This was posted on General forum this morning, but it
has potential for PNers IMO....

http://news.ucdavis.edu/search/news_...lasso?id=11258

I'd like to know which "lipids" this article refers to.

It looks like they're concentrating on diabetic neuropathy, which I guess is much more common than for people who aren't diabetics--like me!

My PN is now getting quite severe , my Doctor has raised my Lyrica to 100 twice a day. I am also using the hottest chilli cream, forgot the proper name! Had all the tests, I must say that the specialist l saw for a couple of minutes , I felt disgusted, was of no help at all! I wish all PN suffers well.

I have to wonder if your hot pepper cream (capsaiscin) is making things worse? Many of us here cannot tolerate this product, including me.

I use lidocaine on my feet during a flare. In the US there is a new lotion called Aspercreme lidocaine 4%. But I don't see it in the UK.

If you can ask your doctor for either Lidoderm patches RX, or a cream with 4 or 5% lidocaine made up for you, you could try it.
Apply to the tops of the feet...and up to and including the ankle.
This is a very numbing product and would work better for you I think.

If you get the Lidoderm (lidocaine) patches, 1/2 on each foot is enough. You might have to tape them down too...as the adhesive is not very strong with them. But the pain relief is nice. It takes about an hour to get going, so be patient.

There's a possibility this might change in the future: Modified chilli ingredient may be a new way to relieve severe pain | Spectator Health

Capsazepine is supposed to have all the advantages of capsaicin, but none of the ill effects. Will be interesting to follow this.

Thanks, Wide-O--- that looks promising. Lidocaine works by blocking sodium channels and prevents sensory information from being transmitted to the brain.

I found out yesterday, that Aspercreme also has an OTC new version of RX Lidocaine patches... 4% instead of RX 5%.

The lidocaine really works well for me in the lotion/cream version though.

I really don't think you can get 4% in UK however except on RX.

I read that the WalMarts here have this, much less expensive than Amazon so far.

I will ask my Doc for some. My feet are killing me!

And me! I hope they find something soon to help us poor sufferers!

I would like to see more information on straight forward PN. The pain I suffer is quite serious and drives me to distraction! I am very old so I just put up with it and hope that there will be help and a cure for you all in the future.

Why of course they're naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid.

http://www.jlr.org/content/51/12/3481.short



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