I have experienced symptoms of peripheral neuropathy for the past two and a half years. A biopsy recently showed that it is a non-length dependent peripheral neuropathy. I have not had any other positive tests, except a mildly high B6 level (low to mid 40s), which was well after a year of symptoms and probably related to a B-complex vitamin I was taking back then. It was slowly coming down on the last set of blood work. I am currently taking:

B12 (methylcobalamine): 5000 mcg
folate (methylfolate): 1000 mcg
D3: 2000 IU
CoQ10: 100 mg
curcumin: 500 mg
biotin: 1 mg
acetyl-l-carnitine: 750 mg
Mg (chelate): 66% RDA
B1 (benfotiamine): 300 mg
vit C (Ester C): 500 mg
r-lipoic acid: 100 mg
omega 3: EPA 650 mg and DHA 500 mg

astaxanthin: 4 mg
vit E: 400 IU
B2 (riboflavin): ?
B3 (niacin): ?

I have dosing questions on the last 4. I am not currently taking the B2 and B3, but am curious. The first group I gathered dosing information from here. Thanks. My main question is a dosing schedule. Other than B12 on an empty stomach and to stay NPO for about an hour after, I have been unable to find any additional information. Are some better to take in the AM or PM? Are there ones that I should take together? Are there ones that I need to separate? Is there anything I am not taking that you would recommend?

Sorry about the long post and I look forward to any input.

Thanks

What is "NPO"?

latin (nil per os): nothing by mouth

It's a commonly used medical abbreviation.

B2 is riboflavin and essential to converting B6 to its active form called pyridoxal, in the body.

You could just take a multivit with B's in it, and that may be enough.

Centrum senior or a generic of it is good, because it has trace minerals and NO iron. There will be B3 in it. (Niacin is also made in the body from tryptophan).

You will want to take nicotinamine (most common form in vitamin mixtures), because niacin itself causes flushing and similar burning the resembles some PN symptoms.

Your list is very complete, and you should see improvements within 3 months or sooner.

If you do not...consider dietary changes to find any triggers there for your symptoms. Gluten, nightshade veggies, dairy, corn, etc. Gluten is the most common one.

Thanks. I'm try to avoid a B complex, due to the slightly high B6 levels. Is the RDA for B2 and B3 enough? Are there any others that I should take on an empty stomach? Are there certain ones to avoid taking together?

Thanks again.

The basic truth about "high" B6 is that--

the levels that appear on lab reports were not originally done on people taking supplements. Lab ranges are only a statistical sample of what to expect. They are not cast in stone, and do not reflect many things. For example, there are lab studies showing Autistic patients with higher than ave B6 readings when NO vitamins are taken. (however maybe fortified foods contributed, but no one knows).

So modest elevations in serum B6 do not reflect much unless really really high or very very low... Like magnesium and other nutrients serum labs can be misinterpreted or given weight when they shouldn't.

It takes really high B6 to cause any neurological symptoms.

And yes, a multivit may be enough for you and most people.

Hello- I am new to the group and have been trying desperately to find the thread in the stickies that lists the supplement/vitamin protocol that's recommended by many(as I've gathered from reading posts). I have found a tremendous amount on B12- which was stickie #2, but I cant seem to find the list. I'm sorry to seem so lost but..I am!!

I was diagnosed with lyme disease back in 1999 but think I've probably had it for a lot longer. In what I thought was the beginning, I would get terrible burning skin, mainly in my arms and legs. That fell away but I then had tingly hands and feet off and on for a year or so. Then all of my neuropathy type symptoms seemed to be gone(still had a TON of other things wrong). Then several years ago, I started having terrible achey/throbbing feet that brought me to tears. I was also getting some tingling in my legs and feet. I went and saw a top NYC neuro who did a biopsy and diagnosed me with small fiber neuropathy. I was on IVIG for 3 mos-which was hell- and though my symptoms didnt really improve much-my repeat biopsy showed major improvement(still don't get that one)!

Fast forward 4 years and in the spring of 2009 I woke up with such terrible burning feet. I still have this incredible pain 22 months later and it's been traveling up my legs,spine, random hot spots, etc. I have always had burning in my thighs and stomach at night but was always told it was a lyme symptom NOT neuropathy so I never thought it was the same-and honestly-am still not sure? Anyway, my feet have been burning ever since and I'm terrified at what seems to be a progression up my legs. I am on 3600 mg's of neurontin as of 12 days ago but have been on increasing neurontin for almost 2 years. The med will last about 60-90 days and then I have to increase again. This time around, it doesnt seem to be kicking in and giving me complete relief like it has in the past.

Because of this horrific symptom, I went on the attack against the lyme again. I have been aggressively treating it for almost two years and feel like things with the SFN are only getting worse as I mentioned.

I've been sick with lyme since I was 26 years old. Now, 12 years into the lyme, I have this second disease which is coming across as if it's even more harmful then the lyme(which has stolen a LOT of years from me). I'm in a state of panic and paralysis. The questions that race through my mind are terrifying...AND no DR will give me the answers!!!

I am on a lot of supplements and would be incredibly grateful if someone could point me to the list on this site for comparison...I thank you SO much for any time you could spare!!

Sincerely,
Katie

Supplements for each person vary depending on what their problems are.

I suspect your Lyme treatments depleted certain nutrients and this may have led to your current problems.

Some antibiotics also CAUSE neuropathies...the fluoroquinolone family.

So if you post more details of what drugs you took or are still taking, I can look them up for you.
Most drug damage involves DNA and mitochondrial functions.

Is anyone using velvet antler?

I am considering using it for improved strength, muscle recovery, energy (hopefully), and well-being.

oh....

I researched this a while back. Those elk herds since then have been ravaged by the "wasting disease"...that deer are getting.

Because it is so similar to Mad Cow....I'd be worried about it.

http://www.liebertonline.com/doi/abs...ournalCode=act