I feel this way too. My doc said too I have been tested as you say up the wazoo(I like that). He was like only thing left to do is take apart your body. The famous words this is chronic. I am like I am 30 and I have 80 year old issues is this normal. A blank face I get. Sorry my rant.
Savannah I heard and have a lot of similar issues and not so much concrete anyhow I hear it can take years and years to get a dx. You may have said but have you sent your records to major places like Mayo?As for fatigue I feel this way too but am not sure if it is from being in so much pain or if it is something seperate. That is the frustrating issue when something happens I don't know if it is a connection between issues or something seperate. Most docs just look at there specialty and don't look outside the box. They go to school for so many years to learn about the whole body too but don't or even give a direction sometime.Random have you tried doing a gluten free diet to see if you feel better? Even though I was tested and don't have at one point I was thinking of trying it. I may still cause I have had major stomach issues this past few weeks as well as everything else. Feel better

Just saw my internist who out of blue of the blue has decided its chronic fatique and PN. I was stunned because I don't fit the syndrome and its means there's nothing to do. Its way to early to give that hopeless diagnosis just because I had this fatique. so now i need a new internist. I didn't even get to tell her my symptoms she had a speech prepared. so I take that as fed up with my troubles and I'll need someone a little more interested. Sometimes I think a young doctor is better, fresh ideas and still excited about medicine!

Meds play a part in the disease itself
 

Leslie, I would like to ask, before commenting, what meds have you been on in the past and what meds are you on now?

The meds I am taking now are:

levoxyl -150 mcg a day for an underactive thyroid, diagnosed 20 yrs ago
amitriptylene - 25 mg a day
tramadal - 50 mg every 8 hrs as needed for pain
lyrica - 75 mg twice a day
gabapentin - 900 mg 4 times a day

I am on the gabapentin and lyrica as I am transitioning from gaba. to lyrica.

I was diagnosed with H-Pylori back in Jan 2008, and was started on the medication Helidac. However, I still think I have H-P as the initial symptoms I complained of back then are back. I have an appt on 9/22 with my doc and I plan to ask him to do another blood test to see.

From late 2006 to June 2008, I was on Celebrex 200 mg a day for athritis in my left knee. At an ortho doc appt in June 2008, he advised that I do not have arthritis but had fluid on my knee. At that point I stopped with the Celebrex.

Other than taking eleve for random headaches I haven't been on any meds long term.

I know this is more that you asked for by my thinking is swiss cheese lately and it helps to line it all out!

sorry for taking so long to get back to you Leslie, for a while I had lots of trouble typing in my user name and getting all the threads I posted in to show up, so I lost track of this one...but it seems to work now.

Meds like amitryptiline, lyrica and gabapentin can affect the sphincters and how they work in the body. Anticonvulsants and antidepressants and for some the benzodiazepines can affect the spasms occurring in the body's sphincters, and muscles (relaxing/calming/quenching burning and spasms/cramps).

So, when the levels of these drugs increase or decrease ( either through adding another medication that can interact with these) then you can get less or more spasms/cramps/burning.
so if your oesophageal sphincter started to spasm and oesophagus spasms and bowel spasms it would explain you throwing up.
The helicobacter drugs could've interacted to cover you better or/and seeing you're switching to Lyrica... you could be not on the equivalent dose of neurontin you were on yet and your body is withdrawing from the neurontin.

People with neuropathic pain who have been on these meds for long periods become centrally sensitized if they weren't already to begin with due to their injury and it can spread to other parts of their body. Internally, the gut contains nerve receptors that don't respond the same way ...everything slows down (slows down cramping/spasms/) and GI tract slows.

I don't know how the thyroid meds would affect this process...perhaps lookin up their side effects will give you an idea.

I'd Keep away from all stimulants coffee, sugar etc and try to keep your body on the alkaline side as much as possible....no laxatives either...this can start off the vomiting during the bm. THere is also a connection between the enteric nervous system (ENS) and the central nervous system (CNS), I understand it occurs through the vagal nerve. THis can explain vasovagal syncope (complete blackouts) or to a lesser extent, dizziness and starting to throw up, whilst having a bowel motion.
This is very scary, I know. Hope some of this helps. Take care.