Originally Posted by mrsD (Post 1130206)

Get your spine evaluated for disc herniations, or other pathologies. And also see if you have some prostatitis...as this can happen at any age for a man.

Originally Posted by Healthgirl (Post 1130211)

Mine all started on the left side and I was convinced it was my spine. Ive been told by 3 neurologists and 2 spinal surgeons that it isn't. You still have a lot of tests to undergo though... Complete spine and brain MRI will probably follow the EMG.

Originally Posted by echoes long ago (Post 1130255)

there are blood test panels for paraneoplastic cancers that also cause peripheral neuropathy.

Originally Posted by mrsD (Post 1130405)

The typical cancer triggers are lung cancer and some bone marrow ones. For females, ovarian is often tested for.



If your avatar is indicative of your age, I'd say it would be a rare thing to have for you. Not impossible, but not one of the first things to look for.



I think you should get the DNA test for MTHFR mutations.

This is more common and up to 30% of people can have it.

Poor methylation means B12 and folic acid are not activated in the body, so nerves suffer. Poor B12 functions are often mistaken for MS in the beginning of diagnosis.



Next most common is gluten intolerance.

Also exposures to vaccines, and certain food intolerances like gluten intolerance. Some people with gluten intolerance show MS like nerve symptoms.



Exposure to certain antibiotics in the past -- fluoroquinolones and Flagyl/Tinadmax also cause nerve damage.



Look at whatever you are doing when symptoms occurred. And try to change your lifestyle away from that. If it is overuse exercise, minimize that factor. If it is dietary, remove suspected intolerances with an elimination diet. Avoid exposures to chemicals. Avoid alcohol and smoking... smoking contains many toxins and also in males affects the circulation. (peripheral artery disease called PAD)



Look to the more common and obvious... the paraneoplastic area is one to look at last.

Originally Posted by Susanne C. (Post 1130409)

Would walking relieve the symptoms as well as running does? Running may be overdoing it. I have a sensory motor neuropathy that is pretty advanced but walking on soft trails does relieve some of the pain. Are you running on a hard surface?
It is very common for neuropathy symptoms to get worse in the evening.
Also, about caffeine, I find that it helps me rather than hurts but everyone is different.

Originally Posted by UTGrad (Post 1130418)

Wow!! Great post...golf clap

Originally Posted by Neuroproblem (Post 1130444)

Based on your last post, it was recommended you go see your doctor for an MRI, at 34 you should have insurance that can cover this expenses. One of the possible causes of your neuropathy, was that you run 4mile per day, And exercising that much, and running is ultimately damaging to the body, especially the bone, muscle,nerves. Running everyday, doesnt allow your body to regenerate so you will eventually obtain complications from those issues.

paraneoplastic syndromes are different depending on what type of cancer you have. of cancer usually have other symptoms, but this is best done with an oncologist/hematologists.

Originally Posted by Susanne C. (Post 1130464)

Sorry, mine is hereditary, CMT type 2, axonal degeneration. I repeat it so often i figure everyone gets tired of hearing it.
It is incredibly frustrating, but Mrs. D.'s advice is spot on. Many people never get a clear diagnosis. Lots of cases remain idiopathic, progressive, and untreatable. The push in the early days is to find out if your symptoms have a definite cause and treatment plan, the earlier the better the prognosis if you are one of the lucky ones.

Originally Posted by xrox (Post 1130477)

Susanne, is your CMT type giving you issues with muscles as well as nerves? Since my issues seem to be with sensitive nerves (carpal and tarsal tunnel with widespread tinel sign) I wonder if I have HNPP.

http://ghr.nlm.nih.gov/condition/her...essure-palsies

Originally Posted by Susanne C. (Post 1130495)

Yes, I have extensive muscle atrophy, with limited range of motion in arms and legs, completely unable to move toes, barely able to move ankles, and progressing. Neuro at Johns Hopkins suspected HNPP as well and I had the test done for it as he found pinched nerves everywhere he checked with EMG, but test was negative. Simple but expensive blood test will tell you.

Originally Posted by en bloc (Post 1130499)

I may be wrong, but I don't see cancer or even B12 causes for 'sudden' PN. these seem to be more slowly progressing types.



You indicated in another thread that you haven't had an injury, so compression is likely out of the question and no antibiotics or other medications, so toxic shouldn't be a problem either. I'm still thinking you should be worked up for autoimmune more than cancer testing. Immune mediated PN is typically rapid onset like you've presented with. Have they done any work up for you in this regard?



Do you have any family history of autoimmune disorders?

Originally Posted by UTGrad (Post 1130500)

No family history of autoimmune that I'm aware of. My primary care doc possibly with some communique from the neuro believe it's an immune response possibly from an infection.

Originally Posted by Neuroproblem (Post 1130523)

Most autoimmune are not heridatary, mostly environment. only a select few autoimmunes are known to be heriditary. excessive running, also can cause neuropathy, and can trigger autoimmune diseases as well.

Originally Posted by xrox (Post 1130497)

I don't have any weakness or atrophy yet. When did you first notice the muscle weakness/atrophy as a symptom? Is there a chance the progression will slow/stop?

Originally Posted by Susanne C. (Post 1130541)

Do you have reason to believe that yours is a hereditary neuropathy? I do not want to worry you unnecessarily, my sitution is more severe than many, I had poor balance and coordination as a child, was never able to run well or without falling, and only learned to ride a bike with great difficulty. So the muscle weakness has always been present, as have the tight Achilles' tendons. The numbness began in my early 30's. The progression of CMT is highly variable but it always progresses. I have been on a fast track of deterioration lately, but I am 53.
This doesn't come on quickly as a rule, usually even if a diagnosis is made later in life you can see that the signs were there all along. Neuropathies that come up quickly are often the ones that can be halted or reversed if a cause can be found.

Originally Posted by UTGrad (Post 1130527)

Do you have any links or medical claims to back up excessive running causes neuropathy and autoimmune diseases?

Originally Posted by xrox (Post 1130562)

No history in my family but the HNPP description is the only one I've read that fits my symptoms of widespread nerve sensitivity. If I lightly scratch my wrists or elbow or bicep I get tingling and electric shocks in my palms and fingers. Same goes for my feet and ankles.

I have a constant burning in both wrists and ankles as well.

Have you looked into stem cell treatment or is that just a scam? Claims sound a little fishy to me.