OK, I got my results back, and ran them through Genetic genie. Turns out I'm normal for the 677 gene, but homozygous for the 1298 gene, as well as a few of the other methylation genes.

Any help on where I can get advice on how to best deal with the specific set of mutations I have?

On the website www.livewello.com, you can upload your results, and they'll provide you a nicely formatted version of around 250 SNP results. I think the cost is $20. You would then have a link to your formatted results (or hard copy print-out) you could provide to a practitioner...if you wanted to go that route. There's also a list of practitioners on their site who would do consultations based on those results. I haven't done that yet.

One thing I learned in trying to make sense of my results is that they're all intertwined, and you have to understand how they all interrelate before knowing what needs to be done. I wasn't able to figure out how to make sense of them as a whole. I'm ok on 677T, but heterozygous on 1298C. Since the latter apparently isn't as critical as being compound heterozygous, or having 677 issues, I haven't been frantic about learning about. Still, I could have issues I need to address.

Before I would do a consultation with anyone, I would get recommendations from people who have already worked with them, and there are nice forums on Livewello where you could probably do that. I'm sure there are other free sites as well.

The integrative doc I went to asked for my methylation results, then really didn't know what to do with them. I was impressed.

What's your Norovirus Resistance trait? That's FUT2 which can have some pretty significant impacts on your health that they still don't fully understand.

I thought finding the methylation issue would lead me to some way of helping myself. But the deeper I dig the more complex it becomes, and the more apparent it is that this is too new and nobody really knows what the right thing to do is.

For now, I think I'll bump up my methyl folate dosage a bit more as well as working harder to avoid synthetic folic acid as much as possible.

I'll keep researching this thing, and hopefully I'll figure it out eventually. Then again, who knows if this even has anything to do with my PN symptoms.......

I've collected a lot of links in the past year, and there was one in particular that showed a very good diagram of the methylation process and the effect the individual SNPs had on them. If I can find it, I'll post it.

Hi everyone, I haven't posted in awhile but I've been reading everyone's post off and on. My rheumo told me to start 5 HTP with thiamine and cayenne pepper tablets. He said he has been using both and it is helping him with joint pain. I did buy them today and then realized I probably should have checked them out first.
Do any of you take these? Do they help?
I currently take fish oil, D3, probiotics, Curcumin, B12 every other day and COQ10 for supplements. I use to take R lipoic acid but read that it really works for those with diabetes.
I'd appreciate any information you can give me. Thanks!

I take 5 HTP and thiamine. Not sure how much it helps. Things haven't really been getting any better, but they haven't gotten much worse either. However, things were getting worse fairly quickly before I started taking the supplements - so maybe they are helping

What dosage of 5 HTP do you take?

My apology - I am not taking 5 HTP (I am actually taking P-5-P - 50 mg/day). I'm taking so many things lately, I get confused sometimes

LOL! No problem...I can relate.

I have my annual physical next month, and my PCP always wants to know what supplements I'm taking. I'm going to have to make a list and make sure I can I intelligently state why I'm taking each one. I look at the bottles here, and there's at least one that I'm not quite sure why I take.

Any thoughts on Acetyl L-Carnitine as a supplement for neuropathy at this point? I've read some older discussions of it here.

Is 1000 mg the recommended dosage? Or 500 mg twice a day?

It's one of the supplements I haven't tried.

http://care.diabetesjournals.org/content/28/1/89.full


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