SUPPLEMENTS~ for Peripheral Neuropathy:

MzBeanz · 02-03-2012, 02:54 PM

Thank you! What about the B's how much of those? and when should I take the D?

mrsD · 02-03-2012, 03:18 PM

There is B6 in the Metanx. So you really don't need high dose
B complex. A good multivit...or "stresstab" type should do.

This is one moderate doses B-complex.
http://www.jarrow.com/product.php?prodid=57
If you choose the B-Right... take your aspirin 1 hr before this combo,
since it has a small amount of niacin 25mg in it. This is a very small amount compared to the Niaspan... so it won't matter much.

Or you could just do Centrum. I don't think you need higher because of the Metanx.

You can take the D anytime. If oil type caps, with food is okay.

Nabilejlm · 02-03-2012, 05:10 PM

Quote:

Originally Posted by mrsD

Most vitamins can be taken with food.

Exceptions.

1) Separate B12 oral should be on an empty stomach.

2) Lipoic acid is absorbed better on an empty stomach.

3) acetyl carnitine is best broken up into several doses and not taken all at once in one large dose.

4) Products in oils, are best taken with goof.

5) calcium supplements are best taken in divided doses too.

I think you should get tested for Vit D and B12 to see where you are presently. This would then point to how much you need if you really need them. Zinc can be tested for too.
Zinc is unlikely to be low unless you take ACE inhibitors for blood pressure, or daily acid blocking drugs. Prednisone and birth control pills may lower zinc levels too. People eating meat, and seafood, do not get low in zinc as a rule.

Choice of which supplements to start on and concentrate on depend on your medical history. What is causing your PN?
Trauma/injury? at a young age? Type I diabetes? Hereditary? Supplements may not work on hereditary patients. Heavy use of therapeutic agents that damage nerves...chemo and other drugs? Lupus?

If you have a basic nutrient deficient PN from low B12, the other supplements are less important, than fixing the B12 first.
If you add too many together in the beginning you cannot see which of them are working and which are not.
Since magnesium is needed and commonly low, taking a good
product (not OXIDE type), at 1/2 the RDA is helpful. Many people in US are low in magnesium...not just diabetics and PNers.

The B-complex, C, and magnesium are useful for many people other than PNers. It all depends on what your diet is like, and your medical history, and drugs being taken, OTC and RX.

I was confused wether this answer was for me? If so I will try to get tested I began my neuropathy years ago but the tingling just started I don't take any meds either... How much lipoic acid and acetyl carnite should I takedaily?

mrsD · 02-03-2012, 05:21 PM

This answer is generic...for everyone.

If you choose the R-lipoic stabilized, 100mg a day to start is
a good dose. You can raise it later if you tolerate it. Some of us
find it too stimulating in higher doses. This new form is so much more absorbed than the older forms, 100mg is a good dose for most people.

The acetyl carnitine would be 500mg a day to start, and work up to 2 grams a day divided doses, if necessary.

These are for mostly mitochondrial damage. If your PN is not of this type, they may not work. The lipoic acid will also improve glucose utilization, and provide some antioxidant effects. It is more globally acting than the carnitine. The acetyl carnitine has been used for chemo drug damage and HIV drug damage.
Both cause toxic neuropathies.

Nervous · 02-04-2012, 12:15 PM

I believe that it was in this thread that someone said they were taking 600 mg of benfotiamine. I'd be grateful for guidance and opinions regarding dose size for benfotiamine. I'm taking 300 mg now.

Sallysblooms · 02-12-2012, 04:53 PM

I take 250mg of the Mega Benfotiamine by Life Extension. It was added to my ALA and other supplements a couple of months ago. The rate of nerve healing went way up. My feet are almost healed now.

My Autonomic neuropathy was only noticed in my feet as far as what I could feel but with my POTS, it is all over of course. My OI (POTS) is so much better now also. It is very exciting. I am thankful for supplements that heal.

mrsD · 02-12-2012, 05:33 PM

I just added this study to my Benfotiamine link:

Quote:

Int J Clin Pharmacol Ther. 1996 Feb;34(2):47-50.
Pharmacokinetics of thiamine derivatives especially of benfotiamine.
Loew D.
Source

Wuppertal, Germany.
Abstract

Pharmacokinetic data of orally administered lipid-soluble thiamine analogues like benfotiamine are reviewed and assessed. It is quite clear that benfotiamine is absorbed much more better than water-soluble thiamine salts: maximum plasma levels of thiamine are about 5 times higher after benfotiamine, the bioavailability is at maximum about 3.6 times as high as that of thiamine hydrochloride and better than other lipophilic thiamine derivates. The physiological activity (alphaETK) increased only after benfotiamine was given. Due to its excellent pharmacokinetic profile benfotiamine should be preferred in treatment of relevant indications.

PMID:
8929745
[PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

This fat soluble form of Thiamine is far better absorbed than regular Thiamine. The old dose of thiamine for PN was 300mg a day or less. This is before gabapentin hit the shelves!

Because it is so much more absorbed, and because it stays around LONGER...not excreted so quickly... I have qualms about such high doses. I searched PubMed recently and there are no papers to speak of for this nutrient on dosing. I found ONE paper for cardiac damage indicating 400mg a day in a small subset of patients. I found only 2 pgs on PubMed, and those were mostly in animals, and from other countries.

So I will remind people here, that the high 600mg or more dose a day... comes from sites that sell this. For that reason, I personally cannot endorse it at those levels or beyond.

But since this is OTC...you can do what you choose, based on what you learn about it. If you decide to do this very high dose, just be very vigilant. It may be that only weeks are needed for this way. There is no evidence that really LONG term use, is safe yet, or that effective for most people.

I, myself, take 150mg a day. This keeps me from severe burning.
I also drink moderately 2 or 3 times a week, depending.

Nervous · 02-12-2012, 08:08 PM

Quote:

Originally Posted by Sallysblooms

I take 250mg of the Mega Benfotiamine by Life Extension. It was added to my ALA and other supplements a couple of months ago. The rate of nerve healing went way up. My feet are almost healed now.

My Autonomic neuropathy was only noticed in my feet as far as what I could feel but with my POTS, it is all over of course. My OI (POTS) is so much better now also. It is very exciting. I am thankful for supplements that heal.

That's remarkable. I am so happy for you that you got such a good result!

And thanks for sharing this info!

Sallysblooms · 02-13-2012, 12:36 AM

Thank you. When I said all over, the Autonomic Neuropathy affects the blood vessels (OI) heart etc, but the place I can feel it is my feet. I responded great to all of my supplements, but the ALA and especially the have been healing for me.

Idiopathic PN · 03-11-2012, 08:34 PM

Quote:

Originally Posted by plgerrard

This site has some good information on Vitamin D for both patients and doctors.

Pain Treatment Topics

The Patient Brochure and Practitioner Briefing at first appear to be written for musculoskeletal pain, but both also report an improvement in neuropathic pain. The Practitioner Briefing mentions this study:

The Full Report states the the pain levels (from trial) improved from 'distressing' to 'mild'.

.

Is there a VIt D overdose? I am supposed to take a 1200mg of calcium a day. But since I am taking gabapentin 3x a day, I could not follow now the 3x a day dosage of calcium ( (less window of squeezing in between gabapentin without compromising absorption) . Instead I only take calcium 1x a day. To help in the absorption of the calcium I take vitd3
2000IU.

Thank you for time.

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