[julleri]

The reactions are hard to explain. I got too much energy and felt crazy. I couldn't think and my thoughts were all over the place. My stomach got upset and I got a lot of gas. I had to frequently urinate and the urine smelled awful and was a funny color. I felt terrible. My therapist whom I told said it was the xylitol. She says she's seen others react kinda similar, feeling crazy, etc.

I just need a little bit of daily intake of B12, but I do not want to "feel" the vitamin, if that makes sense. The shots are up and down, which is awful. I take other vitamins (ironically enough, a multivitamin that contains only 18 mcg of B12, which I am obviously not absorbing). I don't "feel" those vitamins at all. So, I dunno. Would I be able to "not feel" a B12 oral that I swallow, the non-sublingual kind, do you think?

Thank you

[mrsD]

Originally Posted by julleri

The reactions are hard to explain. I got too much energy and felt crazy. I couldn't think and my thoughts were all over the place. My stomach got upset and I got a lot of gas. I had to frequently urinate and the urine smelled awful and was a funny color. I felt terrible. My therapist whom I told said it was the xylitol. She says she's seen others react kinda similar, feeling crazy, etc.

I just need a little bit of daily intake of B12, but I do not want to "feel" the vitamin, if that makes sense. The shots are up and down, which is awful. I take other vitamins (ironically enough, a multivitamin that contains only 18 mcg of B12, which I am obviously not absorbing). I don't "feel" those vitamins at all. So, I dunno. Would I be able to "not feel" a B12 oral that I swallow, the non-sublingual kind, do you think?

Thank you

I think you should swallow the B12... most of it is not absorbed.
It is not really believed that B12 is well absorbed sublingually, as the molecule is really huge and the area under the tongue is so small.
The studies comparing oral B12 to injectable, measured serum levels, and response to swallowing oral, and they both compared over time with improvements.

There are people who have "chemical sensitivities" and react to many things. Chemical sensitivities are not well understood, however.
B12 is so small a dose, it is not going to be obvious in the urine.
Other B's however, do cause color changes, and B1, will impart an odor which some call "yeasty". B2 and B6 typically cause a yellowish or light greenish cast in the urine about 2-4 hours after taking.

People reacting so quickly, may have a genetic issue with methylation. Folic acid is affected by this too. Folic is synthetic like cyano is synthetic, and so there is an active form for it available now for the genetic people who cannot make activated forms of both vitamins B12 and folic acid. It is called methylfolate and is OTC. Solgar makes it.

There is a theory that methylation issues contribute to some mental issues. Rapidly thinking thoughts, is a hypomanic state, and bipolar disorder is thought to be a methylation disorder. The drugs used to treat it block methylation of DNA.
The Pfeiffer institute has a site to explain this:
You can read this paper by Dr. Walsh and discuss with your doctor/therapist:
http://www.alternativementalhealth.c...s/pfeiffer.htm

It is possible you are triggering something that you normally do not feel, with the B12.

Certainly for people very low for very long times, there is an adjustment when the B12 is first given. But this varies from person to person. There are other forms of B12 that are slower in onset than methyl. You can try one of these to compare:
This one is recommended for those to are over reactive to the methyl form:
http://www.iherb.com/product-reviews...lets/2454/?p=1

[julleri]

Thank you for all your help.

It is amazing how up and down I feel. Yesterday morning I felt "anemic." I had a hard time breathing, had absolutely no appetite, felt dizzy, could not think, etc. Sometime around 3:00 in the afternoon I felt yesterday morning's shot of cyanocobalamin kick in (apparently by body can methylate it well) and I felt better. Not great, but better. I had a bad evening again, where I felt a lot of pain and felt horribly depressed and confused. Today, I felt more "stable" and "even." I felt pretty good. I looked in my sharps container and I've given myself 8 injections so far. Is it normal in the beginning of this to go between a good day and a bad day so rapidly like this? I am afraid of going only once a week. My therapist recommended that I keep taking the shots every other day for this week and calling my doctor if I need more shots and ask him to continue every other day if I have to. But this can't be normal, right? No one takes these shots every day or every other day on a normal basis.

