[deepak2016]

deepak2016,

I copied your post to the main PN forum area, here is the link to it -
http://neurotalk.psychcentral.com/thread232413.html

[pjlla]

Very interesting. Thank you!. I read a book called VitaNutrients the author was Dr. Atkins who was famous for his low carb diet. Regardless if you like or don't' like this ideas on diets. His book on nutrients I thought was fascinating. He indicated that the thought process for the medical profession was a lack of various minerals or vitamins causes diseases. For example, the lack of Vitamin C causes scurvy. So the medical profession determines what was needed to avoid scurvy and that was the recommended amount. His point, while it may be true you need that much to avoid scurvy. His position was the body needed more to function properly. He did a lot of studying on this and quoted a lot of other doctors mentioning how the minimum people should really take and if you have a disease, then you would need more of certain items. I have taken his advice for increasing items like Fish Oil, Borage Oil, Flax Seed Oil, as well as Vitamin C, D etc. I suggest at least reading his book.

[junkcrap50]

Can taking methylation supplements (B12 and folate) cause small fiber neuropathy or other neuropathies?


I know a deficiency of B12 can, but I test all normal (haven't done urine MMA). But I have had chronic muscle pain ever since taking relatively high doses of methylB12 and methylfolate. I wonder if taking either one somehow drained my B12 and caused SFN. I don't have typical neuropathy sensations, but some SFN symptoms and annecdotally, SFN can present with muscle pain.

[dbw52]

Thank you for being such a help!

[mrsD]

This company is releasing a new B12 oral delivery system:

http://www.emisphere.com/eligen.html

A new way to deliver B12 orally, using lower doses.

http://www.businesswire.com/portal/s...23&newsLang=en

http://www.emisphere.com/eligen_library.html

This company is trialing a 5mg dose form...
http://www.emisphere.com/oral_vitamin_b12.html

Emisphere's pharmacokinetic study demonstrated that mean Vitamin B12 peak blood levels were more than 10 times higher for the Eligen® B12 5mg formulation than for the 5mg commercial formulation (12847 pg/ml and 1239 pg/ml, respectively). The time to reach peak concentration (Tmax) was reduced by over 90%; the mean was 0.5 hours for the Eligen® B12 5mg and 6.8 hours for the commercial 5mg product. Mean AUC_(24h) values were 54618 for Eligen® B12 and 23131 for the commercial 5mg product. Improvement in bioavailability was approximately 240%, with absorption time at 30 minutes. The study was conducted with a single administration of Vitamin B12; there were no adverse reactions, and Eligen® B12 was well-tolerated.

But it is unclear if it is methyl or cyano at this time.

I expect this will raise costs, to those who take B12, but it appears to be an improvement in absorption.

[MelodyL]

Originally Posted by mrsD

This company is releasing a new B12 oral delivery system:

http://www.emisphere.com/eligen.html

A new way to deliver B12 orally, using lower doses.

http://www.businesswire.com/portal/s...23&newsLang=en

http://www.emisphere.com/eligen_library.html

This company is trialing a 5mg dose form...
http://www.emisphere.com/oral_vitamin_b12.html

But it is unclear if it is methyl or cyano at this time.

I expect this will raise costs, to those who take B12, but it appears to be an improvement in absorption.

Mrs. D.

I clicked on the emisphere link and read the info.

How exactly is the DELIVERY of this oral B-12 different than what I am doing presently. Taking the Jarrow 5000 sublingually each morning.

Thanks much

Melody

[mrsD]

The new system is vague...they don't want to reveal their patent IMO.

One of the links shows how their additive enables large molecules to cross membranes in the GI tract.
Up until now, if you have no intrinsic factor working, high dose B12 is only passively absorbed in the intestine. This is why high doses are needed, to push a little bit (less than 10%) into the blood stream. This is why empty stomach is important now with the oral as it exists today.

It appears this technology is going to be applied to insulin and other large molecules that cannot be given orally at this time due to stomach acid and poor absorption.

It appears that the B12 is the first application for this. I guess it will generate some income to support the research for the other uses.

I just hope it is not priced so high as to be out of many peoples' reach. And I couldn't find what type of B12 they are doing either.
I hope it is methylB12.

I think those questions will resolve soon, as it will be out soon.

[sguinn]

I have been diagnosed with mild depression and have been prescribed a low dosage of prozac. My symptoms are not feeling sad, angry, etc but more tired, sluggish, lack of motivation, etc. I have read online that taking B12 could help. Is this something I should do? If so, what kind do I take? I have looked online and there are so many. It looks like some have b-6 and folic acid as well. Thanks in advance for your help.

[mrsD]

Folate has been shown to be low in people with depression.
Same with DHA (a long chain fatty acid found in fish and fish oils).

The newest data also shows low Vit D leads to depression.

Low B12 actually damages nerves, the myelin that insulates them is maintained by B12 and other nutrients. Myelin damage also shows up as numbness/tingling and peripheral nerve pain.

Certainly B12 helps with neurological problems, but it is not the only player in nerve maintenance.

So you would have to pay attention to several things. You can be tested, for Vit D and B12. I'd get that done to see if you need them.

Many people with simple low energy complaints, do well on a simple high potency B-complex. A B-50 type or something similar once a day in the morning often makes people "feel better". That is where I would start. Many people have posted on boards that this brand was very good and useful for them:
http://www.iherb.com/B-Right-100-Capsules/110?at=0

After testing you will see if you need more B12 than this product offers.

[Starglow]

I've had tingling in my hands/feet for almost two months now and my feet started burning on the bottoms about a week ago. I went to the GP doctor and they tested my blood.

Two days later, they called me and said my B12 level was way too high (+2000) and that I should stop taking the B-complex vitamin supplement I was taking.

The burning in my feet is still there, but has decreased somewhat. I've also been exercising every day and doing some lite yoga. My acupuncturist put me on some herbs, so I can't tell at this point if stopping the B-complex vitamin, taking the herbs, exercise, or a combination of the three is helping my feet. The "night tingling" in my hands and feet have also decreased.

My experience and the advice of my doctor seems to contradict what has been presented here regarding high levels of B-12, which has left me a bit confused. I won't see the nero doctor until next month and have no official DX yet, but plan to consult my acupuncturist next week regarding taking the B-complex and my unexplained high levels of B-12 in the blood test results.

I would appreciate any comments/observations/suggestions from the group.

Thanks.....!