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Methylfolate and folic acid together

I have read that it is bad to take methylfolate and folic acid together, especially if you have the MTHFR mutation. Something about the unmethylated folic acid blocking the pathways that the methylfolate needs to use.)

Is this true? And - if so, do you know of a basic multi-vitamin that does not contain folic acid? (I have found a few, but they are either extremely expensive, and/or are the "six capsules a day" mega supplements.)

There has been some published papers suggesting that folic acid may compete for methylfolate at the blood brain barrier.

I haven't read anything recently however.... but from what I read not too long ago, this was not 100% proven.

It is a problem because folic acid is supplemented in many US foods now. If true, then there has to be some way to minimize the folic acid contribution. So it is not just the multivitamins that would be worth looking at (in the US).

I'll look into this or you can as well... My first stop will be MTHFR.net. If anyone has an answer, he will.

Thanks for the suggestion - I checked the MTHFR website, and couldn't find a specific explanation for "why". But, the first three things in Dr. Lynch's "protocol" for treating the MTHFR mutation are:

1. Avoid fortified foods with folic acid
2. Avoid supplements with folic acid
3. Avoid folic acid blocking drugs

Seems pretty clear that he doesn't feel folic acid is a good thing if you have the MTHFR mutation.

Quote:

Originally Posted by Ragtop262 (Post 1140802)

Is this true? And - if so, do you know of a basic multi-vitamin that does not contain folic acid? (I have found a few, but they are either extremely expensive, and/or are the "six capsules a day" mega supplements.)

I went through this process awhile back, and found this one. I haven't gotten it yet, as I want to spend a little more time looking into everything in it (second link).

http://www.amazon.com/gp/product/B00...A2UISRVENUHQL4

https://www.pureencapsulations.com/m...eNutrients.pdf

Quote:

Originally Posted by janieg (Post 1141520)

Interesting. As it happens, I'm considering switching from my current multi-vitamin, but I have not found a new one yet. I'll give this a look. Thanks. :)

Quote:

Originally Posted by janieg (Post 1141520)

Thanks Janieg - I'll check into this one, looks like it might be what I was looking for.

Quote:

Originally Posted by mrsD (Post 1140575)

Yes, I do think this is really important. When we first started here on NT... the DNA testing was not really easily available.

But I have watched over the years, and all the posts, where people gravitate here because all other venues have failed in some way.

Now after 2 years we've had some posters do the 23andme testing and all of them come back with mutations. The old % suggested by Merck when the research first came out was 10% have this. Then a doctor came on our General board and stated that he specializes in this, and went to a new seminar and they were raising the % to 30 (and perhaps even more).... so it does seem that methylation errors are becoming very significant.

The testing will also show COMT errors...which are also important.

If a person has only one chromosome affected, they limp along until they reach a state where they cannot function anymore.
The patients who have the double mutation (homozygous), are affected at earlier ages, it seems.

So yes, I think getting the testing may be helpful for you.

Well, I purchased the 23 and Me testing, and the kit arrived Friday. I'll see what the results are in several weeks.

BTW, I have a sister who had the 23 and Me testing done a while back, primarily for ancestry purposes. After talking about this with her, she ran her results through Genetic Genie - and she found that she is heterozygous for the MTFHR 1298 gene, and several of the COMT genes - but normal for the MTFHR 677 gene. It will be interesting to see what my results say.

Quote:

Originally Posted by Ragtop262 (Post 1144206)

I'm on 23andme. We can see if we're related. :winky:

This link is pretty good... distills down some of the lingo...

http://doccarnahan.blogspot.com/2013...-big-deal.html

Excellent link to have. thanks :)