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Old 05-30-2017, 06:12 PM   #1
liquidz1
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Default Nicotinamide riboside

Couldnt find much in regards to this on the forums,but anyone has taken this before?


There are also a human study been conducted at the moment for it.

Couldn't find much about its personal usage on neuropathy on the net ,just this one man who posted that hes diabetic neuropathic pain on hes feet are gone after taking it for a couple of days.Dosages seem to be high as i have been reading on some forums.

I would like to post some links but my posts are too low
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Old 06-04-2017, 07:48 AM   #2
janieg
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Deleting this post. It was made BC (Before Coffee).

I tried NIACINAMIDE, not this stuff. Oy.

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Idiopathic, Full Body, Small Fiber Neuropathy since 11/2013. Symptoms include altered sensation in toes; constant tingling/vibrations in feet and lower legs; intermittent tingling in temples, scalp and face; full body "buzzing" in the morning; referred sensation in feet cause by touch; occasional bouts with severe cramping in my feet and legs; when flaring, full body burning.

Metabolic issues: FBG -90 A1C - 5.3 with glucose spikes over 200, can't metabolize alcohol, high LDL. Genetic mutations contribute to glucose issues.

Current treatments:
  • Omega 3's - Fish Oil (2400 mg EPA, 1200mg DHA), 2000 IU D3, 200 mg Magnesium Threonate,
  • 5 mg Meribin Biotin for low-normal biotinidase levels.
  • Low carb "back to the farm" diet
  • Quell TENS unit, 5% lidocaine patches, magnesium cream

Last edited by janieg; 06-04-2017 at 05:46 PM.
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Old 06-04-2017, 08:44 AM   #3
mrsD
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Here is a link to a good overview of this product:

Whats the TRUTH about Nicotinamide Riboside (NIAGEN) | Alivebynature - Evidence Based Reviews

Only 12 people were in the study discussed. And of them the only endpoint was serum blood levels, and not metabolism changes since the study participants were "normals" and not sick.

Here is the endpoint of the article:
Quote:
However until more research is published, we don’t know if the benefits seen in studies with mice are confirmed in human testing.
Conclusion: YES, NIAGEN works at NAD+ levels. We just don’t know how much the increased NAD+ levels benefit in restoring youthful function to aging cell.
I think $60 for 60 capsules is a bit much.

I learned at a medical seminar a short while ago that rodent studies only pertain to humans about 60% of the time.

So readers here can make their own decisions. If anyone decides to try this, please keep NT in mind and post your results/progress.
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Old 06-04-2017, 03:36 PM   #4
caroline2
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A couple members on another health group I'm a member was just discussing this but I ignored it .. just don't know. I was taking Niacinamide for arthritis but stopped that when I went to the hospital/rehabs.
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Old 06-04-2017, 05:47 PM   #5
janieg
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This is not what I tried. I get no points for reading comprehension.
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Idiopathic, Full Body, Small Fiber Neuropathy since 11/2013. Symptoms include altered sensation in toes; constant tingling/vibrations in feet and lower legs; intermittent tingling in temples, scalp and face; full body "buzzing" in the morning; referred sensation in feet cause by touch; occasional bouts with severe cramping in my feet and legs; when flaring, full body burning.

Metabolic issues: FBG -90 A1C - 5.3 with glucose spikes over 200, can't metabolize alcohol, high LDL. Genetic mutations contribute to glucose issues.

Current treatments:
  • Omega 3's - Fish Oil (2400 mg EPA, 1200mg DHA), 2000 IU D3, 200 mg Magnesium Threonate,
  • 5 mg Meribin Biotin for low-normal biotinidase levels.
  • Low carb "back to the farm" diet
  • Quell TENS unit, 5% lidocaine patches, magnesium cream
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Old 06-04-2017, 07:06 PM   #6
mrsD
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Nicotinamide and niacinamide are the same thing.
The riboside makes it a different compound from niacinamide
hence a more specific product to make NADH which is the target
desired medically.
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Weezie looking at petunias 8.25.2017


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These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.
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"Thanks for this!" says:
caroline2 (06-04-2017), janieg (06-06-2017)
Old 06-04-2017, 08:38 PM   #7
kiwi33
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Adding to what mrsD cited:

" YES, NIAGEN works at NAD+ levels. We just don’t know how much the increased NAD+ levels benefit in restoring youthful function to aging cell."

This is a reference to what is called a "surrogate outcome" study. It is not a surprise that NIAGEN increases blood NAD+ because it is a biochemical precursor of NAD+. Surrogate outcome studies are often very unreliable as predictors of therapeutic benefits.

Drug companies are fond of surrogate outcome studies because they are quick and cheap to do.

Using intentionally silly words to make my point: A drug company might report "Our WonderDrug77 blocks the action of the Zogbeta4 receptor. Over-active Zogbeta4 receptor is a risk factor for Fred's Encephalopathy.". The inference that is intended to be drawn from this is that the drug is therapeutically beneficial. This does not follow.

A real equivalent of this is that many surrogate outcome studies have shown that statins decrease blood cholesterol levels. This is no surprise because statins inhibit HMGCoA reductase, which catalyses a step in cholesterol biosynthesis. It does not follow from this that statins are, with acceptably low adverse side-effects, useful in treating patients who are at increased risk of cardio-vascular disease because of elevated cholesterol levels.

The contrast with a surrogate outcome study is what is called a "real-life outcome" study. Often drug companies do not like them because they are expensive and take a long time.

A real-life outcome study poses the question "Does drug X, compared to placebo, lead to improved health outcomes with acceptably low adverse side-effects?".

Bottom line; surrogate outcome studies mean very little. Only the results of a well-designed real-life outcome study will help people to make an informed choice about whether a drug may help them.
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Last edited by kiwi33; 06-04-2017 at 09:55 PM. Reason: Clarity.
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Old 06-06-2017, 07:36 AM   #8
janieg
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Quote:
Originally Posted by mrsD View Post
Nicotinamide and niacinamide are the same thing.
The riboside makes it a different compound from niacinamide
hence a more specific product to make NADH which is the target
desired medically.
Gotcha. I purchased Now niacinamide on Amazon for something like $10.
__________________
Idiopathic, Full Body, Small Fiber Neuropathy since 11/2013. Symptoms include altered sensation in toes; constant tingling/vibrations in feet and lower legs; intermittent tingling in temples, scalp and face; full body "buzzing" in the morning; referred sensation in feet cause by touch; occasional bouts with severe cramping in my feet and legs; when flaring, full body burning.

Metabolic issues: FBG -90 A1C - 5.3 with glucose spikes over 200, can't metabolize alcohol, high LDL. Genetic mutations contribute to glucose issues.

Current treatments:
  • Omega 3's - Fish Oil (2400 mg EPA, 1200mg DHA), 2000 IU D3, 200 mg Magnesium Threonate,
  • 5 mg Meribin Biotin for low-normal biotinidase levels.
  • Low carb "back to the farm" diet
  • Quell TENS unit, 5% lidocaine patches, magnesium cream
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Old 08-15-2017, 11:27 PM   #9
tnthomas
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I have used NADH in the past, did help enhance my 'mental acuity", which was subpar after six months of Interferon and Ribavirin treatment.

I'll probably re-order NADH, just trying to use up the supplements I've bought, before getting more.
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