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Old 08-25-2009, 02:14 AM   #11
mrsD
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There has been some evidence that folic acid supplements work better than food.

Here is a recent article about vitamins vs food:

http://www.healthnewswebsite.com/nut...pplements.html

Quote:
For example, the absorption of the synthetic form of folic acid found in supplements or fortified foods is considerably better than that of food folate. In another example, the Institute of Medicine advises adults over age 50 to obtain vitamin B12 mainly from fortified foods or supplements containing B12. This is because age-related loss of stomach acid in some older individuals may reduce the availability of B12 from food sources.
Some people cannot methylate B12 from the commercial cyanocobalamin type of B12. This is why methylcobalamin is a better choice to use. Since MethylB12 is so inexpensive, there is no reason NOT to use it.
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Old 10-03-2009, 08:32 AM   #12
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How long should you wait to eat after taking B12 in the morning on a empty stomach?
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Old 10-03-2009, 09:02 AM   #13
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At least 1/2 hr , but 1 hr is better.

The micrograms of B12 can be lost in food. Microgram dosing of drugs has been found to be severely impacted by presence of food. Esp fiber foods that breakfast often has. Micrograms is a very very tiny amount of anything. Because I know this from my training...I push the empty stomach factor. I have not seen any of the OTC websites picking this fact up for B12...and it has been over 5 yrs now since it was known for drugs. That just illustrates how medical info can get walled into little niches and not applied to other situations!

I had a patient in a clinic once whose doctor kept raising her thyroid dose. She was at .225mg which is really high.. and getting no response. Turns out she was taking it with Oatmeal!
She was a young woman with an intact thyroid...no Hashimoto's either. She ended up well, finally at .1mg where she belonged, after I intervened.
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Old 10-03-2009, 10:05 AM   #14
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Originally Posted by mrsD View Post
At least 1/2 hr , but 1 hr is better.

The micrograms of B12 can be lost in food. Microgram dosing of drugs has been found to be severely impacted by presence of food. Esp fiber foods that breakfast often has. Micrograms is a very very tiny amount of anything. Because I know this from my training...I push the empty stomach factor. I have not seen any of the OTC websites picking this fact up for B12...and it has been over 5 yrs now since it was known for drugs. That just illustrates how medical info can get walled into little niches and not applied to other situations!

I had a patient in a clinic once whose doctor kept raising her thyroid dose. She was at .225mg which is really high.. and getting no response. Turns out she was taking it with Oatmeal!
She was a young woman with an intact thyroid...no Hashimoto's either. She ended up well, finally at .1mg where she belonged, after I intervened.

Hi Mrs. D.

You probably saved that woman's life.

I take the Methyl B-12 as soon as I get up in the morning. Under my tongue. Around 8:15 a.m. By the time I take my walk to my local little breakfast nook where I have my one egg (or egg white), with my sliced tomatoes ( I bring a cup of my sprouts), and sprinkle on top). Well, it's about one hour after I do the Methyl B-12 that I have my breakfast.

For me, it works just fine.

I take 5000 each and every day. So far, no side effects, just good energy and no pins and needles and tingling.

Oh, on an interesting note, last night Alan said "my feet don't burn, they just tingle". I said "what do you mean your feet don't burn, I thought that's what they've been doing for 18 years because your neuro diagnosed you with small fiber (I think large fiber too, but I'm not sure).

He said 'what exactly do you mean when you say BURNING".

So I said "well, in my case when the weather is not cooperating, my whole foot burns for two seconds. NOTHING COMPARED to what it did when I was first diagnosed with Diabetic Neuropathy two years ago.

I immediately went on the Methyl B-12 and the rest is history. He tried it but nothing happened.

So I do get very few episodes of slight burning, but it's NOTHING. Maybe they are healing? Who knows. I certainly can live with it because I dont' get the zipping zapping, etc.

Alan, on the other hand explained that what I thought was BURNING in his case, turned out to be EXTREME TINGLING. So when Alan says to me "My feet are doing a dance", now I know he means TINGLING and not burning.

