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Old 07-26-2012, 08:17 AM #1
WayneR WayneR is offline
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Thank you so much. I assumed that it had to be something like that. It is strange, however, how stretching the skin slightly like closing my hand or the breeze on my face or the movement of my clothing can be painful.
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Old 08-22-2012, 09:59 PM #2
Idiopathic PN Idiopathic PN is offline
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Thank you so much. I assumed that it had to be something like that. It is strange, however, how stretching the skin slightly like closing my hand or the breeze on my face or the movement of my clothing can be painful.
Hi. I have the same over-sensitivity in my skin - legs, arms sometimes back and face. I also have painful feet. So far, there has been no cause found in my condition. Mine started in all the areas I mentioned. Do you feel pain with the touch of your sheet? I do.

I don't know if this common, when I wake up in the morning I don't feel the stinging (like sunburned skin), burning sensations. But once I get up, there it goes again.

I take gabapentin and a whole bunch of supplements. I just recently increased my gabapentin dosage from 1200 to 1500mg. It makes the pain tolerable. For two days now I'm using Lidoderm patch for the feet. It is not 100% pain free feet but it makes me move around.
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Old 08-31-2012, 06:40 AM #3
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Lightbulb

Gadolinium:

Here is more information on this contrast agent:

http://www.fda.gov/Drugs/DrugSafety/.../ucm142889.htm
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Old 09-29-2012, 03:52 AM #4
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Lightbulb Video illustrating dorsal root pathways:

http://www.medscape.org/viewarticle/754961

This Medscape video is very good at describing the dorsal roots along the spine, and explaining neuropathic pain.

You may have to pause it when the slides come up listing treatments, as they are very brief.

This video requires a membership to Medscape which is free and easy to do. Medscape from then on will be accessible to you and there are many good features there on health topics in general.
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Idiopathic PN (08-09-2013)
Old 04-09-2013, 12:42 AM #5
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Quote:
Originally Posted by Idiopathic PN View Post
Hi. I have the same over-sensitivity in my skin - legs, arms sometimes back and face. I also have painful feet. So far, there has been no cause found in my condition. Mine started in all the areas I mentioned. Do you feel pain with the touch of your sheet? I do.

I don't know if this common, when I wake up in the morning I don't feel the stinging (like sunburned skin), burning sensations. But once I get up, there it goes again.
There is a strong circadian pattern to my NLD SFN/G. When I get up in the morning all is well. However across the day, burning in my thighs, arms and face gets worse. I'm typically most miserable in the evening when I am trying to relax after work. It may be that I have fewer opportunities to get fully engaged in a task that limits my awareness of pain, but watching TV at night is a high probability time to notice pain. Probably a statement on the quality of TV programming.
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Old 04-09-2013, 06:02 AM #6
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There is a strong circadian pattern to my NLD SFN/G. When I get up in the morning all is well. However across the day, burning in my thighs, arms and face gets worse. I'm typically most miserable in the evening when I am trying to relax after work. It may be that I have fewer opportunities to get fully engaged in a task that limits my awareness of pain, but watching TV at night is a high probability time to notice pain. Probably a statement on the quality of TV programming.
I would wonder if you have an inflammatory thing going on?

Late afternoon is when your cortisol levels dip, and they come up a bit after dinner. Then fall again around 4am. Cortisol is your natural anti-inflammatory, from the adrenal glands.

You could try our AlkaSeltzer original formula trick, to see if
it helps. If it does then you have some inflammatory thing going on with your PN. AlkaSeltzer works fast, and has aspirin in it in solution, so is less irritating to the stomach. Do not use if you take blood thinners or have a bleeding disorder.

There are several versions of AlkaSeltzer, don't choose the Cold types. Original formula is the one that works.

Inflammatory types of PN can be arthritic, lupus, compressions in the spine, etc. Eating an anti-inflammatory diet may help.
Also some natural anti-inflammatories like bromelain (enteric coated), curcumin, quercetin, etc, may work too.

Did I ask you about using any ACE inhibitor drug for hypertension? If you use one, this could be causing your problem too. They raise bradykinin in the body, which dilates blood vessels and this puts pressure on nerves.
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Last edited by mrsD; 09-04-2014 at 04:38 PM. Reason: Fixing grammar and spelling
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Old 04-09-2013, 06:05 PM #7
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Quote:
Originally Posted by mrsD View Post
I would wonder if you have an inflammatory thing going on?

You could try our AlkaSeltzer original formula trick, to see if
it helps.

Did I ask you about using any ACE inhibitor drug for hypertension? If you use one, this could be causing your problem too. They raise bradykinin in the body, which dilates blood vessels and this puts pressure on nerves.
... the "AlkaSeltzer Trick." It sounds like something out of James Bond. Is there a string you could point me to that discusses the specifics of the AT? (like when to take, what to look for?, etc,)

I am on Ramipril 10mg for hypertension. I'm not sure if that is an ACE inhibitor.

I'll try and post something in the new members section over the next day or two, as I am new to the board and just started posting in out-dated threads.

Thank you!

Mike
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Old 04-14-2013, 05:51 AM #8
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Quote:
Originally Posted by amike View Post
... the "AlkaSeltzer Trick." It sounds like something out of James Bond. Is there a string you could point me to that discusses the specifics of the AT? (like when to take, what to look for?, etc,)

I am on Ramipril 10mg for hypertension. I'm not sure if that is an ACE inhibitor.

I'll try and post something in the new members section over the next day or two, as I am new to the board and just started posting in out-dated threads.

Thank you!

Mike
YIKES....you are using an ACE inhibitor and have PN symptoms?

That is a sign to get that drug changed. I am recovering from Lisinopril, which became so toxic I was having a nightmare suddenly of severe severe pain and swelling. You can get swelling in your throat suddenly, as the bradykinin builds up and have a major emergency! I'd discuss changing the drug immediately and see if your symptoms improve. I am suspecting they will.

On top the bradykinin elevation, I also had a drug induced lupus from the ACE inhibitor which made my joints inflamed and also
created a mysterious rash on both my forearms.

Your specific ACE inhibitor also can cause liver damage. Another reason to get it changed.

Please consider this, as it might fix your problems.

bradykinin:
http://en.wikipedia.org/wiki/Bradykinin

People vary in how they metabolize this bradykinin away.
Bradykinin reactions in normal people are called acquired angioedema. But if you have a genetic error in this metabolism, you could have another form of angioedema which makes you most sensitive and likely to have reactions.
This is called HAE..
http://www.haea.org/

I think anyone with PN taking an ACE inhibitor is at risk of this buildup of bradykinin and hence symptoms of that.
It took 10 yrs + for my reaction to go ballistic. So time means nothing if you have been on these drugs for a while. I am now on a very small dose of beta blocker which is working so much better on my BP and has no side effects!

As far as AlkaSeltzer goes just take one packet of two and see if things get better. If it does, that points to inflammation as a PN component. This form of aspirin is pretty safe because it is in
solution and therefore absorbed very quickly and doesn't hang around the stomach to irritate anything. If you use any blood thinning drugs, or have stomach ulcers you need medical
permission to use any aspirin product.
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