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05-06-2015, 04:21 PM | #1 | ||
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Thanks Mrs. D for the quick response. I'll give the extra methylfolate a shot and see what happens. I've also been considering getting the testing done for the MTHFR mutation - this might be a signal that I should go ahead and spend the hundred bucks. (Small potatoes compared to all the deductibles and copays I've paid for all the other tests and appointments over the past several months........) |
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"Thanks for this!" says: | mrsD (05-06-2015), Patrick Winter (08-23-2015) |
10-15-2015, 08:37 PM | #2 | ||
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Thanks, Cliffman |
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"Thanks for this!" says: | Nervous (10-15-2015) |
10-16-2015, 07:33 AM | #3 | ||
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Junior Member
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I supplement this daily with another Yarrow complex named B-Right, maybe due to my "old school" belief that larger doses of a single B, prove ultimately more effective when taken in concert with a good B complex. Both are available through Amazon.com or other online venues that fellow members would be more than happy to suggest. Wishing continued turn-around good luck. |
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"Thanks for this!" says: | Nervous (10-16-2015) |
10-16-2015, 08:16 AM | #4 | |||
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Wisest Elder Ever
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If you are set on injectable methylcobalamin... you have to get that at a compounding pharmacy if you want them loaded into syringes. Once loaded, into syringes it requires refrigeration and the typical shelf life is 30 days.
The typical injectable B12 is cyano form and not the activated one. 10-30% have the MTHFR mutation and cannot methylate cyano and folic acid (in supplements) properly. The newest studies show that oral will work, as well with less invasiveness, better results if using the methyl form and taking it on an empty stomach. If you are somehow set on injectable, good luck to you. Most posters here complain about the injectable type of cyano. Stop all supplements about a week before any retesting. Whatever is causing your lower numbers, is not likely going to evaporate. Most people require supplements for life, therefore.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei ************************************ . Weezie looking at petunias 8.25.2017 **************************** These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
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"Thanks for this!" says: | Nervous (10-16-2015) |
10-16-2015, 08:49 AM | #5 | ||
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The only evidence I have read about was in the book "could it be VitB12"? They claim the shots are needed if one has neuropathy issues. That said, I have no idea if it's really true. Cliffman |
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10-16-2015, 10:08 AM | #6 | |||
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Wisest Elder Ever
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Sarge, the company you are describing is JARROW (not Yarrow).
It is one of the first who offered oral methylcobalamin and at one time was only available on iherb.com Today we have other suppliers which are at Puritan's Pride, Costco and Walgreens and perhaps other local places. In the old days, over a decade ago we were only able to get it online. I tested out the Puritan's myself, and at 5mg a day reached a blood level of 1999 (the top of the calibration range). And as I mentioned before, if the MTHFR mutation is present, then one needs the methylfolate also. We are rather fortunate that in some ways repairing B12 levels is fairly simple, now, and inexpensive. Information changes, new studies come out, and like most medical things, are not cast in stone. Still doctors may cling to their old therapeutic manuals, which were printed before 2003. The AAFP link I provide gives new medical information targeting doctors, in 2003 and still people cling to the "old ways". I personally think once a month shots are artificial. We evolved getting our B12 orally from food. When that fails (due to low acid in the stomach or damaged intrinsic factor), then high dose oral is the next best thing IMO. A study I provided earlier shows that 1000mcg oral yields about 13mcg absorbed into the blood.(the remainder is excreted in the stool. This is about 2.5 times the RDA. Injectables only last in the blood for 72 hours, and the excess is excreted, since only minute micrograms can be handled at a time by the systems in the tissues. The same study showed 145mcg in the blood following an injection of 1000mcg. So people getting injections do not all get lasting benefits that way. If you read the whole B12 thread you will find those people who didn't do well on injectable ALONE. Quote:
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei ************************************ . Weezie looking at petunias 8.25.2017 **************************** These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
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10-16-2015, 10:14 AM | #7 | |||
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Wisest Elder Ever
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The book "Could it be B12" came out originally in 2005.
There is a second ed. in 2011, but I don't see mention of updated material, just a reprinting. It is possible the newer edition has newer information. This youtube I believe is from the book you have, but I am not positive: https://www.youtube.com/watch?v=BvEizypoyO0 It is not complete however, and does not get into MTHFR mutations or much of the methylB12 information.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei ************************************ . Weezie looking at petunias 8.25.2017 **************************** These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
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10-16-2015, 06:18 PM | #8 | ||
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Junior Member
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mrsD, thanks much for the correction, as well as the additional venues for purchase. It appears my heart was in the right place, while my head was in some other location--especially since the proper name spelling is plainly and prominently on a written list not 8 inches from my left elbow while at my keyboard. Apologies to all for the careless misinformation and now obvious omissions--can't get away with blaming this one on my PN. Last edited by Sarge; 10-16-2015 at 06:42 PM. Reason: Addition |
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10-17-2010, 08:45 AM | #9 | ||
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I've recently been diagnosed with sensory motor peripheral neuropathy and took B12 shots every day for 2 wks, then was told to have them once a month. My level to begin with was around 180. What should my level be now? I feel confident that my doctor instructed me appropriately, as he is actually the doctor who first wrote a paper and 'discovered' the link between B12 deficiency and PN, but I'm now wanting to question what my level is now, and what your "number" is for what may be optimal, considering your success with the treatment. I have been in a wheelchair now for 9 mos., am on Lyrica, Neurontin, Valprioc Acid, Pristiq, and Vicodin - all of which provide some relief, but only if I keep my feet propped up most of the time and rest with my hands elevated (my pain is in my feet and hands with all the classic symptoms). I've had 2 NCSs and 2 EMGs, all of which showed damage. I'm 39, non-diabetic, have had a normal MRI and lumbar puncture, tried a gluten-free diet, aspirin therapy, and next week I have an Evoke Potential test, and a nerve stimulator has been suggested, along with a neuromuscular specialist. Only thing not addressed so far, which I have repeatedly complained of, is an 'aching' of the bones in hands and feet - literally feels like they are broken at times, particularly if I'm late on taking my meds. Could B12 be more of a solution than what has been tried thus far? Also, do you have any suggestions regarding any other supplements?
Any help would be greatly appreciated - from you and anyone else! Thanks, Trish |
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10-17-2010, 09:11 AM | #10 | |||
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Wisest Elder Ever
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With a very low level of B12 for a long time period... it may take a while to recover. If there has been permanent damage to the spinal cord from the low levels, there may not be 100% resolution.
This post link has a copy of the paper by Dr. Snow, which is from 1999. His take which I bolded there is that patients with neurological problems may have to be kept at higher than typical range for treatment, than most others: http://neurotalk.psychcentral.com/post698522-70.html The cut off in US now appears to be 400. But following Dr. Snow's advice, would mean you should strive for higher. I'd say at least 1000. You can reach that goal by taking oral properly. 5mg of methylcobalamin (which is the active form) daily on an empty stomach has worked for many on this forum. Many doctors don't know about active form, being available and so hence they still use the synthetic which some people cannot activate in the body. That link above I gave, is from the B12 thread, which has medical links and explanations about the various treatments and reasons for them. So please read it carefully, the whole thread, and perhaps then your path may be clearer.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei ************************************ . Weezie looking at petunias 8.25.2017 **************************** These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
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