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-   -   Mitochondria: (https://www.neurotalk.org/peripheral-neuropathy/80999-mitochondria.html)

Sallysblooms 01-25-2012 12:25 PM

The ALAMAX Cr by Xymogen is the Alpha Lipoic Acid my integrative doctor likes the best. That is 600mg of slow release.

In the afternoon, I take a 300mg of another brand.

I buy my Whey Protein and my Benfotiamine from LEF. My doctor likes those from LEF.

Nervous 01-25-2012 12:42 PM

@Sally: Granted, we are talking about ALA, not r-lipoic, but these doses are higher than I would have expected.

@everyone: What is the current consensus about daily doses for ALA and r-lipoic?

Sallysblooms 01-25-2012 12:52 PM

Looks like the ALA MAX has both kinds of Lipoic Acid.I think the one I take in the afternoon is the reg. Alpha Lipoic Acid. Designs for Health brand. For healing neuropathy the dose is 600-1800mg.

My Xymogen is good since it has the Biotin. Designs for Health does too. Biotin can be low when taking Alpha Lipoic Acid.



http://www.xymogen.com/2008/formula.asp?code=000096

NeuroLogic 01-25-2012 01:48 PM

Quote:

Originally Posted by mrsD (Post 844904)
I agree about the Benfotiamine. I use 150mg a day. It has been useful for me too.

LEF also is now newly offering stablized R-lipoic acid:
they call theirs "super".

http://www.lef.org/Vitamins-Suppleme...poic-Acid.html

I'm trying their Super stuff now. But I'm taking so many supplements it's difficult to know what all is working, and which stuff is doing the heavy lifting.

Here's a quote from a fascinating article I just read on mitochondria:

Quote:

"Now a study led by investigators at Beth Israel Deaconess Medical Center (BIDMC) suggests that mitochondria -- the body's cellular "power plants" -- are released into the bloodstream following physical injury. And because mitochondria closely resemble the bacteria from which they originated (!) they appear to elicit a sepsis-like immune response, changing from a vital source of cellular injury to a dangerous "enemy within."

mrsD 01-25-2012 01:59 PM

Quote:

Originally Posted by NeuroLogic (Post 845020)
I'm trying their Super stuff now. But I'm taking so many supplements it's difficult to know what all is working, and which stuff is doing the heavy lifting.

Here's a quote from a fascinating article I just read on mitochondria:

Yes, that is really fascinating. Thanks for posting it!

Your mitochondria only carry DNA from your maternal ancestors.
They do not have YOUR DNA in them.

This thread just gets more interesting every day IMO!

NeuroLogic 01-26-2012 02:58 PM

I saw a new naturopath today. She's better than the last one -- more scientific and into advanced diagnostics. Her background is in medical research, which I thought was ideal (and better than other local NDs). We talked about the basics and mitochondria testing.

I've also looked at Dr. Sarah Myhill's mito testing, but it may be more expensive, and certainly more complicated. She says you're supposed to ask the courier to keep the blood samples in the cockpit (!) or somewhere not in the hold; otherwise the samples get ruined. I'd rather not have to take chances on communication or somebody's memory. Hopefully I can find something closer and convenient.

They drew four vials; two are for local Gamma/Dynacare basic tests; two were Fedexed out today for SpectraCell Laboratories.

The first test is for most of the basic minerals and heavy metals.

She seemed to think the heat issue could be related to constantly stimulated, albeit modestly, adrenal glands. She had a diagram and the idea sounded reasonable. (I seem to feel warmer after stress.) We're starting with saliva testing but also looking into the source, be it a toxin, allergen, whatever--perhaps a combination of factors. The SpectraCell results are to be expected in a few weeks.

Omega 3/Fatty Acid tests are also being considered for the future. I told her I want my membranes tested and she has an Oxidata panel I'd check out later when the kit arrives. It is supposed to reveal info on how badly anti-oxidants are needed. It's not free but it sounds radical. :)

NeuroLogic 02-12-2012 08:59 AM

Cells' energy factories linked to damaging inflammation

"Scientists have discovered that molecules called reactive oxygen species (ROS) produced by the energy factories, or mitochondria, in cells, may play a role in a rare inherited disorder in which uncontrolled inflammation damages the body’s tissues."

"If not controlled, inflammation can lead to amyloidosis, a buildup of inflammatory proteins that can result in organ damage."

Idiopathic PN 03-08-2012 08:18 PM

Quote:

Originally Posted by mrsD (Post 835908)
I do think it is worth while to test mitochondria in patients with chronic low metabolic symptoms.

I am not sure about all the statements you are quoting, however.
Some forms of PN affect the autonomic nervous system itself and therefore sweating would be affected.

Let us know what the results are, in any event.
And your research is very helpful here...please do keep that coming. In medical systems, often factoids are scattered about and may not be understood properly. " The B12 on an empty stomach" is an example. Research with drugs in microgram amounts/doses showed poor or no absorption when food was present in the GI tract.(thyroid hormone and digoxin) This is a huge issue with the microgram amounts of B12 we need to absorb orally. But this evidence so far is not connected to B12 information (except for me) it appears!

Mrs. D,
Is there a test to determine if your mito is damaged? If yes, what is it called?

Thanks, as always.

mrsD 03-09-2012 12:51 AM

For people with DNA genetic damage to mitochondria there are muscle biopsies to determine if the mitochondria are missing etc.
The biopsies are complicated and have to be done in a special careful way too.

But for general purposes, no, there are no other specific tests that I know of.

For now we have only hints when you respond to mito support nutrients in a positive way, that implies mito functions are
compromised.

http://my.clevelandclinic.org/disord..._diseases.aspx

Idiopathic PN 03-09-2012 05:57 AM

Quote:

Originally Posted by mrsD (Post 859314)
For people with DNA genetic damage to mitochondria there are muscle biopsies to determine if the mitochondria are missing etc.
The biopsies are complicated and have to be done in a special careful way too.

But for general purposes, no, there are no other specific tests that I know of.

For now we have only hints when you respond to mito support nutrients in a positive way, that implies mito functions are
compromised.

http://my.clevelandclinic.org/disord..._diseases.aspx

Thank you Mrs. D! I sincerely appreciate your help.

I read last night in one of the posts here (sorry I forgot now who posted it or under what topic - since I started taking gabapentin, my memory really became bad) , it says about cruciferous vegetables not good for hypothyroidism. It also mentioned about it being steamed or eaten raw, does it mean that its okay to cook it in other ways e.g. sauteing.


Thank you.


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