Clinical trials
 

For some reason the Netherlands is at the forefront of quite a bit of the research/clinical trials:

https://clinicaltrials.gov/ct2/resul...europathy&pg=1

Where do I sign up?
 

Some of the info is around the USA, I have already been on Metanx and am still on Foltanx. Will search another supplement mentioned. I would volunteer for a muscle strength study. Thanks, Ken in Texas.

Hi Ken,

Is there any reason why both Metanx and Foltanx are prescription only given they are supplements? Makes me wonder if it's mainly about money or is there really a difference in efficacy as opposed to over the counter supplements. I guess that's what they are trying to prove in the clinical study.

Cliffman :)

I am from the Netherlands and I didn't know that

It seems then that you're well situated to take advantage of some trials.

Metanx was too expensive for me
 

The only reason that they are RX'd IMO is that one is a mix of three or more and the Foltanx is simpler but still a mix. And yes, it's about money. I am thinking about trying the Agmatine Sulfate that bodybuilders use to supplement performance. Only powder so far, hoping to see a pill. Good Luck, Ken in Texas.

Be careful with clinical trials!...

This last week was a horrific event in France, doing a trial on a new cannabinoid drug.... brain death! (unexpected).
http://www.scientificamerican.com/ar...-proves-fatal/

I hope this isn't too far off the beaten path of the topic, but I wish they would study the whole better before isolating. This assumption they could isolate this process involving a cannabanoid receptor without a balance of other portions of the plant seems like bad science, though so does their dosing sequence.

What a shame for the participants. I hope that marijuana gets rescheduled so that it can be tested more thoroughly in the US. I get tired of trying to discuss it as an issue rationally with people only to have it devolve into some straw man festival.

Anyway, carry on.

Yeah, I heard about that. Was pretty surprised/shocked/taken aback. I haven't looked into what happened or they think happened. As I see it, most studies are putting you into guinea pig territory, so definitely do your research and know the risks. They can be dangerous.

It was a Phase I trial. These are first in man and are very dangerous in my opinion.

This has nothing to do with marijuana! We produce cannabinoids as neurotransmitter s in our brains, which are broken down by enzymes. The mystery drug was to inhibit this process.

Don't I feel silly.

I would like to thank David for the link, more for the information than anything, though if that Ottawa mindfulness trial were not ending I would be considering making that drive depending on how often.

It is nice to see both what has been done, thought about and in the pipeline.

My pleasure, of course. I thought we could carefully keep an eye on things and see what we can find. I didn't notice that study. Do you have a Zen temple close by? If so, you can just do some meditation there. I'm just beginning and the expert friend I have is helping me a long. So many of us have stress as a trigger, and when mine came on or broke on last year, I was at the height of my stress. How terrible! I should have started this before.

What happened in that study is still unknown. Here are two links:

http://www.hightimes.com/read/french...ES+Magazine%29

http://www.ibtimes.co.uk/france-drug...-death-1538644

It seems to be the case that the patients who suffered either had preexisting conditions or were given very high doses - they received the highest doses. So little seems to be known at this time. How cannabinoids work on the brain is a very complex process, and there are so many cannabinoids that we don't even understand and have not at all studied, pretty much anything other than THC and CBD. More funding and research is needed, since the therapeutic value is great. I'm quite curious what happened here, whether it was dosage, negligence and or something else.