I found a B12 pill that is not a sublingual that I am willing to give a try. It is a capsule form, and is only 500mcg. The only other ingredients in this (besides the caynocobalamin) are rice flour, gelatin, and beet powder. I don't think I should "react" to any of these. I know it's only 500, but I could not find any 1000 mcg or higher that didn't have any sugar alcohols in them. Would it be OK, if I try this 500 and don't negatively react to it, to take two 500's and get the diffusion effect? Is it OK that it's a capsule?

I read that it takes about 20 injections to fully reload the liver of it's depleted B12 stores. Will these up and downs finally even out at about that time? Also, since B12 is stored in the liver, could it be that I have a liver function problem? I see B12 deficiency is really only caused by diet or absorption issues, but do you know if there are any B12 deficiency caused by liver problems known?

I also voiced my concerns over the high boost of energy I get from the methylcobalamin form to my therapist, and she suggested I try maybe 500mcg shots instead of the full 1000. Any ideas on this?

This B12 issue is so complex. I wish it were just as easy as take a tablet everyday, feel better. It really doesn't help that I'm also in the thick of antidepressant withdrawal and maybe other health issues as well.

Thank you,
Jason

[mrsD]

There won't be a problem with the B12.... you may need two of them, and take on an empty stomach.

However, if you have the polymorphism, the MTHFR error, you won't be able to activate cyano form and it won't work.

If you are anemic you may be making red blood cells very quickly and this depletes POTASSIUM. Low potassium can make you weak and shakey. So massive dosing to methylB12 should be accompanied by potassium rich foods. If you take diuretic drugs for other reasons, you could be very low in potassium. Also magnesium.

[julleri]

Originally Posted by mrsD

There won't be a problem with the B12.... you may need two of them, and take on an empty stomach.

However, if you have the polymorphism, the MTHFR error, you won't be able to activate cyano form and it won't work.

If you are anemic you may be making red blood cells very quickly and this depletes POTASSIUM. Low potassium can make you weak and shakey. So massive dosing to methylB12 should be accompanied by potassium rich foods. If you take diuretic drugs for other reasons, you could be very low in potassium. Also magnesium.

Thank you

I tried to post a reply but for some reason it didn't get posted.

Supposing I don't have the genetic error (what is this by the way?) then I would be able to convert the cyanocobalamin for my body to use, right? I didn't react to it, so I should probably be OK to take 2 capsules a day, correct?

Tomorrow morning I plan to take 500mcg of methylcobalamin shot. Would it be OK to take the cyano capsules as well?

I still really don't feel very well. Completely up and down. One day I can feel OK, the next day I could feel like I'm dying again. Is this normal in the beginning?

What again is this genetic error and would there be any other indicators that I'd have it?

Thank you

[mrsD]

I wish I could tell you what to do....but we are not doctors here.

Seems to me if you inject MethylB12 you don't need oral cyano.

Anything further I think you should seek out a physician who can
test you out to see if your B12 is working. The test is called MMA.

This will answer your question hopefully. If the MMA is elevated, that would be a bad sign, and point to further testing to see if
you have the MTHFR mutation, which is a DNA test.

Without answers to specific tests, no one will know what is really going on with you.

[julleri]

Originally Posted by mrsD

I wish I could tell you what to do....but we are not doctors here.

Seems to me if you inject MethylB12 you don't need oral cyano.

Anything further I think you should seek out a physician who can
test you out to see if your B12 is working. The test is called MMA.

This will answer your question hopefully. If the MMA is elevated, that would be a bad sign, and point to further testing to see if
you have the MTHFR mutation, which is a DNA test.

Without answers to specific tests, no one will know what is really going on with you.

I understand you are not doctors. I've already learned a lot from you. Thank you so much.

I have an appointment with a gastro-enterologist on May 1. I also submit a request to be contacted by a doctor at a neurological center close by.

I will continue the methylcobalamin B12 shots and hopefully will feel better soon. I have to realize that I didn't get this overnight, so it might take a long time before I feel things getting better. The trouble is, that after the shots, I ALWAYS feel better, just depends on the number of hours after the shot depending on the type of B12. I just hate the feeling when it wears off and I feel very sick again. Just was wondering if that was normal, especially within the first few weeks of treatment for low B12.