for supplements (non drug interventions) that will work equally for everyone.

The causes of PN are many. And people all vary in diet and metabolism, and genetic details.

There is a trend showing however that drugs and some toxins may poison mitochondria, so that using supplements that target them, may help.

But there are vitamin deficiencies due to disease (pernicious anemia), or drug use (use of acid lowering drugs), genetic inheritance of genetic errors that then necessitate higher doses (B6, folate), malabsorption due to gluten, fructose intolerances, or Candida infection. There are diseases like insulin resistance, diabetes, hypothyroidsim, that contribute to PN.

So it becomes a complex issue, and a recipe cannot be crafted to fit all people. Each needs special consideration.