Hyperbaric oxygen treatment - beneficial for PCS?
 

I'm seeing a psychologist who specializes in brain injury, and he suggested that if I'm interested in pursuing alternative treatments, that I look into HBOT. Back when I could read/spend more time on computers, I remember finding an article that suggested that HBOT could help TBI if treatment started relatively quickly after the injury, but I didn't find a lot (granted I wasn't really looking too hard) suggesting that it could help someone well after the initial injury.

Does anyone know more about this, or had experience with it? Has it been shown to be helpful for PCS, even well after the injury? I've found a place that's close to my house, and while it's obviously expensive, I'd be willing to dip into my savings if there's a reasonable chance it could be helpful.

a lot of ongoing tests in the military right now. results mixed. we had a guy on the board who tried it in mexico and he wasn't too impressed with the results if I remember right but he was paying so little it was worth it. a few others will com along I'm sure with more info. we had another guy going for that shot in florida, I think, but we haven't heard back from him yet

I think that someone was going down to Mexico for this... but can't remember who.. sorry

The studies show that it takes 40 to 80 treatments to see a noticeable improvement if there is an improvement. The HBOT industry has been promoting HBOT for PCS due to anecdotal evidence. Some are trying to do valid clinical studies but a true double blind study would be a challenge.

Mark, the military is doing a number of hbot studies. Will these be double blind automatically or not necessarily so? I'm not even sure what double blind means.

Just found a nice review article (Hyperbaric oxygen therapy for chronic post-concussive syndrome) that talks about the challenges in doing a truly blind study (hard to fake a true hyperbaric chamber experience), but it did cite a recent study published in PloS One that attempted to do this via a crossover approach that allows intra and inter group comparisons between treatment and a sort of control that I don't quite understand. This study found significant improvement in all sorts of measures after treatment, and no significant improvement after their control.

The review article says this is a promising start, but it's still not a true blind clinical trial. I'm also wondering how sustainable or lasting any improvements are after the treatment. If it provides a temporary boost, great, but not really worth the money. If the treatment actually leads to lasting healing, then it might be worth it.

I'll have to do more research later, too much screen time!

Double blind means neither the subject nor the assessor knows whether that subject had the control (placebo or such) treatment or the studied treatment. In HBOT, the subject would have to be put in the HBOT chamber with the pressure increased but the oxygen level left at a normal ratio for the control group. (even this would not be true double blind) Then, the subjects would be studied for any changes before the data is collated by whether or not the data is for a control group subject or a studied treatment group subject using random identifiers. This removes any bias or other influence that may skew the results.

The studies so far have focused on MRI images that show an increase in capillary growth in those who have had HBOT. They extrapolate this to say that capillary growth signifies neurogenesis or such.

What is not discussed is whether these 40 to 80 sessions have an impact on healing due to the need to lay relaxed for these scheduled period of times. Meditation claims to have similar effects on capillary growth. Or whether there is a placebo effect.

thanks for sharing...did it say how many sessions brought about the significant improvement? and how significant?

I think this is the article Laupala is referring to.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984490/

If you read the whole article, including the part about placebo effect and attempts at double blind study, the result is not as rosy as first presented.

The study with the rosy results is abstracted here.
http://www.ncbi.nlm.nih.gov/pubmed/24260334

The full article is available to everyone here (hooray open access publishing!)

http://www.plosone.org/article/info%...l.pone.0079995

The review article mark posted does a good job of tempering the conclusions about the PLoS One article, while maintaining that it's a promising avenue for future research. I still haven't gotten around to closely reading the PLoS One article, a busy day!

The gist of the full report on general cognitive scores is the crossover group have negligible improvements during the control period then went from 88 to 94 after the HBOT. The treated group started at a lower baseline of 86 and improved to 96 after the HBOT.

thank mark. that saved me 2 hr round trip and mountains of debt :)

of course, if anyone finds more promising results, let me know. meanwhile, i'm getting ready for an expensive placebo treatment next friday by a neuro-chiro

information on military tests show no improvement from HBOT compared to sham group

http://journals.lww.com/headtraumare...sistent.2.aspx

Tried it at the beginning of my concussion. After 3 times it did nothing for me so I discontinued the therapy - maybe I was hoping for too much too soon - but as stated it is very expensive - if I had seen even a little bit of improvements I would have stayed with it even with the high cost.
Sorry I could not give a better report.
GB