[mrsD]

This was posted on General forum this morning, but it
has potential for PNers IMO....

http://news.ucdavis.edu/search/news_...lasso?id=11258

I'd like to know which "lipids" this article refers to.

[Joano]

It looks like they're concentrating on diabetic neuropathy, which I guess is much more common than for people who aren't diabetics--like me!

[janieg]

Originally Posted by mrsD

This was posted on General forum this morning, but it
has potential for PNers IMO....

http://news.ucdavis.edu/search/news_...lasso?id=11258

I'd like to know which "lipids" this article refers to.

Why of course they're naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid.

http://www.jlr.org/content/51/12/3481.short



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[janieg]

Are they basically talking about fish oil, MrsD? I'm trying to peel back the scientific jargon, and that's where I seem to have landed.

I never knew what EPA and DHA stood for!

[janieg]

Still trying to understand what they're saying, but it's difficult because when I read the scientific research reports I only understand about every fourth word.

If I try to get this is in plain English, this is what I'm gathering...

- ER Stress plays a significant role in neuropathic pain.

- ER Stress is mitigated by EPA and DHA which have an analgesic effect in the body.

- EPA and DHA are broken down by soluble epoxide hydrolas (sEH) into diols taking away their analgesic effects.

- The idea is to block sEH from breaking down EPA and DHA so they can in turn block ER Stress.


This is the UC Davis patent for "Treating Neuropathic Pain with sEH Inhibitors." Let the games begin.

http://www.google.com/patents/US20150065540



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[mrsD]

It also seems to me that providing MORE fish oil would eventually override or use up the enzyme, so perhaps until there is an inhibitor of the break down enzyme, maybe just a bit higher dose would help?

[janieg]

Originally Posted by mrsD

It also seems to me that providing MORE fish oil would eventually override or use up the enzyme, so perhaps until there is an inhibitor of the break down enzyme, maybe just a bit higher dose would help?

That's what I was wondering. It would be an expensive experiment, but I might try it.

Interesting to my situation, I've seen estrogen referred to as an "sEH suppressor" in one report (can't drum it up at the moment), but this report seems to indicate the same:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972065/

Estrogen, soluble epoxide hydrolase & cardiovascular injury

"17β-estradiol may regulate an emerging novel therapeutic target against CVD – soluble epoxide hydrolase (sEH) . Arachidonic acid is converted to endogenous lipid epoxides epoxy-eicosatrienoic acids (EETs), which sEH (the cytochrome P450 [CYP] eicosanoids-metabolizing enzyme) degrades to 1,2-diols (dihydroxy-eicosatrienoic acids [DHETs]). High sEH levels decrease EETs and increase DHETs, whereas inhibitors of sEH increase the EETs to DHETs ratio in animal models."


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[janieg]

I didn't understand a word of this.

New molecular mechanism of neuropathic pain in mice

http://www.neuroscientistnews.com/re...thic-pain-mice


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[mrsD]

That looks very promising.

Notice that in the neuropathic diagram, it shows that increased glutamate = pain.

This is why avoiding MSG is important.(monosodium glutamate)

Nice pictures too!

[DejaVu]

RE: Excitotoxins

Blocking NMDA receptors with Namenda

Namenda (memantine) is a medication with FDA approval for use in people with Alzheimers. This med acts upon the glutamatergic system by blocking NMDA receptors.

This med is also sometimes used in pain management, for chronic neuropathic pain.

This medication (like so many) has many potentially serious adverse effects, including but not limited to heart issues, nervous system issues (including potential for Tardive Dyskinesia) and many other potential complications. Please ask your pharmacist for potential adverse reactions/side-effect info.

I'd had this med prescribed for me in an attempt to quiet neuropathic pain several years ago. After a 90 day trial, I did not find this med helpful enough, in my case, to further chance the potential complications. The prescribing physician had felt I was overly concerned about the potential adverse reactions. I had kindly/gently, yet strongly, disagreed with him. I was experiencing no noticeable assistance with pain from adding this med for 90 days. Just my own experience with this med. Someone else may experience remarkable results.

Here's an article about NMDA receptor agonists' failures and successes:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534915/

Lessening Exposures to Excitotoxins

It's safer, in my opinion, to lessen exposure to excitotoxins as much as possible.
(I know MrsD also mentions this often.)

See this article for more information:

http://americannutritionassociation....ns-taste-kills

Hope this info. helps somehow.

To Our Healing!

DejaVu