Originally Posted by en bloc (Post 1130029)

Welcome!



YES, neuropathy can certainly come on suddenly and spread to full body in a short period of time. It's this rapid onset that usually points doctors in particular directions. Diabetes is usually a slow onset, so not surprised this has been ruled out. The two things that come to mind with rapid onset is toxic neuropathy (many antibiotics can cause this) and autoimmune process. Of course, trauma would cause rapid onset, but you don't mention any injuries.



Have you taken any antibiotics lately? If so, which ones? Have you taken anything else new (Rx or otherwise)?



Do you have any other symptoms that may be autoimmune in nature? These would include, rashes (on the face or elsewhere), profound fatigue, weakness, joint pain, dry mouth/eyes, GI problems. Any symptoms that are out of the ordinary for you (sometimes it's little things like this that help provide answers)?



The EMG is an appropriate next step. But more labs for autoimmune disorders would be a good idea.

Originally Posted by UTGrad (Post 1130030)

No injuries and nothing out of the ordinary. I don't believe my lab points to any autoimmune stuff but maybe more labs need to be taken?

One thing I should note I still run 4 miles a day with this so it must be sensory at this point. Hope it's something temporary.

Originally Posted by Neuroproblem (Post 1130045)

I think the "neuropathy " could be from you running 4miles a day, typically people should rest between runs, a few days in between, to give your body time to recover from the run. Running everyday(at that amount) can cause damage to your body. Exercising everyday(like doing crosffit) all the time damages your skeletal, and musculature of your body. No doubt it has an effect on your nerves. To gain benfit from an exercise or run, you should have a few days of recuperation, running everday can negatively affect your ability to exercise in the future. Ive seen an episode that a mother(i think) who was addicted to exercising at least 6 or more hours on the treadmill, she was skinny, with only skin and bones, eventhough she exercise. exercising causes "micro trauma to your skin" and it builds up and you become more efficient at using the muscle. eventually running everyday requires so much energy, and repairing, your muscle or other parts of your body has to shut down to keep up with the demands.

You should also look into autoimmune causes as well, is there a history of autoimmune disorders, vitamin deficiencies(are common amongst people who workout or exercise alot). Try suggesting blood test for those. You should also try to get some sort of scan done, like MRI,CAT, or ct scan to check for structural abnormalities, if its possible. Just lay off the exercise as well.

Originally Posted by UTGrad (Post 1130048)

Interesting...I've wondered if my excessive running kicked this off.

Originally Posted by Electron (Post 1130053)

Personally I am very skeptical that this could be the cause. I have never heard of excessive exercise causing PN. Maybe it could contribute in some way, I just don't think it's likely. If you want to test it, just run less. I agree that toxicity and autoimmune attack sound reasonable, but there are many other causes. You are not around any toxins where you work, medications, scraping lead paint, etc.?

Ron

Originally Posted by mrsD (Post 1130084)

Well, we do age, and with age comes changes in metabolism.



I have a few questions UTGrad...



1) when you have the tingling etc, is it all the time, or only when you run, or say are hungry? Does it go away with food consumed?



2) do you smoke and/or drink alcohol?



3) what is your diet like? Running puts a huge load on magnesium and B6. Most Americans do not consume enough magnesium daily to match the RDA for it. Magnesium is involved in the actions for energy production in the mitochondria.



4) I do think there is a possibility for you that your exercise regimen has reached some upper limit of tolerability. People all vary in how they can sustain stressful exercise, and as we age the mitochondria may be aging too. We have had younger PNers here who were pushing their limits. One fellow had extreme pain in his palms and wrists, and we finally found it was due to his pushups. He stopped them for a long period and his pain stopped. Pain is a warning sign, and running in the presence of nerve symptoms is not a good idea. Could you walk instead, and cut down from 4 miles walking to one?



5) a good thorough evaluation with Xrays of your feet might be in order at a podiatrist. Too tight of lacing of your shoes can compress the nerves in your instep and create compression symptoms, which may linger throughout the day do to the repeated daily running.



6) do you take supplements? Energy drinks, nutrition bars? Many cereals today are fortified with B vitamins. If you take supplements and took them the day of your blood work, the B12 and B6 would show a false elevation. If so 500pg/ml for B12 as a false elevation is not a good result. The B6 may be also due to consumption of B6 that you didn't pay attention to. It is also not a common test, and the labs may have used old calibration material and the test may be inaccurate as a result. The ranges used by labs were made from volunteers who were NOT using vitamins or fortified foods at the time of the testing.

Originally Posted by jurgen975 (Post 1130176)

How high is the b6 in that multivatamine your taking?



http://www.ncbi.nlm.nih.gov/pubmed/16320661