[reggiejones32]

it was the supplement given to me by my doctor. my blood pressure was a little high while on it also. Do you know of any Hydroxycobalamin supplements also?

Originally Posted by mrsD

Actually methylB12 helps you sleep.
It is part of the cofactor used to make melatonin
From serotonin.

2000mcg of folate is a lot. Why are you
Taking so high a dose?

You can reduce the methylB12 to every
Other day and see how that works.

What else are you taking?

[mrsD]

Yes the hydroxocobalamin is available .

Check at iherb.com or Google it.
It tends to be more expensive.
There is also adenosyl form too.

I am on an iPhone on vacation and
Can't link with it.

Try your methyl every other day. If you
Go below 1000mcg not much is absorbed
At all. The link to the table showing absorption
statistics is in the first post on this thread.

[reggiejones32]

ok thanks so much for the information. my last question is will 1000mcg of hydroxocobalamin be enough to raise my levels?

Originally Posted by mrsD

Yes the hydroxocobalamin is available .

Check at iherb.com or Google it.
It tends to be more expensive.
There is also adenosyl form too.

I am on an iPhone on vacation and
Can't link with it.

Try your methyl every other day. If you
Go below 1000mcg not much is absorbed
At all. The link to the table showing absorption
statistics is in the first post on this thread.

[mrsD]

Yes, if you take it on an empty stomach.

Food present will reduce absorption considerably.

Some people react to high dose folate, so
I would keep that in the realm of 800mcg daily.

[reggiejones32]

yea the supplement that I am ordering has 1000mcg of folate. hope that isn't too high is it?

Originally Posted by mrsD

Yes, if you take it on an empty stomach.

Food present will reduce absorption considerably.

Some people react to high dose folate, so
I would keep that in the realm of 800mcg daily.

[derek123]

Hi MrsD, first time poster. I found this thread like many others I assume. Ill try to keep the post short and any advice is appreciated.

About 2 years ago I started feeling symptoms - faint weakness on the outsides of my hands feet (which I assume is per neuropothy). The symptoms gradually started to include the aura migraine types - such as difficulty speaking, trouble with basic motor skills on occasion, slight lack of balance. Then they started becoming difficulty focusing, multitasking, short term memory issues. One of the continuous symptoms throughout was a pressure behind my left eye. Maybe more of a sensation/disturbance than a pressure. But all those things added up to difficulty processing things visually. Driving certainly made a bit more difficult. Just doesnt feel like my eyes and brain are focusing 100%

Finally after about a year I decided to start getting this stuff checked out. Not sure why I didnt earlier. Could still function but started to realize not the same way I had a couple years before.

Doctor ordered the usual labs and first thing he even thought was B12 def. I got CT scan for the bigger stuff such as MS and tumors but all that came back clean. Blood work showed no diabetes and the like.

However my B12 levels were 254 (range 180-900). Doctor argued its not deficient but sometimes people become sensitive at different ranges. He ordered the Homocysteine and Methylmalonic Acid tests. Those came back 13.0 umol/L and 88nmol/L respectively. He had no comments on those other than they were normal. He told me to take over the counter B12 1000mcg and I did (cyano) for about 3-4 weeks. I didnt notice any major changes in symptoms so I quit taking it. I even told the doctor this.

This was all done back in December 2013 BTW. After that he sent me to the nuerologist. She basically started working the Migraines angle since the symptoms matched up for the most part. Took Lamictol or whatever its called for about 1 month with no effectiveness.

Next step she sent me to the Nuero Optomologist and that came back perfectly fine.

Finally at my early August 2014 visit to the Neuro (my 4th total vist) which is now 9 months after I went in for these symptoms back in December I straight out asked her before she went any further if these symptoms could have to do with B12... I said I did quite a bit of reading online about levels under 400 possibly causing nuero symptoms. More or less I almost got the impression when she re-looked at my december labs that she had overlooked my levels completely. She then gave me the liquid through the nose 500mcg Nascobal (cyanocobalamin).

I took two of the injections but after not feeling much better immediately I started doing deeper research on the internet about my symptoms. Basically just became frustrated with the lack of any progress or direction from my doctors. And now Ive ended up here. It seems now, I hope, through my own research that I may be narrowing down the causes. That being B12...

I guess my question is based on what Ive posted here do you have any conclusions or possible advice on how to read this data? I can provide more lab info if needed. I actually had lab work re-done last week to check where my B-12 levels are currently. I just started taking (based on this threads advice) a methlycobalmin form of B12 (to be exact Finest Nutrition brand 5000mcg once a day). I took my first one today.

Thanks again for any advice you can give.

[mrsD]

The methylB12 and any oral should be
Taken on An empty stomach so it can be absorbed .

I'd also take some methyl folate called
Metafolin 800mcg daily.

Your MMA test was in the upper range of
"normal". If you were utilizing it properly
You would show a much lower result-- below 20.

And your homocysteine is high at 13.

Because of that result I think you should
Take an activated B6 called P5P.
NOW company makes it affordably.

iherb.com sells both Metafolin and P5P on line
But they are not typically in local stores.

It takes about 3 months to bring up low
B12. If you have the DNA mutation in
methylation you need both methyl forms
Of B12 and folate.

[Kitt]

Welcome derek123.

[derek123]

Originally Posted by mrsD

The methylB12 and any oral should be
Taken on An empty stomach so it can be absorbed .

I'd also take some methyl folate called
Metafolin 800mcg daily.

Your MMA test was in the upper range of
"normal". If you were utilizing it properly
You would show a much lower result-- below 20.

And your homocysteine is high at 13.

Because of that result I think you should
Take an activated B6 called P5P.
NOW company makes it affordably.

iherb.com sells both Metafolin and P5P on line
But they are not typically in local stores.

It takes about 3 months to bring up low
B12. If you have the DNA mutation in
methylation you need both methyl forms
Of B12 and folate.

Thanks for the advice here Ill take a look .

I forgot to mention my Folate levels on the blood test were 11.0 ng/ml.

[derek123]

Also if you could be more specific about P5P. Any link to a product page? I feel if I search for it ill not end up with the correct suggestion.