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Old 03-11-2011, 01:00 PM   #1
Nervous
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Default L-Lysine

I am having a relapse of my burning sensations in my legs and feet. Somewhat in my hands as well.

I am wondering about the following: I recently dropped L-lysine from my regimen of daily supplements. Could this be the cause of my relapse?

Also, I'd be grateful if someone would remind me of why we are taking L-lysine. My search in on Wikip. didn't tell me much, and my search of this forum only brought me two results, which turned out to be my own earlier posts.

Thanks!
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Old 03-11-2011, 01:12 PM   #2
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There are two main reasons for l-lysine...

1) to prevent or reduce a herpes outbreak or shingles pain

2) to counter the use of high dose arginine (which may activate latent herpes).

Here is some general info on it:
http://en.wikipedia.org/wiki/Lysine
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Old 03-11-2011, 02:54 PM   #3
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Quote:
Originally Posted by mrsD View Post
There are two main reasons for l-lysine...

1) to prevent or reduce a herpes outbreak or shingles pain

2) to counter the use of high dose arginine (which may activate latent herpes).

Here is some general info on it:
http://en.wikipedia.org/wiki/Lysine


If L-lysine mitigates my burning pain, should I conclude, then, that I have shingles?

Or am I taking a wildly simplistic approach here?
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Old 03-11-2011, 03:04 PM   #4
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If you had chickenpox as a child, you can have pain, generated by the latent virus. It does not always make vesicles or rash.

I am also of the opinion that herpes can do it too, since they are related.

If the lysine works for you, I'd take that as a sign!

There is a diet to balance arginine/lysine.

http://www.herpes.com/Nutrition.shtml
One wants to keep arginine lower in ratio to lysine if one has a history of any herpes.
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Old 03-11-2011, 03:08 PM   #5
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Quote:
Originally Posted by mrsD View Post
There are two main reasons for l-lysine...

1) to prevent or reduce a herpes outbreak or shingles pain

2) to counter the use of high dose arginine (which may activate latent herpes).

Here is some general info on it:
http://en.wikipedia.org/wiki/Lysine
Quote:
Originally Posted by mrsD View Post
If you had chickenpox as a child, you can have pain, generated by the latent virus. It does not always make vesicles or rash.

I am also of the opinion that herpes can do it too, since they are related.

If the lysine works for you, I'd take that as a sign!

There is a diet to balance arginine/lysine.

http://www.herpes.com/Nutrition.shtml
One wants to keep arginine lower in ratio to lysine if one has a history of any herpes.


Is it possible that my small fiber neuropathy symptoms are, in fact, shingles symptoms? Or is shingles a kind of SFN?

Last edited by Nervous; 03-11-2011 at 03:29 PM.
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Old 03-11-2011, 03:59 PM   #6
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Shingles is a form of neuropathy. I believe it lives in the dorsal root ganglia in the spinal cord.

It is called Post herpetic neuraglia.
http://www.mayoclinic.com/health/pos...ralgia/DS00277

I have had shingles down my right arm, and I still get pain from it now and then.

It can occur anywhere from the distribution of the chickenpox you had when younger.

I believe it is called a ganglionopathy:
http://www.ehow.com/facts_6388067_ga...uropathy_.html

If you suspect shingles you can have blood work for the titres of the antibodies to the virus. Several ones can be done. I had both simplex and zoster run when I had my shingles because they were in an odd place (usually it is across the torso chest back area). My zoster titres were very high, but simplex low.
So I took antivirals for quite a while, and also during 2 severe pain outbreaks. That was a decade ago.
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Old 03-11-2011, 06:56 PM   #7
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Quote:
Originally Posted by mrsD View Post
Shingles is a form of neuropathy. I believe it lives in the dorsal root ganglia in the spinal cord.

It is called Post herpetic neuraglia.
http://www.mayoclinic.com/health/pos...ralgia/DS00277

I have had shingles down my right arm, and I still get pain from it now and then.

It can occur anywhere from the distribution of the chickenpox you had when younger.

I believe it is called a ganglionopathy:
http://www.ehow.com/facts_6388067_ga...uropathy_.html

If you suspect shingles you can have blood work for the titres of the antibodies to the virus. Several ones can be done. I had both simplex and zoster run when I had my shingles because they were in an odd place (usually it is across the torso chest back area). My zoster titres were very high, but simplex low.
So I took antivirals for quite a while, and also during 2 severe pain outbreaks. That was a decade ago.



I was tested in 2008. My titres showed that I did not have simplex, and I do not recall that anyone said anything about zoster-specific titres. I had neuralgia, but my symptoms were atypical of shingles. In spite of this, and having no better diagnosis, they said it was shingles and called it a day.

Two years later, I had a new and different un-diagnosable pain in my foot. Upon examination of the foot issue, a rheumatologist diagnosed me with small fiber neuropathy.

Since the prognosis and treatment for shingles and the prognosis and treatment for SFN are about the same, I am wondering whether it makes a practical difference what I have.
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Old 03-12-2011, 04:03 AM   #8
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Well, the antiviral drugs do work. We had a person here way back in the early 2000 on our old board with severe pain in the back/chest. She finally had testing and got Famvir for it, and it cleared the pain for her.

So if you have been tested and show high zoster titres I think trying the antiviral may give you some pain relief.
Zovirax, Famvir or Valtrex are the typical antivirals used.

Otherwise all you have is high dose l-lysine.
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Old 03-12-2011, 08:26 AM   #9
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Quote:
Originally Posted by mrsD View Post
Well, the antiviral drugs do work. We had a person here way back in the early 2000 on our old board with severe pain in the back/chest. She finally had testing and got Famvir for it, and it cleared the pain for her.

So if you have been tested and show high zoster titres I think trying the antiviral may give you some pain relief.
Zovirax, Famvir or Valtrex are the typical antivirals used.

Otherwise all you have is high dose l-lysine.


I was on Valtrex for a full course, without result.

How "high" a dose of L-lysine are you suggesting?

Thanks!
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Old 03-12-2011, 08:53 AM   #10
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I would start at one gram a day, and work up to 2. Take 2 grams a day for a month and see what develops for you.
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