I Took 600 mg of alpha lipoic at Bed time and have nausea today. Could be that. Is tht too much?

Thanku
Tulips

Take it with food.

All of the studies use 600mg or more a day.

The new r-lipoic is better, and you use less.

1/2 of the alpha lipoic is not active, since the product is a mixture of two types. So the r-lipoic can be used at about 100mg a day or so, because it is so much more potent.

Some people do complain of stomach upset. So take it with food.

For approximately a month now, I've been taking 600 mg a day of r-lipoic with food. I have not experienced any stomach upset. Nor have I experienced any increase in energy (which was raised by, I think, mrsD, as a possible benefit of r-lipoic).

--acidy stomachs taking large doses of alpha-lipoic--it is, after all, an acid.

I second the idea of taking it with food, or trying the R-lipoic version, which, since it is composd only of bodily-active isomers of the molecule, can be effective at saller doses. I've found at 100mg/day of R-lipoic I don't have any acid stomach, which I did have sometimes on 600mg alpha lipoic.

I am curious if anyone has tried Thorne Industries r-Lipoic? I am using a product called Thorne Thiocid, but was thinking to switch.

I use Doctor's Best Brand.

I've read that r-lipoic should be twice as potent as ALA. I'm calculating that on iherb.com, Doctor's Best R-Lipoic Acid is about 3.4 times as expensive as Jarrow Alpha-Lipoic Sustain, when calculated on a $ per gram basis. So the ALA seems to be a better value to me. If the r-lipoic were less than 2 times as expensive then it might be the way to go, but it's not even close. I have been using the Jarrow for years and find it effective in reducing my pain.
Electron

We really can't make those assumptions. The purified form may be more readily absorbed. Things like that.

But you stick with what works for you. That is the bottom line.

Here is some reading:
http://www.nutritionreview.org/libra...ipoic.acid.php
From what I gather there, it is more than 1:1 actions.
Removing the inactive form, increases activity of the remaining form.

I never had any results from the old ALA... but I do like the r-lipoic. That is just my opinion.

--give about a 1:5 to 1:8 conversion factor for alpha lipoic vs. r-lipoic (though I'm not sure just how some of these studies make this determination other than trying different amounts and surveying users as to their subjective sense of symptom reduction).

A 1:6 ratio is often cited--100mg of R-lipoic is roughly equivalent in effect to 600mg of alpha-lipoic. (That would help with the expense issues if relatively accurate across people). I myself went from 600mg/day alpha to 100mg/day R-lipoic without appreciable symptom difference.

One can also get an indication by the way the capsules are made.
100mg is the highest dose for r-lipoic.

Lipoic acid works slowly anyway, so noticing what is happening takes time, and many people give up if the timing is long.

The studies were for at least 60 days.