I take my R-Lipoic with my Acetyl L-Carnitine and I have noticed a urine smell with doses of higher than 100 mg on the r-lipoic and higher than 500 mg ALC. I'm experimenting to see which one is causing it.
Smells a little like after I have eaten asparagus. |
MrsD, what is the most efficacious daily dose of th r-lipoic?
I take 100 mg and wonder if it's too low. Any suggestions?
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I take 100mg of the stabilized form too. I think it works.
Some of the charts I found on the web showing absorption, show the R-lipoic stabilized is far more absorbed than the old ALA. http://www.geronova.com/node/61/doct...?theme=retzone The Doctor's Best form has this trademark on the ingredients panel, in tiny print. As the months pass...it seems to work slowly for me... I FEEL better, more alert, etc. I haven't had burning in my feet for a while now either. My hands and feet are not as cold as they were last winter. My A1C came down, but my fasting morning sugars are still a bit up. I may try adding another 100mg later in the day. Taking 200mg all at once didn't agree with me and...made me irritable. But perhaps dividing it up will work? I was using another R-lipoic product, from SourceNaturals, and I guess it wasn't working as well (does not say stabilized on the label). We learn something everyday here! (including me). I also use 150mg of Benfotiamine daily... and this combo may be also part of the reasons for my responses. I take my R-lipoic on an empty stomach first thing in the morning. Over the past decade these are the nutrients that have been improved upon, to deliver better response for people: R-lipoic (improved Alpha lipoic acid) Methylcobalamin (improved activated B12 (cyano synthetic) )) P5P ( activated pyridoxine B6) Benfotiamine ( improved longer acting thiamine B1) Bioenhanced curcumin (improved over 95% extract) Ubiquinol (improved CoQ-10) Zinc monomethionine ( zinc sulfate which is very upsetting to GI) acetyl carnitine (better absorbed than L-carnitine) magnesium chelates (much improved over magnesium oxide) I am running into a blank, at this point... too early in the morning I guess? ;) |
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Something bothers me about that chart, as well as getting study data from the company that mfrs./sells the product. I see that they're citing studies done by others, but IME, purveyors of products do tend to cite only studies that support their claims, even when there are other studies that contradict. (I'm not saying that's the case here - I don't know.) The bar chart http://www.geronova.com/content/bio-...uble-rla-salts (is that the one you're referring to?) seems to indicate that Alpha Lipoic Acid is better absorbed than R-Lipoic Acid :Scratch-Head:, when other sources have been telling us that RLA is better absorbed, and we're only needing 1/6 the dose as of ALA. I guess I'd just feel better about it if there were corroborating independent studies. All those "improved" nutrients - I'm beginning to wonder if at least some of them aren't just so much smoke & mirrors... Doc |
The way I see that bar graph is that RLA is 40 times more absorbable than ALA... If anything I think that is a stretch and I really don't think it is that much. Maybe 10 times or thereabouts?
Why the unstabilized is so low, is a mystery too. But lacking time to look elsewhere, I put that up as an example. Also within the manufacturers is LEF which cleverly makes their product look like it has MORE NaRALA in it by listing the total weight of the salt in its ingredients! Doctor's best does not inflate their product this way, and labels it more accurately. example: Doctor's Best says 143mg sodium RALA yielding 100mg/cap. LEF does the reverse! Quote:
Labels and ingredients are really tricky! One always has to watch carefully. Hubby is waiting for me now to go out with him. I'll look around later today, and get back to this thread if I find better data. I don't really "love" that graph that much either. Quote:
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I spoze it's possible that they transposed the unstabilized RLA and ALA labels, but that would be really (nigh unforgivably) sloppy... :disapproval: Doc |
This is the reason for that graph:
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Urinary excretion of ALA (regular type) http://www.ncbi.nlm.nih.gov/pubmed/14551180 A 1998 paper: http://www.ncbi.nlm.nih.gov/pubmed/9876998 Quote:
http://www.ncbi.nlm.nih.gov/pubmed/19664690 |
I take ALA Max Cr by Xymogen, AMAZING. Also Benfotiamine by Life Extention. The brands my doctors like. I haven't been here in a long time. They have almost healed my feet completely. Brands and amounts are imporatnt. I am very thankful.
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Interesting, ALA is a body building supplement in lower doses
http://www.bodybuilding4u.com/bodybu...ipoic-acid.htm |
Yes, the bodybuilding community uses ALA and carnitine quite a bit.
I've started slowly increasing my RALA to 2 a day (200mg). Splitting the dose up to 100mg in the morning and 100mg at 4pm before dinner, is working out so far. I've added tryptophan again at night 500mg...and that is helping me sleep. I also made a "magnet pad" with 4 one inch neodyms in it to lie on in bed, to help my back pain. It seems to be working well. The hand sewing was tough on my hand, so it is wrist brace time for a couple of weeks at night for my carpal tunnel. I am experimenting with the pad style, and have some new mags coming from Amazon. My mix of PN and arthritis is quite painful in winter, esp when there are storms and Lows like these past few days.:rolleyes: |
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