Hi All,

I have suspected PN for the last two months or so. Symptoms are not severe, but occur on a regular basis in the evenings/nighttime(tingling, pins and needles, sharp random shooting pains).

Brief medical history. I have hypothyroidism and taking 0.05 levothyroxine for the last 5-6 years.

In 2016 was diagnoted with gout and take 200mg allopurinol daily for hyperurecimia. Can allopurinol cause neuropathy? I saw some google articles on it.

I am taking the folowing supplements on a daily basis
1) R - Alpha Lipoic Acid (600mg/day)
2) Dr's Best Benfotiamine (600mg/day)
3) Milk Thistle (500mg/day)
4) Methyl B12 (1000 mcg/day)
5) Curcumin (500mg/day)

Anything to add to the list/subtract from the list?

PS : Since levothyroxine interferes with other meds /vitamin , particulalrly R-ALA , i take it four hours before/after any other vits /meds.


Thanks and much appreciated

Hi,

You might try fish oil:

Frontiers | Long-Chain Omega-3 Fatty Acids Supplementation Accelerates Nerve Regeneration and Prevents Neuropathic Pain Behavior in Mice | Pharmacology

You will might also be interested in reading the thread on Resveratrol in the main forum for PN.

https://www.neurotalk.org/peripheral...sveratrol.html

I have been taking both fish oil and resveratrol for three months, unfortunately to no noticeable effect.

Omega 3
 

Thanks ..


fish oil is obviously good because of its high omega 3 content. Does Omega 3 fortified eggs also server the same purpose, as I am allergic to certain kinds of fish?

Oily fish like salmon, sardines, mackerel and herrings are all rich in omega-3 fatty acids.

newbie dosage question
 

Hi Folks

I have Suspected PN for about a couple of months. I have a neurologist appointment next month. Meanwhile , I am combating my neuropathy with the following supplements:

R- Alpha Lipoic Acid (300mg X 2 times daily)
Benfotiamine B1 (300mg x 2 times a day)
Methylcobalamine B12 (1000mcg daily)

I also take the following prescription meds : allopurinol 200mg/daily for gout/uric acid and levothyroxine 0.05 mg for hypothyroidism.

To this I have added acetyl l-carnitine (1000mg/daily) to the mix. The symptoms seem to have improved a little bit lately, but I am concerned about my dosing and possible interaction between levothyroxine and acetyl l-carnitine.

Any comments /advise please??

Thanks

What about acetyl l-carnitine? I tried it for a couple of days , but gave me really bad insomnia, so I discontinued it. Plus it interacts with the levothyroxine I am taking. I read somewhere that R-ALA is not as effective without acetyl l-carnitinie. Is that true?

This is complicated.

Some clinical trials suggest that acetyl-L-carnitine as a supplement can help in management of neuropathic pain (Acetyl-L-carnitine in painful peripheral neuropathy: a systematic review).

I can't think of any reason why the effectiveness of R-ALA taken as a supplement should depend on the availability of acetyl-L-carnitine.

l-Methylfolate
 

Thanks Kiwi

I have made the following changes to my regime: removed curcumin and milk thistle, added Omega 3 (1200g) and Acetyl L- Carnitine .


I also heard about L-Methylfolate . Any inputs on that ? What is the recommended dosage? I read from some of Mrs D's old posts that high doses of L-Methylfolate are linked to colon cancer risk.


1) R - Alpha Lipoic Acid (600mg/day)
2) Dr's Best Benfotiamine (600mg/day)
3) Omega 3 fish oil (1200mg/day)
4) Methyl B12 (1000 mcg/day)
5) Acetyl L- Carnitine (1000mg/day)

I'm not sure if anyone has posted about the role of nose breathing as an aid to treatment before. I appreciate this is not technically a supplement but I believe this is worth looking at. This is a quote from an article.....

Nose breathing drives oxygen more efficiently into the lower lobes of the lungs rather than staying in the upper lobes, as with mouth breathing. With nose breathing, all five lobes of the lungs are used to breathe rather than just the upper two. The lower lobes of the lungs have more parasympathetic, calming and repairing nerve receptors, which are activated during nose breathing exercise. The upper lobes have more sympathetic (fight or flight) stress receptors that are activated during mouth breathing exercise.

There are countless videos and articles promoting the benefits of nose breathing, especially while sleeping.

My thoughts are that if we can boost our oxygen supply to our periphery then that goes a long way to towards healing. And by boosting parasympathetic nerves we can only help ourselves. One doctor describes how cold hands become warm.

I've tried to train myself to breathe through my nose especially on my lock down walks and done lots of breathing exercises, (again countless links). There appears to be a lot of evidence supporting benefits. I am looking to see if my cold hands become warm.

I agree on the deep nose slow breathing, breath in long thru the nose, and breath out long and slow thru the mouth. I do this daily and learned about it when in rehabs for months with knee infection......I do about 10 times or so and again later in the day. The PT people were always preaching Breathing...and one taught me the above method.

I've talked about Inosine and Sphingolin for the neuropathy I deal with and these have helped me.