? for Ms.D:Pain from food even w/ normal bs.
 

I'd really like to know why my feet will hurt after eating even though my blood sugar numbers are perfect at the time.

Some foods are histamine releasers. Tomatoes for example.

http://foodallergies.about.com/od/co...amineintol.htm

and list:
http://www.urticaria.thunderworksinc...htm#foodsource

I find that potatoes make my feet burn! I found this out 3 yrs ago. The nightshade family of veggies is hard to tolerate for some people. They also contain solanine, beside the histamine problem.

Also depending on what you ate ... if there is sugar or starchy carbs in that meal, you can get increased burning or other foot symptoms. Sugar spikes insulin and high insulin stimulates PGE2 cytokines which dilate blood vessels.

A high sugar + fat intake such as ice cream, will increase the viscosity of the blood, and reduce circulation in the tiny vessels of the hands and feet, and induce pain sensations in those with high protein levels in the blood. (MGUS). High fat meals have shown in normal volunteers in studies to be very damaging by increasing the viscosity of the blood for HOURS.

People can have impaired glucose tolerance for years, as insulin resistance and still present with "normal" fasting morning glucose tests. But this condition is already leading to PN.

http://www.citeulike.org/user/wrs1/article/6499468

Makes sense. Thank you ever so much for your reply since I have been searching for some explanation for years. God bless you for the wonderful important job you do!

Question for Mrs. D;

I do have an IGG MGUS (0.6 level) and thus if I am potentially getting increased blood viscosity then would the 162 mg of aspirin that I take daily compensate for that?

Also, in talking with the Myeloma Institute they indicated that a MGUS IGG level of 0.6 would be too low to be causing any increased blood viscosity.

Thoughts and thank you?

Might not be too low--
 

--to cause neuropathy, though.

MGUS is definitely a cause of neuropathy, and often at lower levels than would be a concern for blood cancers--there is often antibody cross reactivity to components of peripheral nerve.

See:

http://neuromuscular.wustl.edu/antibody/mprotein.htm

http://www.neuropathy.org/site/DocSe...pdf?docID=1061

Have you had a uric acid level done. Gouty arthitis in any joint can be aggravated by certain foods with purines.

Aspirin only affects platelets... clotting.

It cannot prevent the proteins from increasing the viscosity of the serum. The aspirin may prevent a blood clot from forming, however.

I think just avoiding high fat meals, and staying well hydrated is all you can do at this point for MGUS.

It is possible that cold laser helps with the circulation in the feet and hands. I saw a paper once from Europe, that said the light denatures some of the peptides. But I don't know if that has real proof behind it yet.

I have studied MGUS extensively and can report the following regarding MGUS and neuropathy. It has been shown that approximately one in ten neuropathy sufferers also had MGUS (IGG, IGM, or IGA). Of that 10%, only three in ten had an IGG MGUS.

That puts the odds of my IGG MGUS being the cause of my small fiber neuropathy at only 3% or so. While not impossible, I think that with only a 3% chance I am not putting much focus on MGUS as the cause.

Thoughts?

.... are there any truly accurate tests to see if your blood viscosity is actually elevated?

I don't know. But with cryoglobulins, as the peptides will precipitate out and block the vessels entirely, in cold conditions.

You can look up cryoglobulinemia, on Google to further understand this variant.

.... I don't understand what you are saying above. Also, if there are no tests for blood viscosity then how do we even know that it is even a factor?

One can test for the globulins. When they are there the viscosity will be higher by definition.

If one has the cryo ones cold will cause pain and sudden increase of symptoms.