[Nervous]

Originally Posted by MelodyL

I think I learn something from you each and every day. And I now have many people taking Methyl B-12. They went to their doctor, had a blood test and found out that they were INDEED B-12 deficient.

You help a lot of people Mrs. D.

Especially this one.

Take care

Melody

Well said. Same here. I am grateful.

[BlueHill]

Originally Posted by mrsD

Welcome to NeuroTalk:

if you have normal kidney function tests, your use of methylB12 should be fine. Most of that oral B12 is not even absorbed.

People become low if they have autoimmune issues affecting the parietal cells of the stomach. Acid blocking drugs and metformin are also culprits in reducing absorption of B12 from food. Loss of parietal cells occurs genetically also in people who inherit pernicious anemia.

About 30 % of people over 50 may develop low acid in the stomach with aging, and when this happens, B12 cannot be absorbed from food like before. The name for this is achlorhydria.

Many people with only one functioning kidney can have normal functions. You can ask your doctor about your clearance rates. This would also affect many drugs you may use for various reasons.

I'll be back from vacation in about a week or so. We are still in the Northwoods.

Thank you very much mrsD for your reply amidst your vacation. This shows your commitment to help people here. We really appreciate it.
My recent (last month) checkup shows my single kidney is functioning normally. I am not sure about 'clearance rates' you mentioned, I think it is about Creatinine level. Sorry we are software professionals no idea about medical terms. Slowly learing through this forum.
Let me post a few results of my blood test here.

Uric Acid 4.5mg/dL (2.5 - 6.2)(Figures in brackets are the ranges)

Kidney Profile
--------------
Sodium 135 mmol/L (136-405)
Potassium 4.3 mmol/L (3.3 - 5.1)
Chloride 98 mmol/L (95-110)
Urea 24 mg/dL (15-49)

Serum Creatinine
-----------------
Creatinine 0.79mg/dL (0.50-1.20)

Urine test results are all negative.

Currently I am using a single tablet of Telma (Telmisartan 40mg) every day. My BP is always around 100/70. Doctor says it is good use that tablet, but I always doubt that.

I understand, people in this forum are not doctors but sharing our opinions and experiences help us a lot. I wish I should have seen this forum 4 years back. My husband went through a lot. He visited our home country several times only for medical checkups. In our contry of residence medication is expensive and mostly the insurance is covered for inpatients only.

The Methylcobalamin tablets are not delivered yet. Waiting for them.

[BlueHill]

Hi,
Can somebody please clarify whether methycobal is similar to methylcobalamin?
It seems it is going to take long time to deliver methylcobalamin from puritan and we failed to convince the doctor for more shots. Currently I am getting 1ml (1000 mcg) per week.
When I checked in the pharmacy for Vitamin B12 tablets in Singapore they only have cyanocobalamin tablets and methycobal tablets. Both are not sublingual. The methycobal tablets are expensive. 10 tablets costs around USD 5. The pharmacist says methycobal 500 mcg can be taken one tablet 3 times a day.
Please share information on this. thank you.

[mrsD]

From what I see online methycobal is an abbreviation that might be used for methylcobalamin.

That seems pretty expensive where you are.
I'd contact iherb.com and see if they ship to where you
are located. They do to lots of countries in fact.

When you use orally, make sure it is on an empty stomach for best absorption.

Since your serum creatinine is normal, I'd not worry about your dosing.
The high levels do have a function, however. It is not to show toxicity, but to alert doctors to hidden disease states which sometimes show
high blood levels in testing. Kidney failure and some leukemias, and intestinal inflammations from bacteria may show high B12 levels as a sign. The B12 itself is not doing harm, but in people NOT taking supplements may be a signal to do further testing on the patient. Doctors get used to "flagged" results meaning danger...only in this case it is a referred danger and not a toxic one.

[BlueHill]

Thanks mrsD for the information.
Yeah methycobol seems to be the brand name for Mecobalamin. I found the following info
*edit* (can not add links, please copy and paste the text to view)from the manufacturers.
As seen from their website Iherb** ships to Singapore if we order online. As I mentioned, I already ordered from puritan 15days ago, they say they still need 10 more days to deliver here

[Marlene]

http://www.sciencedaily.com/releases...0827074146.htm

[mrsD]

Originally Posted by Marlene

http://www.sciencedaily.com/releases...0827074146.htm

That is really interesting! Thanks, Marlene, for putting it up here.

It appears to be a rare finding, but all information pertaining to B12 is important for us. Many people end up on the net because of some rare issue, that doctors are missing in their diagnostic work ups.

I wonder what the treatment mentioned is...? Maybe just higher doses of the supplement?

I think the genetic information coming out on the human genome will show other genetic errors with other nutrients.
The MTHFR mutations are other examples.

I recall Dr. Bruce Ames PhD stating in a paper on PubMed from years ago that he believes there are genetic errors involving many B vitamins in people, resulting in illness.

[Marlene]

I too was wondering how you treat this. It seems that you never really see any follow up on these articles. At least we are now aware of these types of problems.

BTW....welcome back from vacation.

[julleri]

... Puritan's Pride is having another buy 1 get 2 free sale...

Sale lasts through September 25.

[MelodyL]

Originally Posted by julleri

... Puritan's Pride is having another buy 1 get 2 free sale...

Sale lasts through September 25.

And we bought our vitamins last night. Great deals.

Melody