[mrsD]

Originally Posted by Marlene

http://www.sciencedaily.com/releases...0827074146.htm

That is really interesting! Thanks, Marlene, for putting it up here.

It appears to be a rare finding, but all information pertaining to B12 is important for us. Many people end up on the net because of some rare issue, that doctors are missing in their diagnostic work ups.

I wonder what the treatment mentioned is...? Maybe just higher doses of the supplement?

I think the genetic information coming out on the human genome will show other genetic errors with other nutrients.
The MTHFR mutations are other examples.

I recall Dr. Bruce Ames PhD stating in a paper on PubMed from years ago that he believes there are genetic errors involving many B vitamins in people, resulting in illness.

[Marlene]

I too was wondering how you treat this. It seems that you never really see any follow up on these articles. At least we are now aware of these types of problems.

BTW....welcome back from vacation.

[julleri]

... Puritan's Pride is having another buy 1 get 2 free sale...

Sale lasts through September 25.

[MelodyL]

Originally Posted by julleri

... Puritan's Pride is having another buy 1 get 2 free sale...

Sale lasts through September 25.

And we bought our vitamins last night. Great deals.

Melody

[julleri]

Originally Posted by MelodyL

And we bought our vitamins last night. Great deals.

Melody

Oh no! Did you get them from a store? Have the receipt? Sometimes returns are a hassle, but with how expensive vitamins and supplements can be.... might be worth the trouble.

[mrsD]

This is unusual for Puritan's... usually that sale, which is the best one for savings is only in the spring and early summer.

I get a few things from them, and might get more biotin since I gave my son some of my extras.

Thanks for the reminder.

[pinkynose]

Hi Mrs D. I was just looking into Methycobal as it was suggested by a friend. It is produced by the Eisai Co in Japan and quite expensive. The same company is listed on the research. https://www1.ndmctsgh.edu.tw/pharm/p.../005MET29E.pdf

Originally Posted by mrsD

That is really interesting! Thanks, Marlene, for putting it up here.

It appears to be a rare finding, but all information pertaining to B12 is important for us. Many people end up on the net because of some rare issue, that doctors are missing in their diagnostic work ups.

I wonder what the treatment mentioned is...? Maybe just higher doses of the supplement?

I think the genetic information coming out on the human genome will show other genetic errors with other nutrients.
The MTHFR mutations are other examples.

I recall Dr. Bruce Ames PhD stating in a paper on PubMed from years ago that he believes there are genetic errors involving many B vitamins in people, resulting in illness.

[mrsD]

I don't see any benefit for the brand you are posting about compared to others available for purchase. Their highest oral dose is 500mcg.... which is rather low for an oral form.

Orally 1000mcg is much better. Very little is absorbed orally so a large dose is necessary to deliver a very small amount.

PubMed Central, Table 1: Blood. 28 Sep 15; 112(6): 2214–2221. Prepublished online 28 Jul 7. doi: 1.1182/blood-28-3-4253

The above link is from a paper (the whole paper link is in the first post in the B12 information thread here)
It compares various oral forms of cobalamin treatments showing that only 13micrograms is bioavailable from an oral dose of 1000micrograms (1 milligram).

I bought the Puritan's new 5mg methylcobalamin several years ago to test it. I had a first test several years before to see if I needed it and tested at 875 at that time. I took the methyl 5mg once a day on an empty stomach for 3 months and then got a retest.
It came back as 1998 which was the maximum of that test range at the lab my doctor uses. My doctor was very surprised..she did not know this! So now that I am in my 70's I use the methylb12
once a week or so. Puritan's is not a flashy company so people assume it is so so. I've also purchased methyl 12 from Costco and the tablets seem identical (no imprint and chewable) I don't think there are alot of companies providing these tablets, I think just one or two who provide the generic form for others to buy and distribute.

[MelodyL]

I've been taking Methyl B-12 for years. It kicked my neuropathy to the curb and made me have the memory of an elephant. However, because of the latest reports of how it affects men, my husband stopped taking it.

Don't know what to make of this.

Melody