RE: Excitotoxins

Blocking NMDA receptors with Namenda

Namenda (memantine) is a medication with FDA approval for use in people with Alzheimers. This med acts upon the glutamatergic system by blocking NMDA receptors.

This med is also sometimes used in pain management, for chronic neuropathic pain.

This medication (like so many) has many potentially serious adverse effects, including but not limited to heart issues, nervous system issues (including potential for Tardive Dyskinesia) and many other potential complications. Please ask your pharmacist for potential adverse reactions/side-effect info.

I'd had this med prescribed for me in an attempt to quiet neuropathic pain several years ago. After a 90 day trial, I did not find this med helpful enough, in my case, to further chance the potential complications. The prescribing physician had felt I was overly concerned about the potential adverse reactions. I had kindly/gently, yet strongly, disagreed with him. I was experiencing no noticeable assistance with pain from adding this med for 90 days. Just my own experience with this med. Someone else may experience remarkable results.

Here's an article about NMDA receptor agonists' failures and successes:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534915/

Lessening Exposures to Excitotoxins

It's safer, in my opinion, to lessen exposure to excitotoxins as much as possible.
(I know MrsD also mentions this often.)

See this article for more information:

http://americannutritionassociation....ns-taste-kills

Hope this info. helps somehow.

To Our Healing!

DejaVu

Deja.... do you know about the magnesium lotion? Magnesium also blocks the NMDA receptors in the periphery.

Morton Epsom lotion:
Many of us here use it with great success. It also relaxes muscles and improves circulation.

This is inexpensive and works wonderfully, it even lowers my hypertension to almost normal. I only need a small dose of betablocker now instead of 3 drugs.

Walmart and Walgreen's have it on the shelf...and it is at Amazon online... but not all stores have it yet.
Use about a quarter's diameter once a day...at night if possible.
Divide that up 1/2 for each leg. I find it lasts more than a day for me, so you can rotate locations. A fingertip dollop works for the neck.

http://www.walmart.com/ip/Morton-Uns...fl-oz/23711655

Hi MrsD,

Thanks for mentioning this to me!
I had found this lotion just 2 months ago, by chance, at Walmart.
I use it nightly.
Thanks for the dosage info. I will use it more frequently, and in more areas!

It's good to be back here on the PN forum, and at neurotalk in general!
I am feeling much more hopeful than I was even three days ago.
When I get away from this group for too long, even due to increased illness, I start to feel the options are too limited and the conditions too progressed and it feels hopeless. More options become available and I have had difficulty staying updated on my own.
It's so helpful to be reminded there are options and there is hope!

Many thanks to you and to all members here for sharing so openly and for offering mutual support!

To Our Healing!
DejaVu

NIH has granted $4 million to the company UC Davis founded to pursue this SEH inhibitor approach to treating neuropathic pain.

http://www.centralvalleybusinesstime.../001/?ID=29766

"Now known as EC5026, the compound is “a potent, orally active and a non-narcotic analgesic that does not adversely affect the brain, gastrointestinal tract, or cardiovascular system,” says Alan Buckpitt, the company's vice president of pharmacology and emeritus professor of molecular biosciences at the UC Davis School of Veterinary Medicine. “The compound effectively treats pain in preclinical models at low oral doses with no apparent adverse or addictive effects. Preclinical studies demonstrate efficacy that exceeds current therapies for diabetic neuropathy.”"

________

If it all works out I wonder how long it will take to get to market?

Cliffman

The mention of "early" clinical trials suggests that the process is just beginning. That means 5+years or more.

Namenda 28 mg at night
Memantine 10 mg 1-3 times per day

Amazing!