I have been taking the starter pack for the Savella now for 2 weeks.The only complaint I have is extra fatigue that occurs about 5hrs after each dose.I have tried Lyrica which in high doses is successful that is if you dont mind being swollen like an individual past due for their dialysis.Cymbalta never did anyhting but make my heart race.The Savella I do believe is helping because I am not feeling the weather like I normaly do and my arthritis or whatever it is in my hip has been behaving itself alot better.God I do hope this is help for those who are suffering.It would be nice to have something work besides those narcotics.If you can it is worth a shot, it has helped my symptoms Iwould say by about 35-40% and I dont think it is just coincidence.