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Low B12 in pregnant moms may lead to TypeII diabetes in children

Vitamin B12 deficiency in pregnancy could raise type 2 diabetes risk for children, study finds

This is a Yahoo item and they often are purged so I don't expect a long life on the net for this info.

Quote:

Ensuring pregnant women get enough vitamin B12 could help reduce their children's risk of developing type 2 diabetes. Researchers based in the UK have found that the vitamin -- principally found in meat and fish -- can affect levels of a hormone called leptin, which triggers the "full" feeling after eating, and which can be linked to metabolic conditions such as diabetes. .....
According to researchers at the University of Warwick, the metabolic changes linked to vitamin B12 deficiency could be caused by abnormal levels of leptin, a hormone that tells us when we are full after eating.

The researchers' study showed that babies born to mothers deficient in B12 had higher than normal leptin levels. This suggests that a lack of B12 can adversely program the leptin gene, changing the levels at which the hormone is produced as the fetus grows.

Leptin is produced by the body's fat cells and levels of the hormone rise in the body after eating. In cases of obesity, leptin levels rise and remain constantly higher than normal, which makes certain individuals feel hungry and overeat. This can cause leptin resistance, continued overeating and increased risk of insulin resistance, which leads to type 2 diabetes.

"The nutritional environment provided by the mother can permanently program the baby's health," said Dr Ponusammy Saravanan, senior author of the study. "We know that children born to under or over nourished mothers are at an increased risk of health problems such as type-2 diabetes, and we also see that maternal B12 deficiency may affect fat metabolism and contribute to this risk. This is why we decided to investigate leptin, the fat cell hormone."

Is this Study a Concern? Vitamin B6 and B12 Supplements Appear to Cause Cancer in Men

Quote:

Originally Posted by Joe Duffer (Post 1249653)

Taking B12 Vitamins May Cause Lung Cancer - The Atlantic

Alan and I saw this on TV the other day. Doesn't seem to affect women. But Alan only takes it once a week now. Maybe it has to do with men and testosterone levels?

Ah yes. Thank you for the validation.

When I was here some time back, I was shot down for mentioning this B12 cohort in PN therapy. Remember? I was told "B1 and only B1 all the way, baby." No. I also did my research, as I have no plans of being a cripple. Now everybody and every snake oiler is selling the B12 hypothesis. Haha. No loneliness is there, in being avant garde.

However, B12 will be of limited use, unless it is specifically indicated. I mean, get homocysteine (HCY) level and methylmalonic acid (MMA) levels checked, else false Puck the Phlebotomist is proven to be.

Also, if you are taking high B9, (folate/folic acid) you will mask B12 deficiency - it wont show. BUT you will continue to worsen your condition -- IFF B12 is indicated as a reason for it.

But, please allow me to post about my recent findings elsewhere, for the good of whoever may benefit.

Hi Mrs D. I was just looking into Methycobal as it was suggested by a friend. It is produced by the Eisai Co in Japan and quite expensive. The same company is listed on the research. https://www1.ndmctsgh.edu.tw/pharm/p.../005MET29E.pdf

Quote:

Originally Posted by mrsD (Post 909580)

That is really interesting! Thanks, Marlene, for putting it up here.

It appears to be a rare finding, but all information pertaining to B12 is important for us. Many people end up on the net because of some rare issue, that doctors are missing in their diagnostic work ups.

I wonder what the treatment mentioned is...? Maybe just higher doses of the supplement?

I think the genetic information coming out on the human genome will show other genetic errors with other nutrients.
The MTHFR mutations are other examples.

I recall Dr. Bruce Ames PhD stating in a paper on PubMed from years ago that he believes there are genetic errors involving many B vitamins in people, resulting in illness.

I don't see any benefit for the brand you are posting about compared to others available for purchase. Their highest oral dose is 500mcg.... which is rather low for an oral form.

Orally 1000mcg is much better. Very little is absorbed orally so a large dose is necessary to deliver a very small amount.

PubMed Central, Table 1: Blood. 28 Sep 15; 112(6): 2214–2221. Prepublished online 28 Jul 7. doi: 1.1182/blood-28-3-4253

The above link is from a paper (the whole paper link is in the first post in the B12 information thread here)
It compares various oral forms of cobalamin treatments showing that only 13micrograms is bioavailable from an oral dose of 1000micrograms (1 milligram).

I bought the Puritan's new 5mg methylcobalamin several years ago to test it. I had a first test several years before to see if I needed it and tested at 875 at that time. I took the methyl 5mg once a day on an empty stomach for 3 months and then got a retest.
It came back as 1998 which was the maximum of that test range at the lab my doctor uses. My doctor was very surprised..she did not know this! So now that I am in my 70's I use the methylb12
once a week or so. Puritan's is not a flashy company so people assume it is so so. I've also purchased methyl 12 from Costco and the tablets seem identical (no imprint and chewable) I don't think there are alot of companies providing these tablets, I think just one or two who provide the generic form for others to buy and distribute.

I've been taking Methyl B-12 for years. It kicked my neuropathy to the curb and made me have the memory of an elephant. However, because of the latest reports of how it affects men, my husband stopped taking it.

Don't know what to make of this.

Melody

Hi, there first time on this site. I want to thank you for posting info on B12. My Neur doctor just prescribed that to me today. I go for more testing. Everything I have read and after talking to the doc it is looking like TBI

Quote:

Originally Posted by Sicabre (Post 1265068)

What is TBI?

TBI = Traumatic Brain Injury
We have a forum for TBI here https://www.neurotalk.org/forum92/