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-   -   Marijuana for Pain--Medscape (https://www.neurotalk.org/peripheral-neuropathy/132169-marijuana-pain-medscape.html)

LizaJane 09-08-2010 03:47 PM

Marijuana for Pain--Medscape
 
Thought this would be of interest---In California, it's available, and I think it's time has come in more states, as the budget crunches are causing states to want to stop jailing people for possession of marijuana. Too costly.


Quote:

From Medscape Medical News

Smoking Marijuana Eases Chronic Neuropathic Pain
Fran Lowry
Authors and Disclosures
Physician Rating: ( 22 Votes ) Rate This Article:





August 30, 2010 — Smoking cannabis reduces chronic neuropathic pain and also improves sleep, according to new research published today in the Canadian Medical Association Journal.

A single inhalation of 25 mg of 9.4% tetrahydrocannabinol herbal cannabis 3 times a day for 5 days was sufficient to achieve these outcomes, lead study author Mark A. Ware, MBBS, from McGill University Health Center, Montreal, Canada, told Medscape Medical News in an interview.

"Patients have been reporting that cannabis helps control their pain, and they have been saying so for a long time," Dr. Ware said. "At the time that we had secured the funding and began the trial, there had been no clinical trials that had established this or investigated it."

In addition, a large body of scientific knowledge is emerging abound the role of cannabinoid receptors and cannabinoid ligands in the human body, providing a potential scientific explanation as to why cannabinoids would be analgesic, he added. "So the 2 main supports came together, and in Canada at the time, there was an environment where we were able to secure funding sufficient for studies of this."

Posttraumatic and Postsurgical Neuropathy

The study included 21 individuals older than 18 years (mean age, 45.4 years) with posttraumatic or postsurgical neuropathic pain lasting for at least 3 months. They were randomly assigned to receive cannabis at 4 potencies — 0%, 2.5%, 6%, and 9.4% tetrahydrocannabinol — during 4 periods in a crossover design. Each period lasted 14 days and began with 5 days of cannabis use followed by a 9-day washout period.

The cannabis doses were delivered in a single smoked inhalation using a titanium pipe. Patients self-administered the first dose of each period under supervision and were instructed to inhale for 5 seconds while the cannabis was lit, hold the smoke in their lungs for 10 seconds, and then exhale. They self-administered the remaining doses for each period at home.

The participants were allowed to continue their routine medications, and the use of acetaminophen as breakthrough analgesia was also permitted.

Pain intensity was measured using an 11-item numeric rating scale that used "no pain" and "worst pain possible" as anchors.

The study found that the higher dose of cannabis was the most efficient in reducing pain. The average daily pain intensity was 5.4 with the 9.4% tetrahydrocannabinol cannabis dose compared with 6.1 with the 0% or placebo dose (95% confidence interval, 0.02 – 1.4; P = .023).

In addition, participants reported significantly more drowsiness and reported getting to sleep more easily, faster, and with fewer periods of wakefulness when taking the 9.4% dose than when taking the 0% dose (P < .05). The higher dose also improved anxiety and depression compared with the placebo dose.

Blind Held; Studies Feasible

"It was feared that participants would know right away if they were smoking cannabis because of the acute psychoactive effects of the drug, but our results do not support this," Dr. Ware noted. "They do show that short-term placebo-controlled trials of smoked cannabis are feasible."

He would like his study to act as a stimulus for other studies on cannabis and pain relief.

"Studies of this kind can be done. Ours was difficult to do because it was the first time we had done anything like this. We were breaking new ground with regard to regulations and so on, but it is possible. Having done it once, it's not as difficult to do it again. So our results raise the possibility of extending the study for a longer duration, or being able to look at safety issues, and so on. It is possible to do a scientific trial with this compound. Your political views shouldn't matter. This is just good science," Dr. Ware said.

In a related commentary, Henry J. McQuay, DM, from Balliol College, Oxford, United Kingdom, writes that the study authors should be congratulated for tackling the question of whether cannabis helps in neuropathic pain, "particularly given that the regulatory hurdles for their trial must have been a nightmare."

He concludes that the study "adds to the trickle of evidence that cannabis may help some of the patients who are struggling at present."

Dr. Ware has disclosed no relevant financial relationships. Dr. McQuay reports financial relationships with Reckitt Benckiser, Pfizer Data Safety and Monitoring Board, Archimedes, Esteve, Sanofi, Ratiopharm, Sandoz, and Grunenthal. He has received royalties for a textbook on the subject of pain.

