NeuroTalk Support Groups - A bit off topic, suitable birth control method for someone with neuropathy?

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- - A bit off topic, suitable birth control method for someone with neuropathy? (https://www.neurotalk.org/peripheral-neuropathy/73985-bit-topic-suitable-birth-control-method-neuropathy.html)

Quote:

Originally Posted by Monica de Lara (Post 455333)

Leslie and Dutch woman, how longhave you been suffering from neuropathy? You say you've been taking Depo Provera shots for a year. Maybe there's a link.

Of course I already thought about a link. My neuro knows that I use Depo and we never tried to stop and experience if there is a difference. Also on the internet I don't find anything about a link, but perhaps there is. When they really don't find a cause for the sfn, I think I want to try 3 months without Depo, but I can start that proove not earlier than April; I just had an injection.
I cannot imagine that this is the cause, because I never feel a difference when I just had the injection, but it could be. It's worth trying.
I take Depo for 2,5 years now and I have sfn since 1,5 year.

found that giving experimental rats with induced pain, that the pain was made worse by Provera:

Quote:

Neurobiol Dis. 2008 Apr;30(1):30-41. Epub 2007 Dec 14.Click here to read Links
The biological activity of 3alpha-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury.
Meyer L, Venard C, Schaeffer V, Patte-Mensah C, Mensah-Nyagan AG.

Equipe Stéroïdes et Système Nociceptif, Institut des Neurosciences Cellulaires et Intégratives, Unité Mixte de Recherche 7168/LC2-Centre National de la Recherche Scientifique, Université Louis Pasteur, 21 rue René Descartes, 67084 Strasbourg Cedex, France.

Identification of cellular targets pertinent for the development of effective therapies against pathological pain constitutes a difficult challenge. We combined several approaches to show that 3alpha-hydroxysteroid oxido-reductase (3alpha-HSOR), abundantly expressed in the spinal cord (SC), is a key target, the modulation of which markedly affects nociception. 3alpha-HSOR catalyzes the biosynthesis and oxidation of 3alpha,5alpha-reduced neurosteroids as allopregnanolone (3alpha,5alpha-THP), which stimulates GABA(A) receptors. Intrathecal injection of Provera (pharmacological inhibitor of 3alpha-HSOR activity) in naive rat SC decreased thermal and mechanical nociceptive thresholds assessed with behavioral methods. In contrast, pain thresholds were dose-dependently increased by 3alpha,5alpha-THP. In animals subjected to sciatic nerve injury-evoked neuropathic pain, molecular and biochemical experiments revealed an up-regulation of 3alpha-HSOR reductive activity in the SC. Enhancement of 3alpha,5alpha-THP concentration in the SC induced analgesia in neuropathic rats while Provera exacerbated their pathological state. Possibilities are opened for chronic pain control with drugs modulating 3alpha-HSOR activity in nerve cells.

PMID: 18291663 [PubMed - indexed for MEDLINE]

That level of English is too high for me I guess :D but I let my neuro read. Thanx!

Quote:

Originally Posted by FlyingDutchWoman (Post 455935)

That level of English is too high for me I guess :D but I let my neuro read. Thanx!

FlyingDutchWoman -

Don't fell bad about your english. I have spoken english for over 45 years and the medical jargon is always hard for me to understand also!!

Leslie

Quote:

Originally Posted by Koala77 (Post 454735)

I think for those inclined to heavy bleeding, they wouldn't be an option as they can make bleeding heavier, but for others it might be worth a try.

Precisely, and that would let *me* out. BC has been a problem for me all my life. I have 6 kids to prove it. :o Hurry up menopause!! :D

Quote:

Originally Posted by glenntaj (Post 454954)

--get the gentleman involved to take some responsibility. :D

The combination of a diaphragm and condom is at least as effective as most other methods.

*snerk* :D You're kidding right? I think that's why the male pill was such a failure. How many women do you know that would trust a man to take a pill every single day? After all, at the end of the day it's still we women that get pregnant.

The Mirena, an iud, is actually designed for women with heavy bleeding, as it contains a resevoir of a progestin that slowly leeches out and is applied directly to the endometrial lining. Many women stop bleeding altogether and stop menstruating while they are using a mirena. This is quite different from the regular type of iud which does tend to cause heavy bleeding.

I have never noticed any relationship between hormones and my neuropathy, my neuropathy just seems to keep trucking along no matter what does or doesn't happen on the hormonal front.

cheers

raglet

No, not kidding--

--though yes, I recognize many men would not take a daily pill.

But that doesn't mean they shouldn't use condoms. And there's nothing wrong with women keeping a supply of those around, either (especially if one is not in a committed relationship). They provide some protection against other nasty things besides pregnancy.

If the man refuses to wear one, well, screw him. (Actually, don't.) :p

I'm not a big fan of Mirena, I just told in another topic a few days ago: click

I don't know if it has something to do with my neuropathy, but for me it feels like it has. I have always been very sensitive to things that other persons even don't feel, for example at the dentist's.