God only knows, I would have spent the next 18 years thinking this guy's feet were on fire, and they were REALLY TINGLING LIKE CRAZY.

Neuropathy is a very weird disorder.

Melody
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Old 10-04-2009, 11:50 AM   #15
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Default Very Good Information

Thank you for being such a help!
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Old 10-09-2009, 12:52 AM   #16
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Lightbulb Something new is coming!

This company is releasing a new B12 oral delivery system:

http://www.emisphere.com/eligen.html

A new way to deliver B12 orally, using lower doses.

http://www.businesswire.com/portal/s...23&newsLang=en

http://www.emisphere.com/eligen_library.html

This company is trialing a 5mg dose form...
http://www.emisphere.com/oral_vitamin_b12.html
Quote:
Emisphere's pharmacokinetic study demonstrated that mean Vitamin B12 peak blood levels were more than 10 times higher for the Eligen® B12 5mg formulation than for the 5mg commercial formulation (12847 pg/ml and 1239 pg/ml, respectively). The time to reach peak concentration (Tmax) was reduced by over 90%; the mean was 0.5 hours for the Eligen® B12 5mg and 6.8 hours for the commercial 5mg product. Mean AUC_(24h) values were 54618 for Eligen® B12 and 23131 for the commercial 5mg product. Improvement in bioavailability was approximately 240%, with absorption time at 30 minutes. The study was conducted with a single administration of Vitamin B12; there were no adverse reactions, and Eligen® B12 was well-tolerated.
But it is unclear if it is methyl or cyano at this time.

I expect this will raise costs, to those who take B12, but it appears to be an improvement in absorption.
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Last edited by mrsD; 10-09-2009 at 11:32 AM.
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Old 10-09-2009, 10:32 AM   #17
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Quote:
Originally Posted by mrsD View Post
This company is releasing a new B12 oral delivery system:

http://www.emisphere.com/eligen.html

A new way to deliver B12 orally, using lower doses.

http://www.businesswire.com/portal/s...23&newsLang=en

http://www.emisphere.com/eligen_library.html

This company is trialing a 5mg dose form...
http://www.emisphere.com/oral_vitamin_b12.html

But it is unclear if it is methyl or cyano at this time.

I expect this will raise costs, to those who take B12, but it appears to be an improvement in absorption.

Mrs. D.

I clicked on the emisphere link and read the info.

How exactly is the DELIVERY of this oral B-12 different than what I am doing presently. Taking the Jarrow 5000 sublingually each morning.

Thanks much

Melody
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Old 10-09-2009, 10:40 AM   #18
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The new system is vague...they don't want to reveal their patent IMO.

One of the links shows how their additive enables large molecules to cross membranes in the GI tract.
Up until now, if you have no intrinsic factor working, high dose B12 is only passively absorbed in the intestine. This is why high doses are needed, to push a little bit (less than 10%) into the blood stream. This is why empty stomach is important now with the oral as it exists today.

It appears this technology is going to be applied to insulin and other large molecules that cannot be given orally at this time due to stomach acid and poor absorption.

It appears that the B12 is the first application for this. I guess it will generate some income to support the research for the other uses.

I just hope it is not priced so high as to be out of many peoples' reach. And I couldn't find what type of B12 they are doing either.
I hope it is methylB12.

I think those questions will resolve soon, as it will be out soon.
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Old 11-05-2009, 10:29 AM   #19
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Default Carrot Juice??

I know carrot juice provides lots of vitamin A, but do not know if its B complex vitamins have the B-12.

Does anyone know?

Thanks

PS: Couldn't live without my juicer!!
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Old 11-05-2009, 10:36 AM   #20
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Quote:
Originally Posted by rscowboy2005 View Post
I know carrot juice provides lots of vitamin A, but do not know if its B complex vitamins have the B-12.

Does anyone know?

Thanks

PS: Couldn't live without my juicer!!
I can't imagine any diabetic drinking loads of carrot juice. The concentrated sugar alone would skyrocket my glucose reading.

but I agree. I love my juicer also. I just juice for my husband.

Melody
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