Is there evidence that RSD is gentic or linked to blood groupe
 

Hi to everone,
Im AB positive blood groupe, which is a bit unuseual,i was wondering if RSD was linked to blood groupe
Or could it be genetic?
Is there any research in this area?

Would be interested to know

Flora99

Well....

I'm not sure on the research tbh, but a lot of scientists have admitted that there's very little high quality research being done into CRPS, so it's difficult to know. There are hints at all sorts of links including genetic, but just because it hasn't been properly looked at yet doesn't mean much. I was reading a paper the other day that mentioned that there was some evidence to suggest a genetic link, and a predisposition to developing CRPS in the children of a parent suffering the disease.

My father has neurological problems in his feet (he had surgery as a young man) which have been getting worse with age. He has had nerve conduction studies that showed his nerves are nor working as they should - however, it is not CRPS (he mentioned to his neurologist about me having it), but his doc was interested that both he and I have persistent neuro issues that are resistant to treatment or pain meds, and admitted it might not be a complete coincidence (he'll have to be careful talking loose like that, he could be struck off :rolleyes:).

So yes, if I'm honest I think there's a fair chance of a genetic component that puts us at greater risk of developing it. I have coeliac disease, another auto-immune condition, and that's been proven to be genetic - so one of my parents has it (we're not sure which, probably my dad again lol - he won't be tested). As CRPS seems to be auto-immune as well, maybe there is that link as well...

Oh yes, and I am O-negative, which is rare-ish too.

Anyhow...just my opinions ;)

Bram.

http://www.londonpainclinic.com/comp...pain-syndrome/

There is a lot of evidence-based papers and discussion about CRPS on this site. Well worth a few hours of light reading :D

Bram.

Thats really interesing Brambledog.,that your blood groupe is unusual too!
I wonder if there is a high proportion of people with an unusual blood groupe?
Thankyou for telling me about the link with your father.I didnt know RSD was thought to be an autoimmune thing.
I dont know my fathers full medical history as i was adopted.
Thankyou for your interesting reply.
Big Hug
X

Thankyou i will certainly will have a look .
My physio who origonally spotted what i had knew a lot as he had had a mild case of RSD from having whiplash himself.He passed on a lot of what he knew to me,so i understood more than than most after my diagnosis,but that was 10 years ago,and i hope there is more to learn now,especially from other members,as RSD is diferent for everone.

The only study was done by the dutch.
http://rsds.org/2/library/article_ar...turkenboom.pdf

The 2 besty resources fo collected papers I've found are
http://www.thblack.com/links/RSD/index.html
there is a dutch one cotaining every paper ever published there but can't find the link at the moment

I'm O Positive. Which is 1 of the most common blood groups.

Very interesting!

I am also O positive. I come from a large family (number 7 of 8 kids). No one else in my family has gluten problems or rsd related issues. Nothing neurologic, except migraines, and some with a few allergies and arthritis. It appears that I got the bucket load of problems :(

I read somewhere not too long ago that adults with it can have children with it. They try to say the parent has munchausen (I think is how its spelled) and is passing it off or making a bigger deal of a childs growing pains. It was in a crps research thing from a conference for children with rsd. Don't ask me how I got there for adult onset lol.

Lol Nanc, I feel the same! :rolleyes:

I personally don't see how blood group can have anything to do with it, but I do think genetics could play a part. Just because you or any member of your family carry a gene, doesn't mean that that gene becomes dominant and you suffer symptoms. The reason that some of us develop a condition because of the gene we carry, and some don't, is the interesting possible research for me.

Bram.

Thats too true Bram. My maternal Grandmother and all 3 of her daughters had breast cancer but none of the grand or great grand children have had it. A gene doesn't become active until something triggers it. None of my family have rsd except me. We do have some with celliacs, lupus and 1 with ms but none with rsd.

I think I've only heard of one case where the mother and daughter have RSD. No one in my wife's family has RSD except my wife. None in my family at all. The only links I see are possible age groups-mostly female, and it seems more European decent than any other race (this could be incorrect) I don't think blood groups have anything to do with it.

Could people with RSD have common allergic reactions before being infected with RSD? For example, my wife is allergic to penicillin. Was anyone allergic to anything before your onset of RSD?

I'm a coeliac so I'm allergic to gluten. Other than that I'm fairly normal lol :D

Bram.

I have no allergies.

