredients that would interfere with the absorption of B12.

Thanks.

Idiopathic has very few windows of opportunity, with all that fiber and calcium.

There is very little in the Lipoic to affect B12. B12 is absorbed by food and fiber, reducing availability to the passive action at the villi of the intestine. It is a mechanical thing like a sponge.
This is assuming that the intrinsic factor is not working.

The other option is to only take fiber once a day.

Then, could I take B12 with r-lipoic and Acetyl l-carnitine?

I would think so. As long as you take lots of water, to dilute them all out. Say 8 ounces.

Fiber is a no no. Volumes of food are problematic, etc.

Acetyl Carnitine I think can be taken with food. It is the lipoic that has the solubility issues.

However, this link suggests empty stomach for the carnitine, but not
absolutely:
https://physicianformulas.com/store/...p?idproduct=17

This is interesting. The link above says not to take acetyl carnitine with anti-seizure meds at the bottom of the page.

That comment is because they don't know the answer.

In fact one seizure drug, Depakote, has been shown to DEPLETE
carnitine. There have been deaths from this.

Like I said before, the sites on supplements can all vary.
Notice also it is for "seizures" the warning was made.
Not for people take anti-seizure meds for PAIN control.

No one really knows what causes some seizures in humans. Some triggers are never discovered. These doctors have liability attached to giving advice on the internet. There are always disclaimers when doctors are involved.

Thank you.

Tonight is bad for my pain. I could not sleep due to the prickly, jabbing "pins and needles" in my legs. My feet are painful.
It is during this moment that even how much I try to be inspired or keep my head/spirit up, it is just so difficult.

It is harder because I see my husband suffers too.

Mrs. D, can I use 2 hours as window between calcium and gabapentin? And 2 hours between fiber supplement and gabapentin?

Thank you.

Though you mentioned that Depakote has shown to deplete carnitine when its used for seizures ....does this also apply to gabepentin?

Thank you.