NTCELL® Clinical Study in Parkinson’s Meets Endpoints
 

NTCELL® Clinical Study in Parkinson’s Meets Endpoints

Living Cell Technologies Advancing Regenerative Cell Therapy into Larger Phase IIb Study to Evaluate Its Potential as a Disease-modifying Treatment
Company to Host Conference Call on Thursday 18 June at 8:30 a.m. AEST / 10:30 a.m. NZT

The Phase I/IIa clinical study of NTCELL®, conducted in four patients in New Zealand, met its primary endpoint of safety, showing NTCELL implantation was well tolerated, with no adverse events considered to be related to NTCELL. NTCELL implantation also improved clinical features of Parkinson’s disease in the four patients studied, as measured by validated neurological rating scales and questionnaires, with the improvement sustained at 26 weeks post-implant.

LCT plans to initiate the confirmatory Phase IIb study in the fourth quarter of 2015. The study will be led by Dr. Snow at Auckland City Hospital. The efficacy and safety endpoints will be the same as those evaluated in the Phase I/IIa study.

Video/news released today
 

http://www.3news.co.nz/nznews/nz-pig...#axzz3d8Q1h5iX

hope it's more than placebo affect.

Didn't this used to be called Spheramine.

As such it failed.

Perhaps this is different.

Neil.

spheramine encased the implants in a gel to prevent rejection but other than that completely different. spheramine cells are dopamine producing cells from human cadaver eyeballs - epithelial(?) cells. dopamine is in the eye as a pigment by chance.

LCT cells are from pigs that were dropped off on a remote island years ago and are uniquely isolated from pig and other diseases.

No it is not the same.

https://www.michaeljfox.org/foundati...=76&category=3

kiwi33 this is in your neck of the woods?

My neck of the woods too:)

Very small trial totally NZ initiated and driven. Arose from NZ research. I imagine it will be 3 plus years before we really know how it's going. The positive is no rejection of the implant. Novel to use pig cells and the presence of cerebrospinal fluid is a first I think.

Kiwi waiting to hear your take on it (and I was amused by this mistake in the U.S. NIH specs - ability to fly to Vancouver for PET scan - 10 plus hours, really!)

oT - Kiwi and Dilmar
 

Do you know a fellow parky who posted on this site as rationalist and Howardh.

Real positive guy often wondered what happened to him.

Anyway back to the thread.

Neil.

Don't know him Neil. Have been looking but no luck yet.

they posted a little more info
 

http://www.lctglobal.com/upload/pres...er%20FINAL.pdf

they also had a conference call today, no replay# was given.

said next trial only open, as of now, to people living in southern island of N.Z., have to be close by for many followups. 3 of 4 patients stayed on same drug dosages, 1 patient reduced meds by 50%, longest patient was 76 weeks. all 4 patients were dbs candidates before operation, they can still choose DBS but all 4 declined, wanting to see how implants do. no date on when next trial will begin but presenter very positive.

they think it will work better on less advanced patients who have more viable neurons. imagine that!

the info for the cc doesn't give a replay phone#, the one on their p.r. won't work.

article Mayor's pigs help people with Parkinson's Disease
 

recording of conference call
 

[QUOTE= Kiwi waiting to hear your take on it (and I was amused by this mistake in the U.S. NIH specs - ability to fly to Vancouver for PET scan - 10 plus hours, really!)[/QUOTE].

Thank you for the audio link Soccertese. It is very informative.

Listening to the Audio I see there was no mistake in the spec, trial participants did fly to Vancouver for a scan! Most humble apologies for my mistake. I live in the area so now to see if I can get on that trial!