Has anyone heard of this? B1 and B12 and Lipoic Acid and herbal extracts in pill form. 2 pills a day, dosage, 63 dollars a mo. Plus shipping. 3 mo. supply special I think is 129. All the testimonials I read in the Ads look very promising. I hope there will be someone who can give some feedback. I saw some creams advertised at another site and*edit* has a sleeve that reportedly works to heal pain from knee replacements, hip replacements, arthritis , etc. I am about to try anything except surgery.

There are many, many, many posts/threads on this product. You can find them via the Search function.

Doc

We have had many questions about this expensive product.
Its price is way higher than you would pay for the ingredients
separately. Do the search and beware of ads for PN products!
They are numerous and expensive.

It will only work for certain types of PN.

You need to further investigate your PN to determine:
1) what type you have --- there are over 100 types
2) figure out what is causing it
3) investigate the supplements.

For example the B12 in that supplement you ask about does not say to take on an empty stomach. If you are deficient to begin with you need to know why, and if you take it the wrong way, you
will not see benefits.

Use of supplements for DNA damage is quite different.

You need to begin with a medical test for B12 levels, (and get your numbers--don't accept "normal".. because lab ranges are low and out dated. You need to be at 400pg/ml minimum).
Get tested for Vit D at the same time.

And start with providing magnesium to your feet, either in epsom salt soaks, or the new lotion by Morton's --Epsom Lotion.
Available at WalMart and Amazon affordably.
Magnesium levels are quite low in most people today, because of poor diet. If either of these magnesium sources helps, then you can add oral mag supplements (not Oxide form as it is not absorbed).

The cost of fixing these BIG THREE most common nutrients involved with some PN patients is pennies a day.
Low B12 can come from drugs (acid reducing or metformin), and is estimated today to involve 40% of people (and this goes up in those over 50). Both magnesium, and Vit D are thought to be low in up to 70% of people in the US today. When magnesium is low the nerves will act up and give grief.

If your PN is only in your damaged foot and not equally in your other foot, that would be telling.

It would help us here if you went into more detail, about your diet, drinking history if any, if you take statins, or if you took those fluoroquinolones, hobbies, etc. If you were screened for blood sugar abnormalities, if you know your A1C level, if you have relatives with PN, --things like that.

You can certainly buy that expensive product if you want, but be advised it needs to be taken on an empty stomach or the B12 may not be absorbed (if your problem is lack of intrinsic factor).
Methylcobalamin B12 is very inexpensive. We get ours now at Costco for 6 cents a day, as an example.

We have lots of information on this forum, collected over a 6+yr period of time. Please avail yourself of it, and start reading.
The two stickies at the top of the first page are very helpful.
And so is the SubForum listed at the top of the first page here.

Thanks again for your response. My PN is in both feet. I am on a statin, Lipitor for my cholesterol and now changed to a generic version for drug coverage purpose. My blood sugar levels are normal as my last test but will have more info today as I will see my doctor for results of recent lab work. I have been seeing him more of a liver concern so he has been monitoring with blood work and has stopped me with alcohol consumption.

Statins... we need not look further.

This is my statin post:
http://neurotalk.psychcentral.com/post665830-5.html
There are many many statin articles on PN.. Use the search function for more posts. "statin" as a keyword.

Here is a link showing new photos of statin damage to nerves:
http://www.sciencedaily.com/releases...0510150143.htm

Watch Dr. Kendrick MD's video for starters:
http://www.youtube.com/watch?v=i8SSCNaaDcE

Read what we have gathered here, and in the end you will have to decide for yourself.

But I strongly believe that no supplement will reverse statin damage if you continue to use them.

One thing you MUST do is supplement with a quality CoQ-10 product. Qunol or Q-gel is the newest and most absorbable.
Statins affect the enzyme in the liver that makes your own CoQ-10 for you. This nutrient is essential for muscles including the heart muscle, your gums, and proper functioning of the energy cells called mitochondria in all your tissues. Studies have shown that if a person is on a statin everyday, by 5 yrs time, 1/2 of their own CoQ-10 is lost. Losing this vital nutrient is very damaging to muscles and your heart. No real guarantees about
fixing the nerves however, with this supplement. 100mg a day minimum of the new form, or 300mg a day of the older oil based CoQ-10 products.
Qunol is on Amazon and at Costco at reduced affordable prices.
Your weak leg muscles could be statin results.

We have had people here damaged by statins, some have improved when the statin was removed, some have not. But if you continue with it...you will NOT improve with anything we discuss here IMO.
That is your choice. Dr. Jay Cohen MD believes that adequate
cholesterol lowering (if you even believe that works at all), can be had from 5mg of Lipitor a day. (that is 1/2 of a 10 mg tablet)-- He has written a book about this in fact and it is available on Amazon.

There are new studies out now that 5mg of Crestor (the strongest most toxic statin ever), can work adequately taken twice a WEEK. So read up here, search the net yourself, and decide what course you will take. I assure you that your doctor (and almost all doctors) do NOT know the damage they are doing to their patients. So I gather up these medical papers and sites, to provide the other side of the story. Then you can then be informed a bit better to make this decision for yourself.

BTW...statins work on the liver, and can damage it over time. That is another concern you will have to decide upon.
We are coming to the end of statin treatments. New non-statin drugs are on the verge of approval. It won't be long that statins will be a historical anomaly.

MrsD, I'm sorry, I know this is a really old post, but I was wondering, do you still buy your Methylcobalamin B12 from Costco? If so, is it the sublingual kind? Does it contain sucralose? I saw the methylcobalalamin at Costco but they only had the sublingual kind with the artificial sweeteners in it.

I found that if I even eat ONE tiny breath mint containing sucralose I will get horrible violent long drawn-out stabbing pains in my feet, bad enough I had to leave work, so I was afraid to use these. I was wondering what your experience was with sucralose.

Yes, my bottle has sucralose, and mannitol in it.

The Puritan's Pride bottle I have does not... it has mannitol listed.

I don't seem to react negatively to sucralose. But I don't consume much or any significant amount of it daily.

Most B12's are still made for sublingual use...so have a flavoring in them or sweetening agent.
Jarrow does not have sucralose either:
http://www.jarrow.com/product/58/Methyl_B-12
This is available in iherb.com and Amazon.

I just bought "SuperiorSource" No shot Methylcobalamin B12 1000mcg sublingual. They are called MicroLingual as they are small. If you're not lactose intolerant I believe it's a good find. The additives are Lactose and acacia gum. It's available at iHerb.com and many other places. Amazon only has the one that includes Folic Acid and it includes more additives as well.

Mannitol is brutal on my system, I might as well take an EX-LAX.

I have a Jarrow B-12 5000mcg I take but i break it into 4. And just take 1/4th a day because I don't have a deficiency. I have seen a lot of places say that even the 5000 is perfectly safe and others say it could be a bit much and you could see a blood pressure drop from that much. My blood pressure is always in the lower (optimal)end of normal. Don't wanna start getting into low BP issues. I could get there easily.

I have also seen some places say that the body isn't able to ingest the entire dose in the B-12 supplement.

Any thoughts?

http://www.ncbi.nlm.nih.gov/pmc/arti...able/T1/#TF1-4

The second column is a list of absorption of oral in patients with PA (pernicious anemia). They have broken intrinsic factor --which will allow small amounts of B12 to be absorbed in the intestine. Notice that small B12 doses are not well absorbed by PA patients.

In normal patients 1000mcg gives 13mcg absorbed. In PA patients, 12mcg. This illustrates the passive absorption ceiling so to speak.