CMAJ. Published online August 30, 2010.
http://www.cmaj.ca/cgi/rapidpdf/cmaj...urcetype=HWCIT

cyclelops 09-08-2010 04:48 PM

The pox on cannabis needs to end.

What the heck...isn't morphine derived from the plant...at least the natural stuff?

OK, so here is an idea....grow marijuana for hemp....hemp, a natural product we could make all kinds of things with and use less plastic....and also, get pain relief from the plant too....or a variety there of. Seems like a gift from the gods.

I live in the conservative Midwest, outside of a bastion of liberality. Back in the '90s, I remember all of a sudden, having dozens of military vehicles, cops etc, parked across from my home.....my lord, :Hum: I thought it was an invasion. :yikes: Cripes, I didn't know if I should grab a pack and run for my life....smoke billowing form the fields across the road....black helicopters....

Well, apparently there was a field there, of MJ, left over from WWII when they grew it for naval ropes?? Honestly. This sweet smoke that drifted over the house resulted in a large binge eating at supper that night.:eek: I distinctly remember how funny everything seemed to me and the kids.

Ladysheets 09-09-2010 12:06 AM

I was raised in the midwest so i do know what your saying:rolleyes:

I live in alaska now and everyone seems so much more open minded.

I have used MJ and it does help the neuropathic pain, i dont see why it would be so much worse than Neurontin or amatriptyline. It sure makes me feel a heck of a lot better than they do:ROTFLMAO:

zorro1 09-09-2010 06:37 AM

Quote:

Originally Posted by LizaJane (Post 693126)
Thought this would be of interest---In California, it's available, and I think it's time has come in more states, as the budget crunches are causing states to want to stop jailing people for possession of marijuana. Too costly.




http://www.cmaj.ca/cgi/rapidpdf/cmaj...urcetype=HWCIT

"It was feared that participants would know right away if they were smoking cannabis because of the acute psychoactive effects of the drug, but our results do not support this," Dr. Ware noted. "They do show that short-term placebo-controlled trials of smoked cannabis are feasible."

errmmmm :eek:

Marlene 10-12-2011 02:15 PM

Clearing the smoke
 
PBS documentary on Medical Cannabis.

http://watch.montanapbs.org/video/1825223761/

surfer00 10-16-2011 11:49 AM

I smoke MJ for PN each night around 8 pm. My pain goes down anywhere from 80-100% and I sleep all night long. I live in California and have a Drs. recommendation, but I would use it even if it was illegal. I dont want to take ANY prescription painkillers.

BTW, I wake up refreshed everydat, withour the dreaded 'prescription hangover' Ive experienced with other drugs.

jannaw 10-17-2011 06:45 PM

Cannabis is legal here in Montana although reforms came this year after ten thousand citizens became "card holders" and it was found 80% of them were between 20-30. It is still legal but no more Doctor Mill clinics and more reporting in must be done, it was fun for some while it lasted! I personnally wish it were legalized and dispensed by the state and taxed a bit, its not for me but my sister in law couldn't function without it. I will never say never either, there may come a day when it is my last option. For those in unbearable pain if it works by all means use it, I found myself drifting over here after laying down to nap and finding my feet decided to feel as if they were frying in a vat the moment I laid down. Happens every time unless I'm drugged for bedtime, blasted disease/condition anyhow!

surfer00 10-18-2011 12:38 PM

Jannaw

Why don't you use it? When my feet burn, it usually stops it immedately.

nsw43 10-20-2011 12:10 AM

There's a cannabis-based pharmaceutical called Sativex that's approved in the UK, Canada and some other countries for use in MS spasticity and neuropathic pain. It's in a Phase III trial in the US, and I've been hoping it will get approved here but so far it hasn't.

The good thing about having something like Sativex is the THC is pure and metered so you get the same dose every time. Also it's dispensed as a mist and absorbed sublingually, which is nice for those of us who have a hard time smoking.

Here's a link for more information: http://www.gwpharm.com/Sativex.aspx

hopeful 10-20-2011 04:38 PM

Quote:

Originally Posted by nsw43 (Post 816561)
There's a cannabis-based pharmaceutical called Sativex that's approved in the UK, Canada and some other countries for use in MS spasticity and neuropathic pain. It's in a Phase III trial in the US, and I've been hoping it will get approved here but so far it hasn't.

The good thing about having something like Sativex is the THC is pure and metered so you get the same dose every time. Also it's dispensed as a mist and absorbed sublingually, which is nice for those of us who have a hard time smoking.

