Reply
 
Thread Tools Display Modes
Old 09-17-2015, 01:10 PM #21
madisongrrl's Avatar
madisongrrl madisongrrl is offline
Member
 
Join Date: Jul 2014
Location: Midwest
Posts: 584
5 yr Member
madisongrrl madisongrrl is offline
Member
madisongrrl's Avatar
 
Join Date: Jul 2014
Location: Midwest
Posts: 584
5 yr Member
Default

Another good link about Histamine Intolerance.
http://www.amymyersmd.com/2013/10/ev...e-intolerance/
__________________
  • Gabapentin, Nortriptyline, & Low Dose Naltrexone
  • Methylcobalamin/Methylfolate, & Vitamin D3/K2
  • Phosphatidyl Choline, Phosphatidyl Serine & Probiotics
madisongrrl is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
DejaVu (09-21-2015), mrsD (09-17-2015)
Old 09-17-2015, 02:11 PM #22
Patrick Winter Patrick Winter is offline
Member
 
Join Date: Jul 2015
Posts: 269
3 yr Member
Patrick Winter Patrick Winter is offline
Member
 
Join Date: Jul 2015
Posts: 269
3 yr Member
Default

Quote:
Originally Posted by madisongrrl View Post
Another good link about Histamine Intolerance.
http://www.amymyersmd.com/2013/10/ev...e-intolerance/
Oddly enough it was my birthday the other day and my wife said, I don't care what this is gonna do to your nerves have a small scoop of Ice Cream tonight! You have to at least have something bad on your birthday! So, I did. I also decided to take a benadryl while no one was looking in anticipation of what was coming after reading these studies posted here. Normally Ice Cream would've had me up all night in buzzing burning pain (and no, i am not a diabetic). After the Benadryl i had almost no pain that night. I was of course tired as heck! I apted to not take my nightly gabapentin because the benadryl basically seemed to take care of the pain and give me the same groggy reaction. I can't see taking something like Benadryl on a daily basis (especially seeing it can cause low DAO), but in my case it definitely supports the connection of histamine and nerve pain/inflammation.
__________________
Diagnosis: Idiopathic Small Fiber Neuropathy (Statin Induced)




R-Lipoic Acid: 100mg - 300mg Daily
Acetyl-L Carnitine: 1500mg Daily
Vitamin B12: 1000 mcg Daily
Magnesium 500mg Daily
Grape Seed Extract 200mg Daily
Benfotiamine 300mg daily

Patrick Winter is offline   Reply With QuoteReply With Quote
"Thanks for this!" says:
madisongrrl (09-17-2015)
Old 02-18-2020, 10:37 PM #23
janieg's Avatar
janieg janieg is offline
Member
 
Join Date: Jan 2014
Location: Maryland
Posts: 778
5 yr Member
janieg janieg is offline
Member
janieg's Avatar
 
Join Date: Jan 2014
Location: Maryland
Posts: 778
5 yr Member
Default

Five years later, an allergist/immunologist is looking at my histamine levels as my potential problem. Sigh.
janieg is offline   Reply With QuoteReply With Quote
Old 03-02-2020, 01:13 PM #24
janieg's Avatar
janieg janieg is offline
Member
 
Join Date: Jan 2014
Location: Maryland
Posts: 778
5 yr Member
janieg janieg is offline
Member
janieg's Avatar
 
Join Date: Jan 2014
Location: Maryland
Posts: 778
5 yr Member
Default

I want to post this information here in case it should ever help anyone.

From Histamine - Wikipedia

"Once formed, histamine is either stored or rapidly inactivated by its primary degradative enzymes, histamine-N-methyltransferase(HNMT) or diamine oxidase(DAO). In the central nervous system, histamine released into the synapses is primarily broken down by histamine-N-methyltransferase, while in other tissues both enzymes may play a role. Several other enzymes, including MAO-B and ALDH2, further process the immediate metabolites of histamine for excretion or recycling."

I believe low levels of HNMT is a contributing factor in my neuropathy. DAO supplements don't appear to help at all. These two SNPs on the HNMT gene have been documented as resulting in reduced levels of HNMT, and thus a reduced ability of breaking down of histamine that could impact proper functioning of the CNS:

rs1050891 - A/A is normal, I'm A/G
rs11558538 - CC is normal, I'm C/T (C314T Thr105Ile)

Both are tested on 23andme, although the second isn't available by SNP name. (Ping me for more information.)

The immunologist who diagnosed currently has me on Zyrtec once a day and 40 mg of famotidine (Pepcid AC) twice a day to try to get my histamine levels down. My plasma histamine level was high in the blood test he ran.

I'm also on a low histamine diet which has helped bring them down as well. one or both actions has pulled me out of a terrible flare I was in caused by three consectutive days on high histamine food consumption. It was so bad that I actually did have a classic allergic reaction. That's what caused me to make an appointment with an allergist/immunologist. I knew it had to be a clue.

I was very fortunate that this doc whose office is two miles from my house is well-versed in Histamine Intolerance and Mast Cell Activiation problems. Not all are.
janieg is offline   Reply With QuoteReply With Quote
Old 05-21-2020, 10:29 PM #25
janieg's Avatar
janieg janieg is offline
Member
 
Join Date: Jan 2014
Location: Maryland
Posts: 778
5 yr Member
janieg janieg is offline
Member
janieg's Avatar
 
Join Date: Jan 2014
Location: Maryland
Posts: 778
5 yr Member
Default

I continue to learn about my condition and determine the "triggers" that cause me to flare and turn into a ball of fire.

Quercetin with bromelain appears to be one of the most helpful supplements as it's a natural antihistamine. I'm also taking palmitoylethanolamide (PEA) with luteolin for its mast cell stabilization properties.

(PDF) New Insights in Mast Cell Modulation by Palmitoylethanolamide

Overall, I'm feeling much better and am doing a decent job of keeping the flares to a minimum. It's a learning process, though, as you have to figure out your triggers, and they're not always consistent. For example, you can make a recipe one day that doesn't affect you, but the next time, it does. The freshness of the meat comes into play, and that can obviously a big unknown.

I so wish MrsD were still around. I think of her often and hope she's doing ok.

janieg is offline   Reply With QuoteReply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
Allergic Reactions? daisy.girl Multiple Sclerosis 14 09-01-2011 12:33 PM
Mestinon and reactions whirlwind123 Myasthenia Gravis 4 09-06-2010 03:47 AM
Medication reactions? Phyxius Traumatic Brain Injury and Post Concussion Syndrome 7 01-15-2010 04:10 AM
MRI with contrast, who else has reactions? dahlek General Health Conditions & Rare Disorders 9 02-06-2008 01:14 PM
Different types of reactions Hanna Gluten Sensitivity / Celiac Disease 4 10-12-2006 11:42 AM


All times are GMT -5. The time now is 07:50 AM.

Powered by vBulletin • Copyright ©2000 - 2020, Jelsoft Enterprises Ltd.
Search Engine Optimisation provided by DragonByte SEO v2.0.31 (Lite) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2020 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.