It cannot hurt. But realize that unless you get testing, you won't know if B12 is an issue for you.

The Benfotiamine in it is also useful, but no in every patient with PN.

This supplement tends to cost more than buying the ingredients separately.

More discussion on R-lipoic acid:

http://neurotalk.psychcentral.com/thread159210.html

We all can always learn something new...and this thread illustrates THAT!

Another thread with discussion of R-lipoic acid stabilized:
http://neurotalk.psychcentral.com/thread130991.html

Coenzyme Q10 (CoQ10) is present primarily in the mitochondria.

In a thread on this site, it has been suggested that "damaged mitochondria are at the heart of many forms of [Peripheral Neuropathy]."

CoQ10 generates energy in the form of ATP. "Muscle and nerve cells are big users of ATP."

Statins are known to cause peripheral neuropathy and they are also believed to lower CoQ10.

CoQ10 functions in every cell of the body to synthesize energy, and supplementation can help heart, brain, gums, etc.

It is fat-soluble and best taken with meals containing fat. Some have advised to take it with the fattiest meal of the day for maximum absorption.

"Synthesizing CoQ10 is a complex, 17-step process that requires multiple vitamins and enzymes," according to Ross Pelton.

Recommended dosages range from 30 mg to 300 mg or higher.

"CoQ10 has an excellent safety record."

Related Article: Bioavailability of CoQ10 by Dimitri Papadimitriou, Ph.D.

I just finished skimming this thread for mention of Vit-C. I didn't see much, and those who said they take it, don't take much, e.g., one person said they only take 500 mg.

The reason I ask is because I just got bloodwork done on Thursday, and the company which does it has a flyer listing all the Nutrients, along with how common the deficiency is, plus "What It Does."

Vitamin C:

Is that a typo?

What are therapeutic doses of Vitamin C?

I usually take 1,000mg to 1,500mg/day. One time I took about 7,500mg.

Most of the talk about Vit-C I've seen is about its immune system help and antioxidant value, not its mitochondrial support or nerve system support value.

I take 500mg a day Ester C.

Vitamin C is showing promise in RSD... as an antioxidant, to prevent spread and help control it. Some studies done on surgical patients in UK showed it prevented RSD in fact in about 1/3 or so.

Yes, C and E are both good. Getting all kinds of supplements and healthful foods and low sugar are good.

http://www.lef.org/protocols/neurolo...ropathy_01.htm

How did you decide 500 mg?

I tend to run acidic... and acidic conditions tend to make pain worse. My response to AlkaSeltzer, makes me want to be less aggressive with Vit C. I don't take the Vit C every day... mostly around 3 to 4 times a week.

Also really high Vit C is not recommended for diabetics or prediabetics as it has shown potential increasing cardiovascular risks.

http://www.diabetesincontrol.com/art...tes-news/2255-

In winter I eat oranges, and do not drink orange or other juices.
In summer is when I typically have more Ester C since oranges are out of season. I can basically tell when my gums act up that I need more C that week.

http://www.sciencedaily.com/releases...0715135353.htm

This has implications for peripheral neuropathy if I am not mistaken.

Given the low cost and apparent low risk of Vit-C, it seems worth some more investigation and research.

Incidentally, I noticed there are evidently many people searching online for info about Vitamin C and nerves (see Google suggestions), but there isn't much in the results - yet.

P.S. I read that GABA supplements don't pass the blood-brain barrier, so maybe Vit-C, the indirect route, is viable.

I have a question. I have done a lot of reading regarding using supplements to help with PN. I know that certain vitamins/Minerals inhibit/aid in the absorption of others, so my question is how do you know what you can take together and what should be taken separately? Is there a better time of day and to take on empty/full stomach? I get so confused so I was wondering if there was a website or if someone could explain it to me? TIA