My pet theory is that perhaps CRPS/RSD is more likely when the injury/surgery takes place during a particularly stressful time (by this I mean, stress apart from the precipitating injury/surgery). My understanding it the disease first began to be identified in soldiers in the American Civil War and I think it is still being seen in combat troops.

Of course, that is just my personal pet theory with no real foundation. Pure speculation.

Kim,

That is more likely very true in RSD/CRPS instead of the type that was found during the Civil War times inflicting soldiers. This type is the CRPS II/Causalgia which occurs after major nerve injury such as from shrapnel, gun shot wounds, surgery, amputation etc., not saying there isn't stress during war times more or less saying that in that 'type' of CRPS there is a known cause or inciting event.

I think in either type, stress could be a factor. Of course, I have no idea. It isn't as if there is much research on which to base any theories...not that I have any scientific qualification anyway.

No one in my family, as large as it is, has RSD either.

I was diagnosed with RSD in 1991. I had allergies when younger, but nothing major. I developed more severe allergies in 1996, environmental and foods. Foods I never had a problem with and all the sudden my throat is closing...it was crazy. It has only gotten worse over the years. My husband jokes around saying I am allergic to everything but him...I told him to give it time...haha!

In my case, stress was not a factor. It was a happy time for me when it first happened. The stress began after I was diagnosed.

It is a great theory but if stress was a major factor it would seem that more people would end up with it after surgery; since I don't know anyone who isn't stressed going into surgery and some way more than others. Or why would it then occur to so many people after just having a simple blood draw or finger stick which shouldn't be as stressful as say surgery?

Phantom limb pain is another area that affects some and not others, sometimes it temporary and sometimes it is permanent even though the severing of the nerves should render the same outcome.

Sure wish the answers were easy..

To be clear, I did say it was pure speculation and just a pet theory. I am not under the impression that it is the answer.

You could be absolutely correct. I've heard this many many times. My wife was stressed a couple of times during her broken wrist nightmare. For one she is shy, we were out of town visiting my family, she worked at a very stressful Benefit division for a large business. When she broke her arm, she had it set at a hospital in NJ. They wanted her to stay the night, she refused. They warned her her arm may not be set correctly and wanted to make sure it was. She decided to wait and have it looked at in DC. One month later she had to have the wrist rebroke and set. She made another bad decision by refusing to be admitted into the hospital, sedated for the arm to be reset. She wanted the arm redone in the docs office using local anesthetic. And the nightmare really started. She never liked doctors, hospitals of any sort and has been extremely difficult for her to then have to deal with multible doctors etc. Very stressful for her.

I understood that you were speculating :) I have heard that theory many times before too.

My pm dr didn't want to manipulate my wrist and fingers after it was set wrong the first time. He was afraid the rsd might spread. My orthopedic dr agreed. I was given nerveblocks, pt and prednisone instead, but I still can't bend my wrist and I can only bend and straighten my fingers half way. They are also twisted to the right and my wrist is lined up crooked, as visible to the naked eye. I couldn't straighten my arm either until I did pt, my elbow was locked. Now I can bend my elbow though. And my shoulder does not allow my arm to bend back all the way.

Here's a read that I received on facebook from the RSDSA. It touches on the subject of this thread. If the read is too long check out the last paragraph.

"Why Does Chronic Pain Hurt Some People More?
Brain Research Reveals New Clues
Brain research reveals new clues about the reasons behind different physical reactions among those who suffer injuries.

By Shirley S. Wang

Why does pain from the same type of injury linger in some people but not others?

Genetics and brain-based biological factors are the latest frontier of research on chronic pain, along with personality traits, coping strategies and life experiences. The question is a riddle researchers have been trying to solve for decades.

*edit*
sorry there is copyright on original article (http://online.wsj.com/article/SB1000...wsj_india_main)

This part:
"Dr. Apkarian’s group also looked, in a previous study published last year, at anatomical changes in the brain’s gray matter, which helps control sensory perception, muscles and emotion. That investigation found that chronic pain appeared to reorganize brain structure. They found unusually high levels of communication between two regions, the prefrontal cortex and nucleus accumbens.

“The more they talk to each other, the more likely someone is going to become a chronic pain patient,” Dr. Apkarian says."

I wonder about that. I've always been very sensitive to touch.

My dad does have some issues, he gets seizures. He's currently going through the VA to get benefits for the Agent Orange toxins that he got when in Vietnam.