I think I'll be trying the HS Fighter, and see how that goes. I assume I'm ok to take it on an empty stomach with my Thyroid meds? I've started taking the Thyroid meds at night well after eating. I used to take it in the mornings before breakfast...but, I think I was eating too soon afterwards.

I'm just curious. Should I expect to feel any different (better) taking these new vitamins? I'm obviously going to start them based on my slightly elevated homosystiene levels. I was curious if I could potentially expect any relief from my hypothyroid symptoms? I've had fatigue, joint pain, etc for a long time now. I've basically been told to just live with it. I was hoping this might potentially help with those issues.

These 3 work on many systems...

B12 for example...just one example, ..methylcobalamin is involved in the synthesis of melatonin from serotonin. Melatonin is thought to now be involved in pancreatic functions, so besides better sleep there are other functions we may not even know about!

So yes, you may see some global improvements. People who have the MTHFR mutation see lots of benefits just from methylfolate.

The HS formulas also help the nervous system repair itself.

Hi! After a miscarriage my fertility Dr had me tested for MTHFR. Turns out Im heterozygous for MTHFR A1298C so he suggested Metanx. I then went to my primary Dr and requested a homocysteine level test, which came back normal at 6.6 umol/L.
Im taking: P5P 50mg; Metafolin 2400mcg; Methylcobalamin 2mg (equivalent to Metanx since insurance wont cover it) daily. Should I keep taking all this if my homocysteine levels are OK? Thank You!

That question is for your doctors to answer.

However the MTHFR mutation is sometimes not 100%...
you may be methylating "some", but not enough for other functions besides homocysteine.

Sorry to jump back into this thread yet again. But, I have a new question. Thought perhaps the experts on this forum might have some insight. I've been taking the HS Fighters supplements mentioned a few post above since the time of my last post. I noticed some relatively mild positive results. My energy levels, and just overall health seem to be a bit better.

I decided to add another supplement to my regime that I had been researching for a bit, ZMA. Thought it couldn't hurt to give it a go...my last Testosterone had me just on the plus side of low. I had previously been just on the outside looking in. I had read the T boosting properties of the ingredients in ZMA (Zinc, Magnesium, & B6). But, after a couple of weeks of use I started getting some strange symptoms. The other night I had a hard time getting to sleep. My body (mainly chest) started getting shaky/fluttery. There was no pain to speak of...just uncomfortable at worst. And, my energy level dipped pretty dramatically the following day. Any chance I'm just overdoing it on something? B6 perhaps?

Some people are very sensitive to B6.

I can get too energized on methylfolate, so I only take 800mcg a day of that, and even sometimes skip a day.

Check the magnesium in that ZMA product. If it is OXIDE then you are not going to get much benefit from it, because OXIDE is not absorbed and remains in the bowel.

Also if your HS fighter product has B12 in it, take that on an empty stomach. Food will greatly impair absorption of B12.

mrsD, thanks for the always prompt response. Here are the ingredients:

HS fighters:

Folate (Metafolin L-methylfolate) 800 mcg
Vit B12 (as methylcobalamin) 1,000 mcg
Vit B6 (as pyridoxine HCI) 30 mg

ZMA Tech ingredients:

Vit B6 (as pyridoxine HCI) 10.5 mg
Magnesium (as aspartate) 450 mg
Zinc (as monomethionine & aspartate) 30 mg

Could it be the B6 that's making me feel so rough? I'm almost in a fog..head feels kind of numb...and of course the weird chest flutters the other night. Oh, and I take these two supplements on an empty stomach before bed (along with my levothyroxine 125mcg)

I'd try taking the HS fighters in the morning on an empty stomach.
That folate would give ME the heebeejeebees at night!
But not everyone has that reaction.

The magnesium in the ZMA product should help you relax some.
You could take that every other night and see if you notice any difference. Too much magnesium can over-relax you and make you sleepy.

However, I wonder about that thyroid medication. I had been on 75mcg levothyroxine for over 10 yrs and suddenly it was too much for me. Even at 1/2 dose it was waking me up and I was having rapid heart beats at night. So after a 3month hiatus, I got retested and was still in the normal range for me. Something changed therefore and my thyroid medication was making me very uncomfortable. (I had had hypo before and a goiter in the past). So now I am without and feeling much better. Go figure!