I am starting this thread to put up links to information about this common trigger for peripheral neuropathy.
Anyone who wants to ask questions or contribute experience and/or more links is welcome:
This is a link to a paper on impaired glucose tolerance, which may precede type II diabetes by many years:
http://www.citeulike.org/user/wrs1/article/6499468
Quote:
Idiopathic neuropathy, prediabetes and the metabolic syndrome.
by: A. Gordon Smith, J. Robinson Singleton
Journal of the neurological sciences, Vol. 242, No. 1-2. (15 March 2006), pp. 9-14. doi:10.1016/j.jns.2005.11.020 Key: citeulike:6499468
View FullText article
DOI, Pubmed, Hubmed, Pubget
Abstract
Peripheral neuropathy is a common problem encountered by neurologists and primary care physicians. While there are many causes for peripheral neuropathy, none can be identified in a large percentage of patients ("idiopathic neuropathy"). Despite its high prevalence, idiopathic neuropathy is poorly studied and understood. There is evolving evidence that impaired glucose tolerance (prediabetes) is associated with idiopathic neuropathy. Preliminary data from a multicenter study of diet and exercise in prediabetes (the Impaired Glucose Tolerance Neuropathy Study) suggests a diet and exercise counseling regimen based on the Diabetes Prevention Program results in improved metabolic measures and small fiber function. Prediabetes is part of the Metabolic Syndrome, which also includes hypertension, hyperlipidemia and obesity. Individual aspects of the Metabolic Syndrome influence risk and progression of diabetic neuropathy and may play a causative role in neuropathy both for those with prediabetes, and those with otherwise idiopathic neuropathy. Thus, a multifactorial treatment approach to individual components of Metabolic Syndrome may slow prediabetic neuropathy progression or result in improvement.
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And I just found this article while searching something else the other day:
http://www.ncbi.nlm.nih.gov/pubmed/21205116
new information as of 2011:
Quote:
Diabetes Obes Metab. 2011 Mar;13(3):243-50. doi: 10.1111/j.1463-1326.2010.01344.x.
Chronic treatment with D-chiro-inositol prevents autonomic and somatic neuropathy in STZ-induced diabetic mice.
Farias VX, Macędo FH, Oquendo MB, Tomé AR, Báo SN, Cintra DO, Santos CF, Albuquerque AA, Heimark DB, Larner J, Fonteles MC, Leal-Cardoso JH, Nascimento NR.
Source
Department of Physiology and Pharmacology, Superior Institute of Biomedical Sciences, Fortaleza, Ceará, Brazil.
Abstract
AIM:
D-chiro-inositol (DCI) has been shown to prevent and reverse endothelial dysfunction in diabetic rats and rabbits. The present study evaluates the preventive effect of DCI on experimental diabetic neuropathy (DN).
METHODS:
Streptozotocin-induced (STZ) diabetic mice were treated by oral gavage for 60 days with DCI (20 mg/kg/12 h) or saline (NaCl 0.9%; 0.1 ml/10 g/12 h; Diab) and compared with euglycaemic groups treated with saline (0.1 ml/10 g/12 h; Eugly). We compared the response of the isolated sciatic nerve, corpora cavernosa or vas deferens to electrical stimulation.
RESULTS:
The electrically evoked compound action potential of the sciatic nerve was greatly blunted by diabetes. The peak-to-peak amplitude (PPA) was decreased from 3.24 ± 0.7 to 0.9 ± 0.2 mV (p < 0.05), the conduction velocity (CV) of the first component was reduced from 46.78 ± 4.5 to 26.69 ± 3.8 ms (p < 0.05) and chronaxy was increased from 60.43 ± 1.9 to 69.67 ± 1.4 ms (p < 0.05). These parameters were improved in nerves from DCI-treated mice (p < 0.05). PPA in the DCI group was 5.79 ± 0.8 mV (vs. 0.9 ± 0.2 mV-Diab; p < 0.05) and CV was 45.91 ± 3.6 ms (vs. 26.69 ± 3.8 ms-Diab; p < 0.05). Maximal relaxation of the corpus cavernosum evoked by electrical stimulation (2-64 Hz) in the Diab group was 36.4 ± 3.8% compared to 65.4 ± 2.8% in Eugly and 59.3 ± 5.5% in the DCI group (p < 0.05). Maximal contraction obtained in the vas deferens was 38.0 ± 9.2% in Eugly and 11.5 ± 2.6% in Diab (decrease of 69.7%; p < 0.05), compared to 25.2 ± 2.3% in the DCI group (p < 0.05 vs. diabetic). Electron microscopy of the sciatic nerves showed prevention of neuronal damage.
CONCLUSIONS:
DCI has a neuroprotective action in both autonomic and somatic nerves in STZ-induced DN.
© 2011 Blackwell Publishing Ltd.
PMID:
21205116
[PubMed - indexed for MEDLINE]
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d-chiro inositol is related to myoinositol which is also called inositol. It has been suggested that diabetics use inositol because it is lost in the urine in people with diabetes. The d-chiro form is just an isomer and is over the counter. It is currently used by the PCOS community to help reverse infertility in women with PCOS. (poly cystic ovary syndrome).
I took it for a year..hoping it would help my A1C and it did not.
A therapeutic dose of d-chiro inositol costs about $60 a month.
This is a reputable brand:
http://www.chiralbalance.com/
I also see that Swanson's has it now, but the dose they offer is very low only...30mg. The chiral balance is 300mg/cap.
I'll be adding to this thread with time. And I repeat -- others who have questions or information to share are welcome.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
09-30-2011, 05:53 AM
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