Here's a link for more information: http://www.gwpharm.com/Sativex.aspx

This sounds like something I would try. I don't like the idea of smoking. I wish I could try cannabis. I work in a school so I won't try it until it is legal.hopeful

melon 10-20-2011 04:38 PM

Quote:

Originally Posted by nsw43 (Post 816561)
There's a cannabis-based pharmaceutical called Sativex that's approved in the UK, Canada and some other countries for use in MS spasticity and neuropathic pain. It's in a Phase III trial in the US, and I've been hoping it will get approved here but so far it hasn't.

The good thing about having something like Sativex is the THC is pure and metered so you get the same dose every time. Also it's dispensed as a mist and absorbed sublingually, which is nice for those of us who have a hard time smoking.

Here's a link for more information: http://www.gwpharm.com/Sativex.aspx

Yes, but from what I hear you can only possibly get it privately here in the UK , or with Insurance ( its not cheap )

See for yourself

The NHS refusing cancer patients drugs, so what hope do I have ? :(

m

melon 10-20-2011 05:14 PM

Strange - I dont see my last post .

There is another pill too here for any one interested - I have no idea what the price is , but I can tell you the Sativex costs £480 here in the uk - not cheap !

tepol

hopeful 10-20-2011 06:03 PM

Quote:

Originally Posted by melon (Post 816755)
Yes, but from what I hear you can only possibly get it privately here in the UK , or with Insurance ( its not cheap )

See for yourself

The NHS refusing cancer patients drugs, so what hope do I have ? :(

m

Way too expensive for me! hopeful

melon 10-20-2011 06:29 PM

Quote:

Originally Posted by hopeful (Post 816800)
Way too expensive for me! hopeful

Your not alone...

Its worse I have so many other issues that keep jerking me around , to ever know which way to turn.

Ive been disabled and housebond now for year as result , and probably should of taken up indoor gardening .

The argument against drugs as someone who used them for " spiritual purposes " really gets under my skin, alcohol far exceeds it for related deaths - yet if anything is advertised and freely sold too much.

Once again drink sells, esp when mixed with hormones , and 1 % get rich.

melon

malawigirl08 10-20-2011 07:26 PM

Quote:

Originally Posted by melon (Post 816805)
Your not alone...

Its worse I have so many other issues that keep jerking me around , to ever know which way to turn.

Ive been disabled and housebond now for year as result , and probably should of taken up indoor gardening .

The argument against drugs as someone who used them for " spiritual purposes " really gets under my skin, alcohol far exceeds it for related deaths - yet if anything is advertised and freely sold too much.

Once again drink sells, esp when mixed with hormones , and 1 % get rich.

melon

you are so right Melon, it is so unfair. Our NHS is ruined and the people who need it most are wasting away on lists, but hey ho the bosses are meeting their targets so that's ok.
Everything always comes down to cost, and as you say alcohol makes money!
Sorry for the rant

melon 10-20-2011 08:15 PM

Quote:

Originally Posted by malawigirl08 (Post 816817)
you are so right Melon, it is so unfair. Our NHS is ruined and the people who need it most are wasting away on lists, but hey ho the bosses are meeting their targets so that's ok.
Everything always comes down to cost, and as you say alcohol makes money!
Sorry for the rant

Well thos NICE guidelines ( talk about taking the pi** ) certainly make for interesting reading about what is and is not and how much of what applies to whatever they want.

The problem is that the average person is like cattle, you can milk them for all its worth but as long as they get their basic requirements of sex , booze ,gossip,fashion, sport ( soccer here usually ) tv and their carryouts their as happy as lala.

So the majority are just clueless.. and the ones that arent are labelled as kooks, anti social or whatever for the same reason they've typecast and lumped all drugs users as bad evil people and smokers now as satan himself.

People dont change unless their forced too , but unfortunately that wont happen unless something else forces to first.

This is probably one of my favourite links , its literal field guide on the typical approach used by the NHS doctor, Id defy any one here who has not at least experinced more than one of these examples during their troubles.


peace

melon

melon 10-20-2011 08:36 PM

Quote:

Originally Posted by malawigirl08 (Post 816817)
you are so right Melon, it is so unfair. Our NHS is ruined and the people who need it most are wasting away on lists, but hey ho the bosses are meeting their targets so that's ok.
Everything always comes down to cost, and as you say alcohol makes money!
Sorry for the rant

Its not even the case where it just money but sciencism from the scientists themselves that ensures the rhetoric thinking and same old egos are satisfied at the expense of progress, and culture of fear , peer pressure ( based on their own needs ) rather than discovery or progress comes first.

The Apple as it were is rotten right through to the core .

How easily they forget, or rather choose to forget history.


melon


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